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Results indicate elevated UA increases risk for specific cancers, while mediation implicates fatty acid traits, especially the docosahexaenoic acid/trans fatty acid ratio, in lung cancer risk.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/fatty-acid-traits-mediate-the-effects-of-uric-acid-on-cancers-a-mendelian-randomization-study/331636/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/fatty-acid-traits-mediate-the-effects-of-uric-acid-on-cancers-a-mendelian-randomization-study/331636.png","ImageObject",300,407,{"name":42,"@type":43},"Genevieve","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",5,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why did the study focus on fatty acid traits in relation to uric acid and cancer?","Question",{"text":63,"@type":64},"Prior findings on UA and cancer risk were conflicting, and the mechanisms involving UA levels, fatty acid traits, and cancer outcomes were unclear. The study specifically tested whether fatty acid traits mediate the UA–cancer relationship.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were causal effects assessed among uric acid, fatty acid traits, and cancer risk?",{"text":68,"@type":64},"The study used Mendelian randomization with genetic data from large-scale genome-wide association studies. The main approach was inverse variance-weighted with Bayesian-weighted Mendelian randomization, complemented by other MR models and sensitivity analyses.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the mediation analysis show regarding lung cancer risk?",{"text":72,"@type":64},"Fatty acid traits mediated the relationship between UA levels and lung cancer risk. 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Genet. 15:1449205 .  \ndoi: 10.3389/fgene.2024.1449205  \nCOPYRIGHT  \n© 2024 Li, Zhang, Fu, Wang, Cai, Xu, Xing and Tong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nFatty acid traits mediate the effects of uric acid on cancers: a Mendelian randomization study  \nJianing Li 1, Yongsheng Zhang 2, Tong Fu 3, Songyan Wang 4, Hongbo Cai 4, Fenghua Xu 4, Guoli Xing 4 and Ying Tong 4*  \n1Heilongjiang University of Chinese Medicine, Harbin, China, 2Harbin Institute of Technology, Harbin, China, 3Brandeis University, Waltham, MA, United States, 4First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China  \nIntroduction: Previous findings on the association between uric acid (UA) levels and cancer risk are conflicting. Moreover, the mechanisms underlying the interactions between UA levels, fatty acid traits, and cancer outcomes remain complex; it is still unclear whether elevated UA levels influence fatty acid traits and, thereby, contribute to an increased cancer risk. Therefore, we aimed to investigate the association between UA levels and cancer risk, with a specific focus on the potential mediating role of fatty acid traits.  \nMethods: We employed a Mendelian randomization (MR) analysis utilizing genetic data from large-scale genome-wide association studies to assess the causal relationships among UA levels, fatty acid traits, and cancer risk. The primary method used was the inverse variance-weighted approach alongside Bayesianweighted Mendelian randomization. Other MR models were also applied for comparison. Sensitivity analyses, based on various statistical assumptions, were also performed to evaluate the robustness of the findings. A two-step MR analysis was conducted to explore the mediating effects of fatty acid traits on the relationship between UA levels and cancer risk.  \nResults and Discussion: Elevated UA levels were associated with an increased risk of in situ neoplasms, cervical cancer, and invasive mucinous ovarian cancer, while they were linked to a decreased risk of cancers of the eye and adnexa, small cell lung cancer, bronchus and lung cancer, respiratory system and intrathoracic organ cancers, as well as lung cancer. Mediation analysis revealed that fatty acid traits, particularly the docosahexaenoic acid/trans fatty acid ratio, mediated the relationship between UA levels and lung cancer risk. These findings underscore the potential of fatty acid traits to mediate the association between UA levels and cancer risk, offering new insights for targeted interventions and potentially improving clinical outcomes.  \nKEYWORDS  \nMendelian randomization, uric acid, fatty acids, cancer, mediate  \n1 Introduction  \nCancer remains a significant global health burden, with an estimated 19.3 million new cases and 10 million cancer-related deaths worldwide in 2020 (Danpanichkul et al., ","cbCairI06K9lMl5y","https://ap.wps.com/l/cbCairI06K9lMl5y","pdf",2432931,12,"English","# Introduction\n# Methods\n# Results and Discussion\n# Keywords","[{\"question\":\"Why did the study focus on fatty acid traits in relation to uric acid and cancer?\",\"answer\":\"Prior findings on UA and cancer risk were conflicting, and the mechanisms involving UA levels, fatty acid traits, and cancer outcomes were unclear. The study specifically tested whether fatty acid traits mediate the UA–cancer relationship.\"},{\"question\":\"How were causal effects assessed among uric acid, fatty acid traits, and cancer risk?\",\"answer\":\"The study used Mendelian randomization with genetic data from large-scale genome-wide association studies. The main approach was inverse variance-weighted with Bayesian-weighted Mendelian randomization, complemented by other MR models and sensitivity analyses.\"},{\"question\":\"What did the mediation analysis show regarding lung cancer risk?\",\"answer\":\"Fatty acid traits mediated the relationship between UA levels and lung cancer risk. The docosahexaenoic acid/trans fatty acid ratio was highlighted as a key mediator.\"}]","Fatty acid traits mediate the effects of uric acid on cancers - a Mendelian randomization study | PDF",1789994388]