[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-458341-105":3,"detail-sidebar-cat-0-en-105":80,"doc-detail-458341-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","external-validation-of-joint-propagation-model-based-tau-pet-centaur-units-poster-presentation","External Validation of Joint Propagation Model-Based Tau PET CenTauR units - Poster Presentation","","Background: The Joint Propagation Model (JPM)-based CenTauR scale was introduced to harmonize tau-PET quantification across different radiotracers. Objective: This poster describes external validation of the CenTauR units, evaluating consistency and robustness of the scale when applied beyond the original development setting. Methods and Results: The work reports biomarker and neuroimaging related findings, presenting how CenTauR units perform across participating sites and datasets. Conclusions: The validation supports use of CenTauR units for standardized tau-PET quantification in multicenter research.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/external-validation-of-joint-propagation-model-based-tau-pet-centaur-units-poster-presentation/458341/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/external-validation-of-joint-propagation-model-based-tau-pet-centaur-units-poster-presentation/458341.png","ImageObject",300,407,{"name":42,"@type":43},"Riley West","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-07","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":33},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What is the purpose of the CenTauR scale in tau-PET imaging?","Question",{"text":62,"@type":63},"The CenTauR scale is designed to harmonize tau-PET quantification across different radiotracers. This helps make measurements more comparable.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"What does this poster focus on?",{"text":67,"@type":63},"It focuses on external validation of the JPM-based CenTauR units. The goal is to test performance beyond the original development setting.",{"name":69,"@type":60,"acceptedAnswer":70},"How is the validation intended to support research use?",{"text":71,"@type":63},"By evaluating consistency and robustness across sites and datasets, the poster aims to support standardized tau-PET quantification for multicenter studies.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},458341,1790752632,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":33,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":101,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":79,"read_time":143,"preview_page_count":4},1099523885074,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","DOI: 10. 1002/alz70856_106362  \nBIOMARKERS  \nPOSTER PRESENTATION  \nNEUROIMAGING  \nExternal Validation of Joint Propagation Model-Based Tau PET CenTauR units  \nAlexis Moscoso1, 2 Antoine Leuzy3 Lars Lau Raket4 Victor L. Villemagne5 Gregory Klein6 Matteo Tonietto7 Emily Olafson8 Suzanne L. Baker9 Ziad S. Saad 10 Santiago Bullich 11 Brian J Lopresti 12 Sandra Sanabria 13 Olivia Lutz 14, 15 Mercè Boada 16 Tobey J. Betthauser 17 Arnaud Charil 18 Emily C. Collins4 Jessica Collins 19 Roger N Gunn20 Makoto Higuchi21 Eric D. Hostetler22 R. Matthew Hutchison 19 Leonardo Iaccarino4  \nPhilip S. Insel23 Michael C. Irizarry24 Clifford R. Jack Jr.25 William J. Jagust26 Keith A. Johnson27 Sterling C Johnson28 Yashmin Karten3 Marta Marquié29 Sulantha Mathotaarachchi30 Mark A. Mintun4 Rik Ossenkoppele31, 32 Qi Huang33 Xiaxie Mao34 Johannes Gnörich35 Ioannis Pappas36  \nRonald Petersen25 Pedro Rosa-Neto39 Andrew W. Stephens 11 Michael Pontecorvo4 Hartmuth C. Kolb30  \nKonstantinos Chiotis37 Gil D. Rabinovici38 Christopher G Schwarz40 Ruben Smith41  \nAlex Whittington42 Maria C. Carrillo43 Samantha Budd Haeberlein44 Billy Dunn45  \nDiane Stephenson3 Nadine Tatton3 Matthias  \nBrendel46  \nFang Xie47 Christopher C. Rowe48 Oskar Hansson49 Vincent Dore50  \n1 Nuclear medicine department and Molecular Imaging Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Galicia, Spain  \n2 Critical Path for Alzheimer’s Disease (CPAD) Consortium, Critical Path Institute, Tucson, AZ, USA  \n3 Critical Path Institute, Tucson, AZ, USA  \n4 Eli Lilly and Company, Indianapolis, IN, USA  \n5The University of Pittsburgh, Pittsburgh, PA, USA  \n6 Roche Pharma Research and Early Development, FHoffmann-La RocheLtd, Basel, Switzerland  \n7 Roche Pharma Research and Early Development, Neuroscience and Rare Diseases Biomarkers, F. Hoffmann-La Roche Ltd., Basel, Switzerland  \n8 Genentech, Inc., San Francisco, CA, USA  \n9 Lawrence Berkeley National Laboratory, Berkeley, CA, USA  \n10Johnson & Johnson Innovative Medicine, San Diego, CA, USA  \n11 Life Molecular Imaging GmbH, Berlin, Germany  \n12 University of Pittsburgh, Pittsburgh, PA, USA  \n13 Genentech, San Fransisco, CA, USA  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Alzheimer’s Association. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association.  \nAlzheimer’s Dement. 2025;21(Suppl. 2):e106362. wi[leyonlinelibrary.com/journal/alz](leyonlinelibrary.com/journal/alz) 1of6  \n[https://doi.org/10.1002/alz70856_106362](https://doi.org/10.1002/alz70856_106362)  \n2of6 BIOMARKERS  \n14 University of Chicago, Chicago, IL, USA  \n15 Genentech, Inc, San Francisco, CA, USA  \n16Ace Alzheimer Center Barcelona-Universitat Internacional de Catalunya, Barcelona, Spain  \n17 University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA  \n18 Eisai Inc., Nutley, NJ, USA  \n19 Biogen, Cambridge, MA, USA  \n20Xing Imaging – A Mitro Company, London, United Kingdom  \n21 National Institutes for Quantum Science and Technology, Chiba, Japan  \n22 Merck Sharp & Dohme LLC, West Point, PA, USA  \n23 University of California, San Francisco, San Francisco, CA, USA  \n24 Eisai Inc., Woodcliff Lake, NJ, USA  \n25 Mayo Clinic, Rochester, MN, USA  \n26 Neuroscience Department, University of California, Berkeley, Berkeley, CA, USA  \n27 Center for Alzheimer’s Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA  \n28 Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA  \n29Ace Alzheimer Center Barcelona, Barcelona, Spain  \n30 Enigma Biomedical Group, Knoxville, TN, USA  \n31Amsterdam University Medical Center, Amsterdam, Netherlands  \n32 Clinical Memory Research Unit, Department of Clinical","cbCaikjKwbaKN1Q2","https://ap.wps.com/l/cbCaikjKwbaKN1Q2","pdf",5316611,"English","# Abstract\n## Background\n## Objective\n## Methods and Results\n## Conclusions","[{\"question\":\"What is the purpose of the CenTauR scale in tau-PET imaging?\",\"answer\":\"The CenTauR scale is designed to harmonize tau-PET quantification across different radiotracers. This helps make measurements more comparable.\"},{\"question\":\"What does this poster focus on?\",\"answer\":\"It focuses on external validation of the JPM-based CenTauR units. The goal is to test performance beyond the original development setting.\"},{\"question\":\"How is the validation intended to support research use?\",\"answer\":\"By evaluating consistency and robustness across sites and datasets, the poster aims to support standardized tau-PET quantification for multicenter studies.\"}]","External Validation of Joint Propagation Model-Based Tau PET CenTauR units - Poster Presentation | PDF",15]