[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-427282-105":3,"detail-sidebar-cat-0-en-105":85,"doc-detail-427282-en":134},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":78,"head_meta":80,"extra_data":82,"updated_unix":84},105,"en","fatigue-health-and-mortality-from-age-70-100","FATIGUE, HEALTH AND MORTALITY FROM AGE 70-100","","Fatigue is common with aging but has been poorly characterized. This study examined how fatigue relates to prevalence, health and functional status, and mortality from ages 70 to 100. Using the Jerusalem Longitudinal Study (1990–2021), a community cohort was followed across ages 70, 78, 85, 90, 95, and 100 with comprehensive fatigue assessment and mortality tracking. Regression and survival analyses showed fatigue had strong cross-sectional and longitudinal links to loneliness, self-rated health, ADL dependence, and physical activity, with reduced survival in several age intervals. After adjustment, fatigue at ages 70, 85, and 90 predicted higher mortality, while patterns with common medical morbidities were inconsistent.",{"@graph":14,"@context":77},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/fatigue-health-and-mortality-from-age-70-100/427282/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/fatigue-health-and-mortality-from-age-70-100/427282.png","ImageObject",300,407,{"name":42,"@type":43},"Eliana","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-08","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69,73],{"name":60,"@type":61,"acceptedAnswer":62},"How was fatigue measured in the study?","Question",{"text":63,"@type":64},"Fatigue was assessed using a direct question: “Do you feel generally tired?”","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What ages and participants were included?",{"text":68,"@type":64},"Participants from a community-dwelling cohort born in 1920–21 were followed at ages 70, 78, 85, 90, 95, and 100, with sample sizes reported for each age group.",{"name":70,"@type":61,"acceptedAnswer":71},"What health and functional outcomes were associated with fatigue?",{"text":72,"@type":64},"Fatigue was significantly associated with cross-sectional measures and later deterioration related to loneliness, self-rated health, ADL dependence, and physical activity.",{"name":74,"@type":61,"acceptedAnswer":75},"Did fatigue predict mortality after accounting for other risk factors?",{"text":76,"@type":64},"Yes. After adjusting for known mortality risk factors, fatigue at ages 70, 85, and 90 was associated with increased mortality, and fatigued participants showed decreased survival in multiple age intervals.","https://schema.org",{"og:url":32,"og:type":79,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":81,"canonical":32},"index,follow",{"doc_id":83,"site_id":7},427282,1791097470,{"code":4,"msg":86,"data":87},"success",[88,92,96,100,105,110,114,118,123,126,130],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Exam",70,"exam",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},5,"Comic",60,"comic",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},6,"Technology",50,"technology",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},"Research & Report",30,"research-report",{"id":119,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},9,"Religion & Spirituality",20,"religion-spirituality",{"id":121,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":121,"slug":125},"World Cup","world-cup",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":127,"slug":129},10,"Lifestyle","lifestyle",{"id":131,"doc_module":4,"doc_module_name":25,"category_name":132,"show_sort_weight":101,"slug":133},19,"General","general",{"code":4,"msg":86,"data":135},{"doc_id":83,"user_id":136,"nickname":42,"user_avatar":137,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":22,"language":143,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":12,"update_tm":147,"read_time":30},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","Innovation in Aging, 2025, Vol. 9, No. S2 49  \nAbstract citation ID: igaf122.163  \nFATIGUE, HEALTH AND MORTALITY FROM  \nAGE 70-100  \nIrit Stessman-Lande1, Aliza Rozenberg2, Jochanan Stessman3, and Jeremy Jacobs4, 1. Hadassah University Medical Centers; The Department of Geriatric Rehabilitation, Jerusalem, Yerushalayim, Israel, 2. Hebrew University of Jerusalem, Hadassah Medical Center, Jerusalem, Yerushalayim, Israel, 3. Hebrew University of Jerusalem, Hadassah Medical Center Faculty of Medicine, Jerusalem, Yerushalayim, Israel, 4. Hadassah Hebrew University Hospital, Jerusalem, Yerushalayim, Israel  \nFatigue is common with aging, yet poorly described. We examined the prevalence, health and functional status, and mortality associated with fatigue between ages 70-100. The Jerusalem Longitudinal Study (1990-2021) prospectively followed a community-dwelling cohort born 1920-21, at ages 70, 78, 85, 90, 95 and 100 (n = 604, 1024, 1222, 729, 508, 205 respectively) . Comprehensive assessment included fatigue (“Do you feel generally tired?”) and mortality data. Logistic regression models (adjusted for gender, education, self-rated health [SRH], Charlson comorbidity index [CCI], ADL, depression, chronic musculoskeletal pain), Kaplan-Meier survival curves, and Cox proportional hazards models (adjusted for gender, education, CCI) were performed. At ages 70, 78, 85, 90, 95, 100 the prevalence of fatigue was 29.4%, 52. 3%, 67.9%, 77.2%, 64.9%, and 65. 6% . Between age 70-100, fatigue was significantly associated with numerous cross-sectional health and functional measures, and subsequent deterioration for loneliness, SRH, ADL dependence, and physical activity. In contrast, no consistent pattern of association with current or subsequent common medical morbidities was observed. Significantly decreased survival rates were observed among fatigued vs. non-fatigued subjects at ages 70-78, 78-85, 85-90, 90-95: 69.6% vs 80.8%(p = 0.0078), 64.9% vs 73.3%(p = 0.0016), 60.6% vs 76.4%(p \u003C 0.0001), 51.3% vs 65.0%(p = 0.0068) respectively, yet not 95-100: 21.7% vs 18.8%(p = 0.99). After adjusting for known mortality risk factors, fatigue at age 70, 85 and 90 was associated with increased mortality. Fatigue is increasingly common with advancing age, and demonstrates significant negative impact upon health and survival. The poor association with medical morbidities raises questions concerning possible pathways of action.","cbCaipdv4t0oIxQG","https://ap.wps.com/l/cbCaipdv4t0oIxQG","pdf",107432,"English","# Abstract\n## Study Design and Measures\n## Statistical Analyses\n## Prevalence and Health Associations\n## Mortality Findings and Interpretation","[{\"question\":\"How was fatigue measured in the study?\",\"answer\":\"Fatigue was assessed using a direct question: “Do you feel generally tired?”\"},{\"question\":\"What ages and participants were included?\",\"answer\":\"Participants from a community-dwelling cohort born in 1920–21 were followed at ages 70, 78, 85, 90, 95, and 100, with sample sizes reported for each age group.\"},{\"question\":\"What health and functional outcomes were associated with fatigue?\",\"answer\":\"Fatigue was significantly associated with cross-sectional measures and later deterioration related to loneliness, self-rated health, ADL dependence, and physical activity.\"},{\"question\":\"Did fatigue predict mortality after accounting for other risk factors?\",\"answer\":\"Yes. After adjusting for known mortality risk factors, fatigue at ages 70, 85, and 90 was associated with increased mortality, and fatigued participants showed decreased survival in multiple age intervals.\"}]","FATIGUE, HEALTH AND MORTALITY FROM AGE 70-100 | PDF",1790643383]