[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-385128-105":59,"doc-detail-385128-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","extremely-elevated-prostate-specific-antigen-in-acute-prostatitis-a-case-report","Extremely Elevated Prostate-Specific Antigen in Acute Prostatitis - A Case Report","","Elevated prostate-specific antigen (PSA) usually suggests prostate cancer, yet non-malignant prostatic disorders can also raise PSA. This case report documents an atypical and rare presentation: a patient with acute prostatitis reaching an extreme PSA level of 1,398 ng/mL. The report reviews the unusual coexistence of markedly high PSA in acute prostatitis, within the background of benign prostatic hyperplasia (BPH) and chronic prostatitis, confirmed by biopsy.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/extremely-elevated-prostate-specific-antigen-in-acute-prostatitis-a-case-report/385128/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/extremely-elevated-prostate-specific-antigen-in-acute-prostatitis-a-case-report/385128.png","ImageObject",300,407,{"name":92,"@type":93},"Adam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",18,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why was the extremely high PSA level concerning in this patient?","Question",{"text":113,"@type":114},"Elevated PSA levels are commonly associated with prostate cancer, and extremely high PSA is usually suggestive of malignancy even though non-cancerous conditions can also elevate PSA.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What did the prostate biopsy show despite the very high PSA?",{"text":118,"@type":114},"The biopsy revealed benign prostatic tissue with acute and chronic inflammation and focal necrosis, with no malignant cells identified.",{"name":120,"@type":111,"acceptedAnswer":121},"How was the patient evaluated for metastatic disease?",{"text":122,"@type":114},"A whole-body bone scan using Tc-99m-MDP was negative for metastatic bone lesions.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},385128,1790813018,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":52},1374404737137,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Open Access Case  \nReport DOI: 10.7759/cureus.43730  \nReview began 08/08/2023  \nReview ended 08/16/2023  \nPublished 08/18/2023  \n© Copyright 2023  \nNepal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nExtremely Elevated Prostate-Specific Antigen in Acute Prostatitis: A Case Report  \nAnamika Nepal 1 , Prabhat Sharma 2 , Shristi Bhattarai 3 , Zubin Mahajan 4 , Akhya Sharma 5, 6, 4 , Ashok Sapkota 4 , Aviskar Sharma 4  \n1. Internal Medicine, Shankarapur Hospital, Kathmandu, NPL 2. Internal Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA 3. Internal Medicine, MacNeal Hospital, Chicago, USA 4. Internal Medicine, MacNeal Hospital, Berwyn, USA 5. Neurosciences, Tata Main Hospital, Jamshedpur, IND 6. Medicine, Kasturba Medical College, Manipal, IND  \nCorresponding author: Prabhat Sharma, [ps.nepal946@gmail.com](ps.nepal946@gmail.com)  \nAbstract  \nElevated prostate-specific antigen (PSA) levels are mostly suggestive of prostate cancer, but they are elevated in non-cancerous prostatic conditions as well. However, extreme levels of PSA as reported here have not been observed in cases other than prostatic cancer so far. Our patient had a significantly elevated PSA of 1,398 ng/mL in acute prostatitis. The purpose of this case report is to review the patient 's atypical and rare presentation of extremely high PSA in acute prostatitis in the background of benign prostatic hyperplasia (BPH) and chronic prostatitis.  \nCategories: Family/General Practice, Internal Medicine, Urology  \nKeywords: urinary tract infection (uti), prostate cancer (pca), prostate-specific antigen (psa), acute prostatitis, chronic prostatitis  \nIntroduction  \nElevated prostate-specific antigen (PSA) levels are concerning for underlying prostate cancer, although there are non-cancerous prostatic conditions that can result in elevated PSA levels. Urinary tract infection (UTI), benign prostatic hyperplasia (BPH), and prostatitis are some conditions that result in elevated PSA  \nlevels [1] . No correlation of low PSA levels to prostatic cancer has been established, but extremely high levels of PSA are almost always suggestive of prostate cancer [2] . Here, we present a case of an elderly patient with a severely enlarged prostate and extremely elevated PSA, whose prostatic biopsy revealed acute and chronic inflammation of the prostate and did not reveal prostatic cancer.  \nCase Presentation  \nAn 81-year-old male was admitted to our hospital with worsening mental status. He was a nursing home resident with multiple comorbidities including Alzheimer’s dementia, congestive heart failure, hypertension, BPH, and a recurrent history of UTIs. On examination, he was tachycardic, hypotensive, and hypoxic. He had a tense lower abdomen concerning bladder distension. The digital rectal exam revealed an enlarged and boggy prostate. His bladder scan revealed 700 mL of urine, drained by a urinary catheter. His labs were significant for leukocytosis, acute kidney injury, and pyuria. He was admitted with a diagnosis of acute septic encephalopathy secondary to UTI and acute hypoxic respiratory failure secondary to community-acquired pneumonia. His urine culture grew Escherichia coli which was resistant to fluoroquinolones and trimethoprim-sulphamethoxazole. He was treated in the intensive care unit, initially with a broad-spectrum antibiotic (meropenem), which was later deescalated to ampicillin based on culture and sensitivity results, oxygen supplementation, and non-invasive ventilation.  \nComputed tomography (CT) scan of the abdomen and pelvis without contrast, which was done as a part of the workup revealed a severely enlarged prostate (Figures 1, 2) . The prostatic size was radiologically calculated as 275 cc. His total PSA levels were elevated to 1,398 ng/m","cbCaic6g9hFlP2lu","https://ap.wps.com/l/cbCaic6g9hFlP2lu","pdf",438331,"English","# Abstract\n# Introduction\n# Case Presentation\n# How to cite this article\n# Discussion","[{\"question\":\"Why was the extremely high PSA level concerning in this patient?\",\"answer\":\"Elevated PSA levels are commonly associated with prostate cancer, and extremely high PSA is usually suggestive of malignancy even though non-cancerous conditions can also elevate PSA.\"},{\"question\":\"What did the prostate biopsy show despite the very high PSA?\",\"answer\":\"The biopsy revealed benign prostatic tissue with acute and chronic inflammation and focal necrosis, with no malignant cells identified.\"},{\"question\":\"How was the patient evaluated for metastatic disease?\",\"answer\":\"A whole-body bone scan using Tc-99m-MDP was negative for metastatic bone lesions.\"}]","Extremely Elevated Prostate-Specific Antigen in Acute Prostatitis - A Case Report | PDF",1790266851]