[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-424992-105":59,"doc-detail-424992-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","fasting-mimicking-diet-cycles-regeneration-biological-age-and-disease","Fasting Mimicking Diet Cycles - Regeneration, Biological Age, and Disease","","Fasting mimicking diets (FMDs) are low-calorie, high-fat dietary interventions lasting 4–7 days, used periodically to enhance healthspan and reduce age-related disease incidence. Animal research shows FMD cycles trigger stem cell activation, cellular reprogramming, and autophagy, supporting longevity and regression of multiple diseases. Randomized clinical studies report reversal of insulin resistance, regression of pre-diabetes and diabetes, and lower diabetes and hypertension medication use via mechanisms not linked to weight loss.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/fasting-mimicking-diet-cycles-regeneration-biological-age-and-disease/424992/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/fasting-mimicking-diet-cycles-regeneration-biological-age-and-disease/424992.png","ImageObject",300,407,{"name":92,"@type":93},"acoobca","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are fasting mimicking diets (FMDs) and how long do they last?","Question",{"text":112,"@type":113},"FMDs are low-calorie, protein- and high-fat compositions lasting 4–7 days, used as periodic dietary interventions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What benefits do FMD cycles show in animal studies?",{"text":117,"@type":113},"FMD cycles promote stem cell activation, cellular reprogramming, and autophagy, leading to longevity extension and regression of multiple diseases and conditions.",{"name":119,"@type":110,"acceptedAnswer":120},"How do clinical studies describe the effects of FMD cycles on metabolic health?",{"text":121,"@type":113},"Randomized clinical studies indicate FMD cycles reverse insulin resistance, promote pre-diabetes and diabetes regression, and reduce diabetes and hypertension drug use through mechanisms not correlated with weight loss.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},424992,1791215766,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81,"preview_page_count":4},3985747870733,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","408 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.1389  \nFASTING MIMICKING DIET CYCLES, REGENERATION, BIOLOGICAL AGE, AND DISEASE  \nValter Longo, USC Leonard Davis School of Gerontology, Los Angeles, California, United States  \nFasting mimicking diets (FMDs) are low calorie and protein and high fat compositions lasting 4-7 days emerging as periodic dietary interventions with the potential to improve healthspan and decrease the incidence of age-related diseases. In animal studies, FMD cycles promote stem cell activation, cellular reprogramming and autophagy leading to longevity extension but also to the regression of multiple diseases and conditions. Recent randomized clinical studies consistently indicate that FMD cycles reverse insulin resistance and promote pre-diabetes and diabetes regression and result in lower diabetes and hypertension drug use by a mechanisms not correlated with weight loss. The latest studies indicate that FMD cycles can improve clinical response to autoimmune disease drugs and reverse chemosensory dysfunction raising the possibility that the multi-system regenerative effects demonstrated in mice and rats are conserved in humans, as also supported by a 2.5 years of biological age reduction associated with 3 FMD cycles in 2 different clinical trials.","cbCainlelIsiDyDJ","https://ap.wps.com/l/cbCainlelIsiDyDJ","pdf",398046,"English","# Background\n# Mechanisms and Preclinical Findings\n## Stem cell activation, reprogramming, and autophagy\n# Randomized Clinical Evidence\n## Insulin resistance and diabetes regression\n## Medication reduction independent of weight loss\n# Emerging Evidence in Autoimmune Disease and Sensory Dysfunction\n## Biological age changes across clinical trials","[{\"question\":\"What are fasting mimicking diets (FMDs) and how long do they last?\",\"answer\":\"FMDs are low-calorie, protein- and high-fat compositions lasting 4–7 days, used as periodic dietary interventions.\"},{\"question\":\"What benefits do FMD cycles show in animal studies?\",\"answer\":\"FMD cycles promote stem cell activation, cellular reprogramming, and autophagy, leading to longevity extension and regression of multiple diseases and conditions.\"},{\"question\":\"How do clinical studies describe the effects of FMD cycles on metabolic health?\",\"answer\":\"Randomized clinical studies indicate FMD cycles reverse insulin resistance, promote pre-diabetes and diabetes regression, and reduce diabetes and hypertension drug use through mechanisms not correlated with weight loss.\"}]","Fasting Mimicking Diet Cycles - Regeneration, Biological Age, and Disease | PDF",1790635924]