[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-338230-105":59,"doc-detail-338230-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","expression-and-targeted-application-of-claudins-family-in-hepatobiliary-and-pancreatic-diseases","Expression and Targeted Application of Claudins Family in Hepatobiliary and Pancreatic Diseases","","Hepatobiliary and pancreatic diseases continue to rise globally, and the cancers they involve are prone to recurrence and metastasis, with low survival after diagnosis. Tight junction claudins (CLDNs) are membrane proteins essential for intercellular barrier formation and for maintaining cellular polarity. In mammals, the claudin family comprises at least 27 transmembrane proteins and influences cell adhesion and paracellular permeability. Claudin alterations are linked to the development of hepatobiliary and pancreatic cancers. This review summarizes functional phenotypes, molecular mechanisms, and targeted applications, highlighting claudin-1, claudin-4, claudin-7, and claudin-18.2 while outlining current progress and future prospects.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/expression-and-targeted-application-of-claudins-family-in-hepatobiliary-and-pancreatic-diseases/338230/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/expression-and-targeted-application-of-claudins-family-in-hepatobiliary-and-pancreatic-diseases/338230.png","ImageObject",300,407,{"name":92,"@type":93},"Riley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are new therapeutic strategies needed for hepatobiliary and pancreatic diseases?","Question",{"text":112,"@type":113},"Associated cancers are commonly diagnosed at advanced stages, and poor outcomes are driven by recurrence and metastasis, including processes such as epithelial-mesenchymal transition (EMT). The review emphasizes that more accurate treatments require new therapeutic strategies.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What role do claudins play in tight junctions and cancer-related processes?",{"text":117,"@type":113},"Claudins are key components of tight junctions that mediate cell adhesion and paracellular permeability. Altered claudin expression can contribute to loss of cell adhesion, structural disruption, and promotion of metastasis.",{"name":119,"@type":110,"acceptedAnswer":120},"Which claudin members receive special emphasis for targeted application?",{"text":121,"@type":113},"The review emphasizes claudin-1, claudin-4, claudin-7, and claudin-18.2. It discusses their functional roles and their potential as diagnostic or therapeutic targets.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},338230,1790111521,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1374391975076,"https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051","Journal of Hepatocellular Carcinoma Dovepress  \nopen access to scientific and medical research  \n Open Access Full Text Article REVIEW  \nExpression and Targeted Application of Claudins Family in Hepatobiliary and Pancreatic Diseases  \nFangqian Du 1 , *, Yuwei Xie 1 , *, Shengze Wu 1 , Mengling Ji 2 , Bingzi Dong 3 , Chengzhan Zhu 1  \n1Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 2Department of Surgery, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan; 3Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China  \n*These authors contributed equally to this work  \nCorrespondence: Chengzhan Zhu, Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China, Tel +86 0532-82919552, Fax +86 0532-82911885, Email [zhuchengz@qduhospital.cn](zhuchengz@qduhospital.cn); Bingzi Dong, Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China, Tel/Fax +86-82911383,  \nEmail [dongbingzi@hotmail.com](dongbingzi@hotmail.com)  \n\n| Abstract: Hepatobiliary and pancreatic diseases are becoming increasingly common worldwide and associated cancers are prone to recurrence and metastasis. For a more accurate treatment, new therapeutic strategies are urgently needed. The claudins (CLDN) family comprises a class of membrane proteins that are the main components of tight junctions, and are essential for forming intercellular barriers and maintaining cellular polarity. In mammals, the claudin family contains at least 27 transmembrane proteins and plays a major role in mediating cell adhesion and paracellular permeability. Multiple claudin proteins are altered in various cancers, including gastric cancer (GC), esophageal cancer (EC), hepatocellular carcinoma (HCC), pancreatic cancer (PC), colorectal cancer (CRC) and breast cancer (BC) . An increasing number of studies have shown that claudins are closely associated with the occurrence and development of hepatobiliary and pancreatic diseases. Interestingly, claudin proteins exhibit different effects on cancer progression in different tumor tissues, including tumor suppression and promotion. In addition, various claudin proteins are currently being studied as potential diagnostic and therapeutic targets, including claudin-3, claudin-4, claudin-18.2, etc. In this article, the functional phenotype, molecular mechanism, and targeted application of the claudin family in hepatobiliary and pancreatic diseases are reviewed, with an emphasis on claudin-1, claudin-4, claudin-7 and claudin-18.2, and the current situation and future prospects are proposed. Keywords: claudins, hepatocellular carcinoma, cholangiocarcinoma, pancreatic cancer, targeted therapy |\n| --- |\n| Introduction\u003Cbr>Hepatobiliary pancreas-related diseases are becoming more common in modern societies and the associated tumors are highly malignant. Most patients are at an advanced stage when diagnosed, and the 5-year survival rate is low, which seriously threatens quality of life.1 The main causes of death in patients with hepatobiliary and pancreatic tumors are recurrence and metastasis, and epithelial-mesenchymal transition (EMT) is crucial for the migration and metastasis of cancer cells.2 Specifically, EMT is a process of transformation of epithelial cells into mesenchymal cells, in which epithelial cells lose apical cell polarity, lose adhesion, and acquire the mesenchymal cell phenotype, thus gaining cell migration abilities, which promotes metastasis and drug resistance.3 This process is largely dependent on the breakdown and loss of tight junctions (TJs) between cells.\u003Cbr>TJs are intercellular connection device that provides barrier and/or channel functions in the paracellular cleft and facilitates the maintenance of cell polarit","cbCaifRHmeVaYwqz","https://ap.wps.com/l/cbCaifRHmeVaYwqz","pdf",4529199,21,"English","# Abstract\n# Introduction","[{\"question\":\"Why are new therapeutic strategies needed for hepatobiliary and pancreatic diseases?\",\"answer\":\"Associated cancers are commonly diagnosed at advanced stages, and poor outcomes are driven by recurrence and metastasis, including processes such as epithelial-mesenchymal transition (EMT). The review emphasizes that more accurate treatments require new therapeutic strategies.\"},{\"question\":\"What role do claudins play in tight junctions and cancer-related processes?\",\"answer\":\"Claudins are key components of tight junctions that mediate cell adhesion and paracellular permeability. Altered claudin expression can contribute to loss of cell adhesion, structural disruption, and promotion of metastasis.\"},{\"question\":\"Which claudin members receive special emphasis for targeted application?\",\"answer\":\"The review emphasizes claudin-1, claudin-4, claudin-7, and claudin-18.2. It discusses their functional roles and their potential as diagnostic or therapeutic targets.\"}]","Expression and Targeted Application of Claudins Family in Hepatobiliary and Pancreatic Diseases | PDF",1790022652,53]