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This case-control study investigated PEDF, VEGF, and CD31-stained microvessel density across normal mucosa, colorectal adenoma, and CRC. Archived specimens (April–October 2022) underwent immunohistochemistry, with statistical comparisons and correlation analyses to define expression patterns and clinicopathological associations.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/expression-and-significance-of-pigment-epithelium-derived-factor-and-vascular-endothelial-growth-factor-in-colorectal-adenoma-and-cancer/375729/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/expression-and-significance-of-pigment-epithelium-derived-factor-and-vascular-endothelial-growth-factor-in-colorectal-adenoma-and-cancer/375729.png","ImageObject",300,407,{"name":92,"@type":93},"Riley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the purpose of comparing PEDF, VEGF, and CD31-MVD across groups?","Question",{"text":113,"@type":114},"To determine how PEDF, VEGF, and CD31-stained microvessel density differ between normal colorectal mucosa, colorectal adenoma, and colorectal cancer, and to assess their significance.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were specimens selected and what experimental method was used?",{"text":118,"@type":114},"Archived wax blocks from April 2022 to October 2022 were selected into normal, adenoma, and CRC groups. Immunohistochemical staining was used to detect PEDF and VEGF expression.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the main findings about PEDF and VEGF expression?",{"text":122,"@type":114},"PEDF expression decreased progressively from normal mucosa to adenoma to CRC, while VEGF expression increased across the same groups. PEDF and VEGF also showed associations with CRC differentiation, invasion, metastasis, and TNM stage.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},375729,1790318815,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},1374391975076,"https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051","| W | J | G | O | World Journal of\u003Cbr>Gastrointestinal Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Oncol 2024 March 15; 16(3): 670-686  \nDOI: 10.4251/wjgo.v16.i3.670 ISSN 1948-5204 (online)  \nORIGINAL ARTICLE  \nCase Control Study  \nExpression and significance of pigment epithelium-derived factor and vascular endothelial growth factor in colorectal adenoma and cancer  \nYe Yang, Wu Wen, Feng-Lin Chen, Ying-Jie Zhang, Xiao-Cong Liu, Xiao-Yan Yang, Shan-Shan Hu, Ye Jiang, Jing Yuan  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): 0  \nGrade B (Very good): B  \nGrade C (Good): 0  \nGrade D (Fair): 0  \nGrade E (Poor): 0  \nP-Reviewer: Šarenac TM, Serbia  \nReceived: November 7, 2023  \nPeer-review started: November 7, 2023  \nFirst decision: December 31, 2023  \nRevised: January 16, 2024  \nAccepted: February 4, 2024  \nArticle in press: February 4, 2024  \nPublished online: March 15, 2024  \nYe Yang, Digestive Diseases, Chengdu Qingbaijiang District People's Hospital, Chengdu 610300, Sichuan Province, China  \nWu Wen, Ying-Jie Zhang, Xiao-Cong Liu, Xiao-Yan Yang, Shan-Shan Hu, Ye Jiang, Jing Yuan,  \nDigestive Diseases, Chengdu Second People’s Hospital, Chengdu 610000, Sichuan Province, China  \nFeng-Lin Chen, Graduate School, Chengdu Medical College, Chengdu 610000, Sichuan Province, China  \nCorresponding author: Wu Wen, Doctor, Chief Physician, Digestive Diseases, Chengdu Second People’s Hospital, No. 10 Qingyunan Street, Jinjiang District, Chengdu 610000, Sichuan Province, [China.](China. wenwu2@qq.com)[ wenwu2@qq.com](China. wenwu2@qq.com)  \nAbstract  \nBACKGROUND  \nThe incidence and mortality of colorectal cancer (CRC) are among the highest in the world, and its occurrence and development are closely related to tumor neovascularization. When the balance between pigment epithelium-derived factors (PEDF) that inhibit angiogenesis and vascular endothelial growth factors (VEGF) that stimulate angiogenesis is broken, angiogenesis is out of control, resulting in tumor development. Therefore, it is very necessary to find more therapeutic targets for CRC for early intervention and later treatment.  \nAIM  \nTo investigate the expression and significance of PEDF, VEGF, and CD31-stained microvessel density values (CD31-MVD) in normal colorectal mucosa, adenoma, and CRC.  \nMETHODS  \nIn this case-control study, we collected archived wax blocks of specimens from the Digestive Endoscopy Center and the General Surgery Department of Chengdu Second People's Hospital from April 2022 to October 2022. Fifty cases of specimen wax blocks were selected as normal intestinal mucosa confirmed by electronic colonoscopy and concurrent biopsy (normal control group), 50 cases of specimen  \n WJGO  [https://www.wjgnet.com](https://www.wjgnet.com) 670 March 15, 2024  Volume 16  Issue 3   \nYang Y et al. PEDF and VEGF in CRC  \nwax blocks were selected as colorectal adenoma confirmed by electronic colonoscopy and pathological biopsy (adenoma group), and 50 cases of specimen wax blocks were selected as CRC confirmed by postoperative pathological biopsy after inpatient operation of general surgery (CRC group) . An immunohistochemical staining experiment was carried out to detect PEDF and VEGF expression in three groups of specimens, analyze their differences, study the relationship between the two and clinicopathological factors in CRC group, record CD31-MVD in the three groups, and analyze the correlation of PEDF, VEGF, and CD31-MVD in the colorectal adenoma group and the CRC group. The F test or adjusted F test is used to analyze measurement data statistically. KruskalWallis rank sum test was used between groups for ranked data. The chi-square test, adjusted chi-square test, or Fisher's e","cbCairlEZtwmFRVO","https://ap.wps.com/l/cbCairlEZtwmFRVO","pdf",26774640,18,"English","# Abstract\n## Background\n## Aim\n## Methods\n## Results\n## Conclusion","[{\"question\":\"What was the purpose of comparing PEDF, VEGF, and CD31-MVD across groups?\",\"answer\":\"To determine how PEDF, VEGF, and CD31-stained microvessel density differ between normal colorectal mucosa, colorectal adenoma, and colorectal cancer, and to assess their significance.\"},{\"question\":\"How were specimens selected and what experimental method was used?\",\"answer\":\"Archived wax blocks from April 2022 to October 2022 were selected into normal, adenoma, and CRC groups. Immunohistochemical staining was used to detect PEDF and VEGF expression.\"},{\"question\":\"What were the main findings about PEDF and VEGF expression?\",\"answer\":\"PEDF expression decreased progressively from normal mucosa to adenoma to CRC, while VEGF expression increased across the same groups. PEDF and VEGF also showed associations with CRC differentiation, invasion, metastasis, and TNM stage.\"}]","Expression and significance of pigment epithelium-derived factor and vascular endothelial growth factor in colorectal adenoma and cancer | PDF",1790215930,45]