[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-374533-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-374533-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","expression-patterns-of-immune-checkpoint-molecules-and-their-clinical-values-in-gastric-neuroendocrine-neoplasms","Expression Patterns of Immune Checkpoint Molecules and Their Clinical Values in Gastric Neuroendocrine Neoplasms","","Gastric neuroendocrine neoplasms are rare, and limited evidence links B7 family ligands and receptors to their clinical relevance. This study assessed immune checkpoint markers in 112 gastric neuroendocrine neoplasm samples by immunohistochemistry, quantifying PD-L1, PD-L2, B7-H3, B7-H4, LGALS9, and CD155. High expression levels were frequent and associated with multiple clinicopathological features, while survival analyses identified prognostic relationships. Multivariate models indicated CD155 and additional factors as independent predictors of overall survival.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/expression-patterns-of-immune-checkpoint-molecules-and-their-clinical-values-in-gastric-neuroendocrine-neoplasms/374533/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/expression-patterns-of-immune-checkpoint-molecules-and-their-clinical-values-in-gastric-neuroendocrine-neoplasms/374533.png","ImageObject",300,407,{"name":42,"@type":43},"Quinn Holloway","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-28","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Which immune checkpoint molecules were evaluated in gastric neuroendocrine neoplasms?","Question",{"text":63,"@type":64},"The study quantified PD-L1, PD-L2, B7-H3, B7-H4, LGALS9 (galectin-9), and CD155 in 112 g-NEN samples using immunohistochemistry.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were the marker levels related to clinicopathological features?",{"text":68,"@type":64},"Elevated expression of the studied markers was significantly associated with several clinicopathological characteristics across the cohort.",{"name":70,"@type":61,"acceptedAnswer":71},"Which factors were independent predictors of overall survival?",{"text":72,"@type":64},"Multivariate Cox regression indicated high CD155 expression, vasculature invasion, and worse World Health Organization pathological grade as independent prognostic factors for overall survival.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},374533,1790241296,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},2336474466712,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","ARTICLE 1  \n\n| INTRODUCTION: Gastric neuroendocrine neoplasms (g-NENs) are a rare type of stomach tumor. However, limited data exist about the expression and clinical significance of B7 family ligands/receptors in patients with g-NENs. Thus, we conducted this study to address this issue in a cohort of 112 patients with g-NENs.\u003Cbr>METHODS: Using immunohistochemistry, we mapped and quantified the expression of the B7 family ligands/\u003Cbr>receptors in 112 g-NEN samples: programmed cell death ligand 1 and 2 (PD-L1 and PD-L2), B7-H3, B7-H4, recombinant human galectin-9 (LGALS9), and CD155 . Associations between the marker levels, clinicopathological variables, and survival were evaluated. |\n| --- |\n| |\n| |\n| |\n|  |\n\nExpression Patterns of Immune Checkpoint Molecules and Their Clinical Values in Gastric  \nNeuroendocrine Neoplasms  \nMengjie Liang, PhD1 , *, Junren Lu, MD1 , *, Xingzhou Wang, PhD1 , *, Peng Song, PhD 1 , *, Shichao Ai, PhD1 , *, Daming Cai, PhD1 ,  \nFeng Sun, PhD1, Xiaofeng Lu, PhD1, Meng Wang, PhD1, Shuang Fu, BM2, Heng Yu, MD1, Wenxian Guan, PhD1 and Xiaofei Shen, PhD1 ,3  \nSTOMACH  \n1Department of General Surgery, Division of Gastric Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Nanjing University, Nanjing, China; 2Department of Anesthesiology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Nanjing University, Nanjing, China; 3Department of General Surgery, Division of Gastric Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China.  \nCorrespondence: Xiaofei Shen. E-mail: [dg1535058@smail.nju.edu.cn](dg1535058@smail.nju.edu.cn); Heng Yu, PhD. E-mail: [yuhmed@163.com](yuhmed@163.com); Wenxian Guan. E-mail: 15850502391@  \n[163.com](163.com); Shuang Fu. E-mail: [13764038@qq.com](13764038@qq.com).  \n*Mengjie Liang, Junren Lu, Xingzhou Wang, Peng Song, and Shichao Ai contributed equally as co-first author.  \nReceived October 10, 2024; accepted March 27, 2025; published online April 4, 2025  \n© 2025 The Author(s) . Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology  \nAmerican College of Gastroenterology Clinical and Translational Gastroenterology  \nSTOMACH  \nRESULTS: The percentages of high expression of PD-L1, PD-L2, B7-H3, B7-H4, LGALS9, and CD155 in the  \ncohort of 112 g-NEN cases were 37.5%, 55.4%, 46.4%, 37.5%, 46.4%, and 51.8%, respectively. Elevated expression of PD-L1, PD-L2, B7-H3, B7-H4, LGALS9, and CD155 was significantly associated with several clinicopathological characteristics. K-M analysis indicated that high expression levels of CD155, B7-H3, PD-L2, and LGALS9 were correlated with poor overall survival (OS) (P\u003C 0.0001, P 5 0.0002, P 5 0.0319 and P 5 0.0120, respectively) . Multivariate Cox regression analysis indicated that high CD155 expression, vasculature invasion, and worse World Health Organization pathological grade were independent prognostic factors for OS(P 5 0.007, P 5 0.030, and P 5 0.019, respectively) .  \nDISCUSSION: We detected variable expression of the PD-L1, PD-L2, B7-H3, B7-H4, LGALS9, and CD155 proteins ing-NENs. These results suggest that the expression level of CD155 may be a vital indicator of OS inpatients with g-NENs. B7 family ligands/receptors could be potential immunotherapeutic targets for g-NENs.  \nKEYWORDS: B7 family receptors/ligands; gastric neuroendocrine neoplasms; overall survival; immunotherapy  \nClinical and Translational Gastroenterology 2025;16:e00842. [https://doi.org/10.14309/ctg.0000000000000842](https://doi.org/10.14309/ctg.0000000000000842)  \nINTRODUCTION  \nGastroenteropancreatic neuroendocrine tumors (NETs), which include gastric neuroendocrine neoplasms (g-NENs), are increasingly common(1) . G-NENS are neoplasms derived from the enterochromaffin-like cells of the gastric mucosa. These tumors are rare lesions with indolent behavior and neuroendocrine differentiation. Gastric NETs are relatively rare lesions","cbCairiOWgrTwec4","https://ap.wps.com/l/cbCairiOWgrTwec4","pdf",1178495,11,"English","# Introduction\n## Gastric neuroendocrine neoplasms and clinical subtypes\n## WHO histological grading and prognosis\n## Management approaches and immunotherapy context\n# Methods\n## Immunohistochemistry cohort and marker panel\n## Associations with clinicopathological variables and survival\n# Results\n## Expression rates of PD-L1/PD-L2 and B7 family ligands\n## Survival associations from Kaplan-Meier and Cox models\n# Discussion\n## Interpretation of checkpoint expression and clinical indicator potential","[{\"question\":\"Which immune checkpoint molecules were evaluated in gastric neuroendocrine neoplasms?\",\"answer\":\"The study quantified PD-L1, PD-L2, B7-H3, B7-H4, LGALS9 (galectin-9), and CD155 in 112 g-NEN samples using immunohistochemistry.\"},{\"question\":\"How were the marker levels related to clinicopathological features?\",\"answer\":\"Elevated expression of the studied markers was significantly associated with several clinicopathological characteristics across the cohort.\"},{\"question\":\"Which factors were independent predictors of overall survival?\",\"answer\":\"Multivariate Cox regression indicated high CD155 expression, vasculature invasion, and worse World Health Organization pathological grade as independent prognostic factors for overall survival.\"}]","Expression Patterns of Immune Checkpoint Molecules and Their Clinical Values in Gastric Neuroendocrine Neoplasms | PDF",1790201846,28]