[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-385618-105":59,"doc-detail-385618-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","fasting-from-physiology-to-pathology","Fasting: From Physiology to Pathology","","Overnutrition drives numerous human diseases, including neurodegenerative disorders, metabolic dysfunction, and cancers, making dietary fasting an appealing intervention. This review consolidates recent animal and human evidence on how fasting influences physiology and pathology, emphasizing mechanisms that link energy scarcity to molecular timing, gut microbiome changes, and tissue homeostasis. Findings suggest fasting can slow aging across species and reduce disease risk while limiting side effects compared with chronic dietary restriction. It further highlights therapeutic promise and discusses combining pharmacologic approaches with fasting as a treatment regimen.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/fasting-from-physiology-to-pathology/385618/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/fasting-from-physiology-to-pathology/385618.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-25","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is fasting considered a promising strategy against overnutrition-related diseases?","Question",{"text":112,"@type":113},"Overnutrition increases the risk of multiple diseases, including neurodegenerative disorders, metabolic disorders, and cancers. The document describes fasting as a dietary intervention that counters overnutrition and can protect against these conditions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does calorie restriction relate to fasting in the document?",{"text":117,"@type":113},"The review states that calorie restriction (CR) and fasting have been extensively studied. Both interventions are reported to prolong lifespan and improve healthspan by delaying onset and slowing progression of various diseases.",{"name":119,"@type":110,"acceptedAnswer":120},"What mechanisms are discussed for how fasting influences physiology and disease?",{"text":121,"@type":113},"The document explains that CR/fasting effects involve nutrient-sensing pathways, particularly mTOR and AMPK. It links these pathways to regulation of autophagy, inflammation, and downstream processes such as ULK1 activity and lysosome-related gene expression.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},385618,1790539242,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","REVIEW  \n[www.advancedscience.com](www.advancedscience.com)  \nFasting: From Physiology to Pathology  \nDongmei Tang, Qiuyan Tang, Wei Huang, Yuwei Zhang, Yan Tian,* and Xianghui Fu*  \nOvernutrition is a risk factor for various human diseases, including neurodegenerative diseases, metabolic disorders, and cancers. Therefore, targeting overnutrition represents a simple but attractive strategy for the treatment of these increasing public health threats. Fasting as a dietary intervention for combating overnutrition has been extensively studied. Fasting has been practiced for millennia, but only recently have its roles in the molecular clock, gut microbiome, and tissue homeostasis and function emerged. Fasting can slow aging in most species and protect against various human diseases, including neurodegenerative diseases, metabolic disorders, and cancers. These centuried and unfading adventures and explorations suggest that fasting has the potential to delay aging and help prevent and treat diseases while minimizing side effects caused by chronic dietary interventions. In this review, recent animal and human studies concerning the role and underlying mechanism of fasting in physiology and pathology are summarized, the therapeutic potential of fasting is highlighted, and the combination of pharmacological intervention and fasting is discussed as anew treatment regimen for human diseases.  \nstrategies, namely, calorie restriction (CR) and fasting, have been extensively studied. Accumulating evidence has documented the beneficial effects of both types of interventions on prolonging lifespan and improving healthspan by delaying the onset and slowing the progression of various diseases. [1–5]  \nThe CR dietary regimen limits the total calorie intake to ≈15–40% relative to ad libitum without malnutrition.[1] The effectsof CR on delaying aging and increasing healthspan have been studied in a broad spectrum of animals, from monocellular eukaryotes to nonhuman primates. [3,6,7] Importantly, increasing evidence from human studies recapitulates numerous key findings from animal experiments. [8–11] For example, it has been shown that 2-year CR for nonobese individuals has the ability to decrease systemic oxidative damage and promote healthspan. [8,12] In addition, CR has profound effects on a series of  \n1. Introduction  \nOvernutrition has been recognized as one of the major risk factors for a broad range of human diseases, especially obesityrelated disorders, such as neurodegenerative diseases, metabolic disorders, and cancers. In recent decades, tremendous effortshave been devoted to developing feasible strategies for counteracting overnutrition. To date, two major categories of dietary  \ndiseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), cancer, obesity, and diabetes, as well as many other metabolic disorders, as demonstrated by numerous basic and translational research. [13–20]  \nMechanistically, the overall effectiveness of CR seems tobe modulated by several factors, including autophagy and inflammation. Autophagy is regulated by nutrient-sensing signaling pathways,[21] particularly the mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK)  \nD. Tang  \nDivision of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital  \nSichuan University and Collaborative Innovation Center of Biotherapy Chengdu, Sichuan 610041, China  \nQ. Tang  \nNeurology Department of Integrated Traditional Chinese and Western Medicine, School of Clinical Medicine  \nChengdu University of Traditional Chinese Medicine Chengdu, Sichuan 610075, China  \nThe ORCID identification number(s) for the author(s) of this article  \ncan be found under [https://doi.org/10.1002/advs.202204487](https://doi.org/10.1002/advs.202204487)[ ](https://doi.org/10.1002/advs.202204487)© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH. This is an open ","cbCaibFQPvfbuRLB","https://ap.wps.com/l/cbCaibFQPvfbuRLB","pdf",5196487,27,"English","# Introduction\n# Calorie restriction and fasting as interventions\n## Effects on aging and healthspan\n# Mechanisms linking nutrient sensing to disease\n## Autophagy and inflammation\n# Therapeutic potential and combination strategies","[{\"question\":\"Why is fasting considered a promising strategy against overnutrition-related diseases?\",\"answer\":\"Overnutrition increases the risk of multiple diseases, including neurodegenerative disorders, metabolic disorders, and cancers. The document describes fasting as a dietary intervention that counters overnutrition and can protect against these conditions.\"},{\"question\":\"How does calorie restriction relate to fasting in the document?\",\"answer\":\"The review states that calorie restriction (CR) and fasting have been extensively studied. Both interventions are reported to prolong lifespan and improve healthspan by delaying onset and slowing progression of various diseases.\"},{\"question\":\"What mechanisms are discussed for how fasting influences physiology and disease?\",\"answer\":\"The document explains that CR/fasting effects involve nutrient-sensing pathways, particularly mTOR and AMPK. It links these pathways to regulation of autophagy, inflammation, and downstream processes such as ULK1 activity and lysosome-related gene expression.\"}]","Fasting: From Physiology to Pathology | PDF",1790270260,68]