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Synchronous cancer and advanced gastric stage (III-IV) were adverse independent prognostic factors, and second primary tumors were often diagnosed within 5 years.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/features-of-synchronous-and-metachronous-dual-primary-gastric-and-colorectal-cancer/386532/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/features-of-synchronous-and-metachronous-dual-primary-gastric-and-colorectal-cancer/386532.png","ImageObject",300,407,{"name":42,"@type":43},"Blitz","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-27","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",12,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the study aim for patients with dual primary gastric and colorectal cancer (DPGCC)?","Question",{"text":63,"@type":64},"To analyze clinicopathologic characteristics and prognosis of synchronous versus metachronous cancers in patients with DPGCC.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were survival outcomes compared between synchronous and metachronous groups?",{"text":68,"@type":64},"Overall survival was compared using Kaplan-Meier survival methods, with Cox proportional hazards models for univariate and multivariate identification of independent prognostic factors.",{"name":70,"@type":61,"acceptedAnswer":71},"What factors were associated with overall survival in the multivariate analysis?",{"text":72,"@type":64},"Synchronous cancer and stage III–IV gastric cancer were risk prognostic factors for OS, while gastrectomy was a protective prognostic factor.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},386532,1790386805,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146},24464137899374,"https://us-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","| W | J | G | O | World Journal of\u003Cbr>Gastrointestinal Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Oncol 2023 November 15; 15(11): 1864-1873  \nDOI: 10.4251/wjgo.v15.i11.1864 ISSN 1948-5204 (online)  \nORIGINAL ARTICLE  \nCase Control Study  \nFeatures of synchronous and metachronous dual primary gastric and colorectal cancer  \nYi-Jia Lin, Hua-Xian Chen, Feng-Xiang Zhang, Xian-Sheng Hu, Hai-Juan Huang, Jian-Hua Lu, Ye-Zi Cheng, Jun-Sheng Peng, Lei Lian  \nSpecialty type: Oncology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): 0  \nGrade B (Very good): B  \nGrade C (Good): C  \nGrade D (Fair): 0  \nGrade E (Poor): 0  \nP-Reviewer: Jeong KY, South Korea; Ogino S, United States  \nReceived: August 25, 2023  \nPeer-review started: August 25, 2023  \nFirst decision: September 5, 2023  \nRevised: September 15, 2023  \nAccepted: October 16, 2023  \nArticle in press: October 16, 2023  \nPublished online: November 15, 2023  \nYi-Jia Lin, Feng-Xiang Zhang, Xian-Sheng Hu, Ye-Zi Cheng, Jun-Sheng Peng, Lei Lian, Department of General Surgery (Gastrointestinal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, Guangdong Province, China  \nHua-Xian Chen, Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, Guangdong Province, China  \nHai-Juan Huang, Jian-Hua Lu, Follow-up office, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, Guangdong Province, China  \nCorresponding author: Lei Lian, MD, PhD, Surgeon, Surgical Oncologist, Department of General Surgery (Gastrointestinal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, No. 26 Yuancun Erheng Road, Guangzhou 510655, Guangdong Province, China.  \n[lianlei2@mail.sysu.edu.cn](lianlei2@mail.sysu.edu.cn)  \nAbstract  \nBACKGROUND  \nStudies evaluating the characteristics of dual primary gastric and colorectal cancer (CRC) (DPGCC) are limited.  \nAIM  \nTo analyze the clinicopathologic characteristics and prognosis of synchronous and metachronous cancers in patients with DPGCC.  \nMETHODS  \nFrom October 2010 to August 2021, patients with DPGCC were retrospectively reviewed. The patients with DPGCC were divided into two groups (synchronous and metachronous) . We compared the overall survival (OS) between the groups using Kaplan-Meier survival methods. Univariate and multivariate analyses were performed using Cox’s proportional hazards model to identify the independent prognostic factors for OS.  \nRESULTS  \nOf the 76 patients with DPGCC, 46 and 30 had synchronous and metachronous cancers, respectively. The proportion of unresectable CRC in patients with synchronous cancers was higher than that in patients with metachronous cancers (28.3% vs 3.3%, P = 0.015) . The majority of the second primary cancers had  \n WJGO  [https://www.wjgnet.com](https://www.wjgnet.com) 1864 November 15, 2023  Volume 15  Issue 11   \nLin YJ et al. Features of DPGCC  \noccurred within 5 years. Kaplan-Meier survival analysis showed that the patients with metachronous cancers had abetter prognosis than patients with synchronous cancers (P = 0.010) . The patients who had undergone gastrectomy (P \u003C 0.001) or CRC resection (P \u003C 0.001) had a better prognosis than those who had not. In the multivariate analysis, synchronous cancer [hazard ratio (HR) = 6.8, 95% confidence interval (95%CI): 2.0-22.7, P = 0.002)] and stage III-IV gastric cancer (GC) [HR = 10.0, 95%CI: 3.4-29.5, P \u003C 0.001)] were risk prognostic factor for OS, while patients who underwent gastrectomy was a protective prognostic factor for OS [HR = 0.2, 95%CI: 0.1-0.6, P = 0.002] .  \nCONCLUSION  \nRegular surveillance for metachronous cancer is necessary during postoperative follow-up. Surgical resection is the mai","cbCaimlCS4H8PUXA","https://ap.wps.com/l/cbCaimlCS4H8PUXA","pdf",837529,11,"English","# Abstract\n## Background\n## Aim\n## Methods\n## Results\n## Conclusion\n# Core Tip\n# Introduction\n# Citation","[{\"question\":\"What was the study aim for patients with dual primary gastric and colorectal cancer (DPGCC)?\",\"answer\":\"To analyze clinicopathologic characteristics and prognosis of synchronous versus metachronous cancers in patients with DPGCC.\"},{\"question\":\"How were survival outcomes compared between synchronous and metachronous groups?\",\"answer\":\"Overall survival was compared using Kaplan-Meier survival methods, with Cox proportional hazards models for univariate and multivariate identification of independent prognostic factors.\"},{\"question\":\"What factors were associated with overall survival in the multivariate analysis?\",\"answer\":\"Synchronous cancer and stage III–IV gastric cancer were risk prognostic factors for OS, while gastrectomy was a protective prognostic factor.\"}]","Features of synchronous and metachronous dual primary gastric and colorectal cancer | PDF",1790274149,28]