[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-437014-105":59,"doc-detail-437014-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","factitious-cheilitis-report-of-two-cases","Factitious Cheilitis: Report of Two Cases","","Factitious cheilitis (FC) is a rare psychodermatologic condition involving self-inflicted trauma to the lips and is frequently underdiagnosed or misidentified as infectious or neoplastic disease. Two young adult female patients presented with painful verrucous lip lesions; initial suspicion included squamous cell carcinoma and pustular cheilitis. Histopathology was nonspecific, but clinical patterns indicated self-inflicted injury. Both were diagnosed with FC and managed with topical therapy and referral for psychological support.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/factitious-cheilitis-report-of-two-cases/437014/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/factitious-cheilitis-report-of-two-cases/437014.png","ImageObject",300,407,{"name":92,"@type":93},"Cart","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is factitious cheilitis and why is it often missed?","Question",{"text":112,"@type":113},"Factitious cheilitis is a rare psychodermatologic condition caused by repetitive self-inflicted trauma to the lips. It is frequently underdiagnosed and commonly mistaken for infectious or neoplastic processes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What were the initial diagnostic suspicions in the two reported cases?",{"text":117,"@type":113},"The initial clinical suspicion in both cases included squamous cell carcinoma and pustular cheilitis, reflecting the verrucous and painful appearance of the lesions.",{"name":119,"@type":110,"acceptedAnswer":120},"How were the cases ultimately diagnosed and treated?",{"text":121,"@type":113},"Nonspecific histopathology and clinical history showing self-inflicted trauma supported the diagnosis of factitious cheilitis. Management included topical treatment and referral for psychological support, with psychotherapy and psychopharmacological care initiated in at least one case.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},437014,1791082655,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},18829141979164,"https://eur-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Clinical Case Reports  \nCASE SERIES  OPEN ACCESS   \nFactitious Cheilitis: Report of Two Cases  \nDaniel Mauricio Cuestas Rodriguez1  | Tatiana Carolina Reyes Vivas2  | Luis Daniel Pérez Cáceres3  | Laura Sofía Martínez Martínez4  | Nahomy Giraldo Mejía5,6  | Valentina Alvarez Mengual4   \n1Universidad el Bosque, Simón Bolívar Hospital, Bogotá, D.C. , Colombia | 2Centros Médicos Colsanitas, Bogotá, D.C. , Colombia | 3Fundación Universitaria Sanitas, Bogotá, D.C. , Colombia | 4Fundación Universitaria de Ciencias de la Salud, Hospital de San José, Bogotá, D.C. , Colombia | 5Universidad Antonio  \nNariño, Bogotá, D.C. , Colombia | 6Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia Correspondence: Laura Sofía Martínez Martínez ([lsmartinez1@fucsalud.edu.co](lsmartinez1@fucsalud.edu.co))  \nReceived: 12 July 2025 | Revised: 29 November 2025 | Accepted: 19 December 2025  \nCases originated from the following institutions: Centro Dermatológico Estudio Derma—Hospital Universitario de La Samaritana.  \nKeywords: differential diagnosis | factitious cheilitis | lip lesions | psychiatric comorbidity | psychodermatology | self-inflicted dermatoses  \nABSTRACT  \nFactitious cheilitis (FC) is a rare psychodermatologic condition characterized by self-inflicted trauma to the lips. It is frequently underdiagnosed and often mistaken for infectious or neoplastic processes. We report two cases of young adult female patients with painful verrucous lip lesions. In both cases, initial clinical suspicion included squamous cell carcinoma and pustular cheilitis. Histopathologic findings were nonspecific. Clinical history and behavior patterns revealed self-inflicted trauma. Both patients were ultimately diagnosed with FC and managed with topical treatment and referral for psychological support. These cases highlight the diagnostic challenges of FC and the importance of recognizing self-inflicted dermatoses in dermatologic practice. Failure to do so can lead to unnecessary procedures and treatments. FC should be considered in patients with chronic cheilitis and atypical lip lesions, especially in those with psychiatric comorbidities. A multidisciplinary approach is essential for proper diagnosis and management.  \n1 | Introduction  \nFactitious cheilitis (FC) is an artifact-related dermatosis characterized by white-grayish plaques on the vermilion border of the lips, caused by repetitive self-inflicted trauma. This condition is rare and frequently underdiagnosed, predominantly affecting women and young adults, many of whom have underlying psychiatric histories. Due to its prominent clinical features, diagnosis is often delayed, resulting in repeated biopsies with nonspecific findings and the administration of empirical treatments and unnecessary investigations—leading to significant healthcare costs. We present two cases of young adult women who were admitted to the dermatology department for verrucous lesions involving both lips.  \n2 | Case 1  \n2.1 | Clinical History/Examination  \nA 31-year-old female patient with a history of extensive longitudinal myelopathy presented with spastic paraparesis and neurological sequelae affecting the gastrointestinal and genitourinary systems.  \nShe was referred to the dermatology department with a 1-year history of progressively worsening verrucous lesions affecting both the upper and lower lips. The lesions were painful, rapidly growing, and recurrent, with no identifiable trigger despite prior surgical excision. The patient reported significant  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2026 The Author(s). Clinical Case Reports published by John Wiley & Sons Ltd.  \nClinical Case Reports, 2026; 14:e71792 1 of 6  \n[https://doi.org/10.1002/ccr3.71792](https://doi.org/10.1002/ccr3.71792)  \nKey Clinical Message  \nFactitious cheilitis should be considered as a di","cbCaiuepzbRDWvEo","https://ap.wps.com/l/cbCaiuepzbRDWvEo","pdf",1303820,"English","# Abstract\n# Introduction\n# Case 1\n## Clinical History/Examination\n## Differential Diagnosis, Investigations, and Treatment","[{\"question\":\"What is factitious cheilitis and why is it often missed?\",\"answer\":\"Factitious cheilitis is a rare psychodermatologic condition caused by repetitive self-inflicted trauma to the lips. It is frequently underdiagnosed and commonly mistaken for infectious or neoplastic processes.\"},{\"question\":\"What were the initial diagnostic suspicions in the two reported cases?\",\"answer\":\"The initial clinical suspicion in both cases included squamous cell carcinoma and pustular cheilitis, reflecting the verrucous and painful appearance of the lesions.\"},{\"question\":\"How were the cases ultimately diagnosed and treated?\",\"answer\":\"Nonspecific histopathology and clinical history showing self-inflicted trauma supported the diagnosis of factitious cheilitis. Management included topical treatment and referral for psychological support, with psychotherapy and psychopharmacological care initiated in at least one case.\"}]","Factitious Cheilitis: Report of Two Cases | PDF",1790679850,15]