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Findings showed overall QOL related positively to cognitive function, social support, and self-esteem, while memory complaints, seizure duration, seizure frequency, anxiety, and depression were negative 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\nFactors influencing quality of life in patients with temporal lobe epilepsy  \nAmina Tani 1 Nawal Adali2,3  \n1 Ibn Zohr University, National School of Applied Sciences, Health Sciences Department, Agadir, Morocco.  \n2 Ibn Zohr University, Faculty of Medicine and Pharmacy, REGNE Research Laboratory, Agadir, Morocco.  \n3 University Hospital of Agadir, Department of Neurology, Morocco.  \nArq. Neuro-Psiquiatr. 2025;83(1):s00451802552 .  \nAddress for correspondence Amina Tani (email: [aminatani33@gmail.com](aminatani33@gmail.com))  \nAbstract  \nKeywords  \n► Epilepsy, Temporal Lobe  \n► Quality of Life  \n► Cognition  \n► Depression  \n► Anxiety  \nBackground Temporal lobe epilepsy (TLE) predisposes individuals to cognitive difficulties and psychosocial consequences. Evaluating its impact on quality of life (QOL) is essential for patient care.  \nObjective To identify factors influencing QOL in low-income patients with TLE. Methods An institution-based cross-sectional study was conducted on 40 patients with TLE during neurological consultations at a day clinic in Agadir, Morocco. The Quality of Life in Epilepsy Inventory-31 (QOLIE-31) was used to measure QOL. Multivariate linear regression analysis was performed to assess the associations between QOL and demographic, clinical, psychiatric, social, and cognitive variables. Results were considered statistically significant at a p-value \u003C 0.05.  \nResults The mean overall QOL score was 48.14 􀀃 22.02. Among the seven scales of the QOLIE-31, the Seizure Worry scale had the lowest mean score. Cognitive function, social support, and self-esteem were positively associated with QOL. In contrast, memory complaints, seizure duration, seizure frequency, anxiety, and depression were negatively associated with QOL.  \nConclusion While current interventions primarily target seizure control, our findings emphasize the need for holistic approaches that address both cognitive and psychosocial challenges to optimize QOL.  \nINTRODUCTION  \nEpilepsy is a major neurological disorder affecting 􀀁 0. 5 to 1% of the world’s population.1 Its complex implications across physical, mental, and social domains2 contribute to a signifi cant public health burden. This burden is particularly acute in developing countries, which are home to over 80% of the global cohort of people with epilepsy.3 These regions are experiencing increased epilepsy-related mortality, often due to untreated manifestations, compounded by stigma and gaps in diagnostic and therapeutic infrastructure.4  \nreceived  \nDecember 31, 2023 received in its final form  \nAugust 8, 2024  \naccepted  \nSeptember 29, 2024  \nDOI [https://doi.org/](https://doi.org/)[ ](https://doi.org/)10.1055/s-0045-1802552 . ISSN 0004-282X.  \nThis concern is heightened in the context of temporal lobe epilepsy (TLE), a subset often resistant to antiseizure medications (ASMs), with hippocampal sclerosis being the most common cause. 5,6 Despite the efficacy of surgical interventions in reducing seizures, their adoption remains limited in resource-poor countries. Patients with TLE, particularly when untreated, suffer from cognitive impairment, anxiety, depression, low self-esteem, and social barriers.7,8  \nQuality of life (QoL) is a key measure to understand the experiences of patients with epilepsy (PWEs) living in developing countries.9 The literature 10–13 indicates that QoL  \n© 2025 . The Author(s) .  \nThis is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)).  \nThieme Revinter Publicações Ltda. , Rua Rego Freitas, 175, loja 1, República, São Paulo, SP, CEP 01220-010, Brazil  \n2 Quality of life in patients with temporal lobe epilepsy Tani and Adali  \nin epilepsy patients is influe","cbCaiiAFnqcikZQL","https://ap.wps.com/l/cbCaiiAFnqcikZQL","pdf",2505583,"English","# Abstract\n# Background\n# Objective\n# Methods\n# Results\n# Conclusion\n# Introduction\n# Methods\n## Study design and participants","[{\"question\":\"What is the objective of the study on quality of life in temporal lobe epilepsy?\",\"answer\":\"The study aims to identify factors influencing QOL in low-income patients with temporal lobe epilepsy (TLE).\"},{\"question\":\"How was quality of life measured in the study?\",\"answer\":\"Quality of life was measured using the Quality of Life in Epilepsy Inventory-31 (QOLIE-31).\"},{\"question\":\"Which factors were found to be positively and negatively associated with QOL?\",\"answer\":\"Cognitive function, social support, and self-esteem were positively associated with QOL, whereas memory complaints, seizure duration, seizure frequency, anxiety, and depression were negatively associated.\"}]","Factors influencing quality of life in patients with temporal lobe epilepsy | PDF",1790675597,25]