[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-344672-105":59,"doc-detail-344672-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","expression-of-pluripotency-stem-cell-markers-in-endometrial-hyperplasia-research-findings","Expression of pluripotency stem cell markers in endometrial hyperplasia - Research findings","","Endometrial hyperplasia, a precursor to endometrial cancer, is rising alongside obesity and lifestyle risks, yet molecular characterization remains limited for prognosis and prevention. Using a case-control design with archival endometrial tissue blocks, the study assessed immunohistochemical expression of NANOG, OCT4, and SOX2 in hyperplastic versus benign non-hyperplastic endometrium from women with abnormal uterine bleeding.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/expression-of-pluripotency-stem-cell-markers-in-endometrial-hyperplasia-research-findings/344672/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/expression-of-pluripotency-stem-cell-markers-in-endometrial-hyperplasia-research-findings/344672.png","ImageObject",300,407,{"name":92,"@type":93},"Himbo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Which pluripotency stem cell markers were evaluated in endometrial hyperplasia?","Question",{"text":113,"@type":114},"The study examined immunohistochemical expression of NANOG, OCT4, and SOX2 in hyperplastic endometrium compared with benign non-hyperplastic endometrium.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What did the results show about NANOG and risk prediction?",{"text":118,"@type":114},"NANOG demonstrated moderate to high expression in a significantly higher proportion of endometrial hyperplasia cases than controls, and logistic regression indicated that age and NANOG expression predicted hyperplasia risk.",{"name":120,"@type":111,"acceptedAnswer":121},"How were OCT4, SOX2, and age related to endometrial hyperplasia in this study?",{"text":122,"@type":114},"OCT4 showed a modest increase in hyperplasia cases versus controls, while SOX2 did not differ significantly. Receiver operating characteristic analyses indicated age-related associations, including prediction of SOX2 expression and diagnostic discrimination performance.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},344672,1790097320,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","Expression of pluripotency stem cell markers in endometrial hyperplasia  \nWomen’s Health Volume 22: 1–11 © The Author(s) 2026 Article reuse guidelines:  \n[sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/17455057251408631](DOI: 10.1177/17455057251408631)[ ](DOI: 10.1177/17455057251408631)[journals.sagepub.com/home/whe](journals.sagepub.com/home/whe)  \nNoha A. Mousa 1,2, Zeinab Al-Rawi 1, Amal Hussein3, Abdalla Suliman4, Ghada Mohammed 1,2, Rifat Hamoudi4,5,6 and Suha Al-Naimi7,8  \nAbstract  \nBackground: Endometrial hyperplasia, a precursor to endometrial cancer, is increasing due to rising obesity and lifestyle risks. Scarce data exist on the molecular characterization of endometrial hyperplasia for prognostic and preventive applications, Objectives: This study investigates the expression of core pluripotency stem cell markers in endometrial hyperplasia, given their emerging role in cancer stem cell regulation in various cancers, including endometrial cancer,  \nDesign: This is a case–control study utilizing archival endometrial tissue blocks. In this study, we assessed the immunohistochemical expression of NANOG, OCT4, and SOX2 in hyperplastic endometrium compared to benign non-hyperplastic endometrium obtained from women with abnormal uterine bleeding,  \nResults: The investigation included 165 patients (83 cases with endometrial hyperplasia and 82 controls). The prevalence of endometrial hyperplasia in our cohort was 20.8%(of 500 patients). NANOG showed moderate to high expression in 60.2% of endometrial hyperplasia cases, significantly higher than in controls (19.5%), p \u003C 0.0005. OCT4 showed moderate/ high expression in 12% of endometrial hyperplasia cases compared to 3.7% of controls (p = 0.045). In comparison, SOX2 was expressed in 18% of endometrial hyperplasia with no significant difference from controls (19.7%), p = 0.823. Logistic regression showed that age and NANOG expression were significant predictors of endometrial hyperplasia risk, with women exhibiting moderate/high NANOG expression having an 11-fold increased risk of endometrial hyperplasia (95% confidence interval of odds ratio: 3.484–35.864, p \u003C 0.001). Using receiver operating characteristic curves, women’s age predicted SOX2 expression in endometrial hyperplasia cases (area under the curve (AUC) = 0.867, cutoff = 49 years, Youden’s index = 0.722, sensitivity = 100%, specificity = 72.2%, p \u003C 0.001), and NANOG in controls (AUC = 0.734, cutoff = 42 years, Youden’s index = 0.37, sensitivity = 68.8%, specificity = 68.2%, p = 0.004).  \nConclusion: NANOG shows promise for a potential predictive role in patients with endometrial hyperplasia, with moderate/high expression indicating a higher risk. SOX2’s role was unclear but age-related. Further studies are needed to validate these findings and explore hormonal links.  \nPlain language summary  \nEmbryonic Stem Cell Markers and Endometrial Hyperplasia  \nFindings suggest a potential role for these markers, particularly NANOG, in endometrial hyperplasia. NANOG may have prognostic value in stratifying risk for women with abnormal uterine bleeding, pending further clinical validation. Prospective studies are needed to confirm these findings and assess clinical translation. The pluripotency stem cell markers have been studied in several gynecologic and other cancers, but limited data exist on their expression in pre-cancerous  \n1 Department of Clinical Sciences, College of Medicine, University of Sharjah, United Arab Emirates  \n2Department of Obstetrics and Gynecology, University Hospital Sharjah, United Arab Emirates  \n3Department of Family & Community Medicine and Behavioral Sciences, College of Medicine, University of Sharjah, United Arab Emirates 4Center of Excellence for Precision Medicine, Research Institute of Medical and Health Sciences, University of Sharjah, United Arab Emirates 5Division of Surgery and Interventional Science, Faculty of Medical","cbCaio9agQzTHjVi","https://ap.wps.com/l/cbCaio9agQzTHjVi","pdf",1672136,11,"English","# Abstract\n## Background\n## Design and Methods\n## Results\n## Conclusion\n# Plain language summary\n## Findings\n## Clinical implications\n# Introduction","[{\"question\":\"Which pluripotency stem cell markers were evaluated in endometrial hyperplasia?\",\"answer\":\"The study examined immunohistochemical expression of NANOG, OCT4, and SOX2 in hyperplastic endometrium compared with benign non-hyperplastic endometrium.\"},{\"question\":\"What did the results show about NANOG and risk prediction?\",\"answer\":\"NANOG demonstrated moderate to high expression in a significantly higher proportion of endometrial hyperplasia cases than controls, and logistic regression indicated that age and NANOG expression predicted hyperplasia risk.\"},{\"question\":\"How were OCT4, SOX2, and age related to endometrial hyperplasia in this study?\",\"answer\":\"OCT4 showed a modest increase in hyperplasia cases versus controls, while SOX2 did not differ significantly. Receiver operating characteristic analyses indicated age-related associations, including prediction of SOX2 expression and diagnostic discrimination performance.\"}]","Expression of pluripotency stem cell markers in endometrial hyperplasia - Research findings | PDF",1790054819,28]