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Mesoporous silica nanoparticles (MS50 and MS100) were fabricated and functionalized with polydopamine, cercosporin, and an arginine-glycine-aspartic acid peptide to enable integrin αvβ3-directed photodynamic therapy and photothermal therapy. MS@PD-RP-CE showed selective drug release, higher photothermal conversion efficiency, and reactive oxygen species generation under laser irradiation. MS100@PD-RP-CE improved cellular uptake and in vitro cytotoxicity against PANC-1 while sparing normal cells, supported by cell death mechanism assays and hemolytic biocompatibility results.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/fabrication-of-cercosporin-loaded-polydopamine-cloaked-mesoporous-silica-nanoparticles-enhanced-photothermalphotodynamic-and-anticancer-activity-in-pancreatic-cancer/352673/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/fabrication-of-cercosporin-loaded-polydopamine-cloaked-mesoporous-silica-nanoparticles-enhanced-photothermalphotodynamic-and-anticancer-activity-in-pancreatic-cancer/352673.png","ImageObject",300,407,{"name":92,"@type":93},"WPS_1786070896","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What key problems does the study address in pancreatic cancer therapy?","Question",{"text":112,"@type":113},"The study targets two challenges: poor tumor targeting and the limitations of relying on a single therapeutic approach for pancreatic cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were the nanoparticles designed for combined therapy?",{"text":117,"@type":113},"Mesoporous silica nanoparticles were functionalized with polydopamine, cercosporin, and an arginine-glycine-aspartic acid peptide to support photodynamic and photothermal effects aimed at integrin αvβ3.",{"name":119,"@type":110,"acceptedAnswer":120},"What differences were observed between MS100 and MS50 formulations?",{"text":121,"@type":113},"MS100@PD-RP-CE showed enhanced cellular uptake and greater cytotoxicity against PANC-1 cells in vitro, while selectively targeting cancer cells over normal cells compared with MS50@PD-RP-CE.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},352673,1790145847,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36},549768072016,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Journal of Materials Science: Materials in Medicine (2026)37:54  \n[https://doi.org/10.1007/s10856-026-07007-4](https://doi.org/10.1007/s10856-026-07007-4)  \nDELIVERY SYSTEMS  \nOriginal Research  \nFabrication of cercosporin-loaded polydopamine- cloaked mesoporous silica nanoparticles enhanced photothermalphotodynamic and anticancer activity in pancreatic cancer  \nJingsheng Hua1,2 ● Bo Ning3 ● Hongxin Zhang4  \nReceived: 16 October 2025 / Accepted: 14 January 2026 © The Author(s) 2026  \nAbstract  \nThe lack of tumor targeting ability and the failure of single therapeutic approaches are two challenges in the treatment of pancreatic cancer. Mesoporous silica (MS) nanoparticles of two sizes (MS50 and MS100) were fabricated and functionalized with polydopamine (PD), cercosporin (CE), and arginine-glycine-aspartic acid peptide (RP) for the dual purposes of photodynamic therapy (PDT) and photothermal therapy (PTT) aimed at integrin αvβ3 in pancreatic cancer. MS@PD-RP-CE were examined using several approaches, exhibiting selective drug release, enhanced photothermal conversion efficiency, and reactive oxygen species (ROS) generation under laser irradiation. MS100@PD-RP-CE exhibited enhanced cellular uptake and cytotoxicity against pancreatic cancer (PANC-1) in vitro, while selectively targeting pancreatic cancer cells over normal cells, in comparison to MS50@PD-RP-CE. The mechanism of cell death was analyzed utilizing Calcein-AM/PI, and nuclear staining techniques. MS100@PD-RP-CE demonstrated considerable biocompatibility, as shown by the hemolytic assay. Thus, MS100@PD-RP-CE demonstrates significant promise for the prospective treatment of pancreatic cancer.  \nGraphical Abstract  \n1 Introduction  \n* Hongxin Zhang [hongxinnano@outlook.com](hongxinnano@outlook.com)  \n1 Department of Hematology, Taizhou University Affiliated Municipal Hospital, School of Medicine, Taizhou University, Taizhou, China  \n2 Taizhou Key Laboratory of Tumor Molecular Markers and Targeted Therapy, Taizhou, China  \n3 Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China  \n4 Ward 1 of Department of Oncology, Shijiazhuang People’s Hospital, Shijiazhuang, China  \nPancreatic cancer is the most fatal of prevalent tumors, exhibiting a grim 5-year overall survival rate of under 9%  \n[1] . Despite significant advancements in cancer treatment, pancreatic cancer remains underperforming, with surgical excision as the sole potentially curative intervention [2] . In the realm of non-resectable pancreatic cancer, the primary first-line treatment modalities consist of systemic gemcitabine in conjunction with nab-paclitaxel, and the combination therapy of fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFIRINOX), alongside nab-paclitaxel (also  \nreferred to as Abraxane) in conjunction with gemcitabine [3, 4] . Nonetheless, these treatments encounter obstacles owing to dose-limiting toxicities, resulting in therapy discontinuation in a significant percentage of patients, between 60% and 70% . Significant side effects include nausea, tiredness, diarrhea, neutropenia, and neuropathy [2, 5, 6] .  \nImprovements in current science and technology have endowed nanoparticles with numerous beneficial properties, such as a substantial specific surface area, customizable pore size, elevated drug loading capacity, superior biocompatibility, and efficient targeted delivery to tumor tissues [7] . The simultaneous delivery of gemcitabine and cisplatin using nanoparticles may produce a synergistic impact on pancreatic cancer. The pancreatic cancer matrix consists of the extracellular matrix, vascular system, and tumor-associated fibroblasts, which can aggregate into a dense tumor mesenchyme that obstructs drug delivery [8] . Nano-drug delivery systems (NDDSs) possess the capability to surmount the tumor interstitial barrier for precise drug administration. Nanocarriers have emerged as a viable alternative to reduce the systemic toxicity of che","cbCaip59IZkSfKjv","https://ap.wps.com/l/cbCaip59IZkSfKjv","pdf",3841375,16,"English","# Abstract\n# Graphical Abstract\n# Introduction\n## Clinical challenges and current therapies\n## Nanoparticle-based delivery and mesoporous silica advantages\n## Rationale for combining PTT and PDT\n## Polydopamine as a multifunctional platform","[{\"question\":\"What key problems does the study address in pancreatic cancer therapy?\",\"answer\":\"The study targets two challenges: poor tumor targeting and the limitations of relying on a single therapeutic approach for pancreatic cancer.\"},{\"question\":\"How were the nanoparticles designed for combined therapy?\",\"answer\":\"Mesoporous silica nanoparticles were functionalized with polydopamine, cercosporin, and an arginine-glycine-aspartic acid peptide to support photodynamic and photothermal effects aimed at integrin αvβ3.\"},{\"question\":\"What differences were observed between MS100 and MS50 formulations?\",\"answer\":\"MS100@PD-RP-CE showed enhanced cellular uptake and greater cytotoxicity against PANC-1 cells in vitro, while selectively targeting cancer cells over normal cells compared with MS50@PD-RP-CE.\"}]","Fabrication of cercosporin-loaded polydopamine - cloaked mesoporous silica nanoparticles enhanced photothermalphotodynamic and anticancer activity in pancreatic cancer | PDF",1790100774]