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This study evaluates expression levels and functions of miR-205, miR-376c, and miR-539 in CRC development and prognosis using multiple GEO databases, bioinformatics, and clinicopathological correlation. Data from 25 CRC patients were analyzed, revealing shared and distinct associations with tumor progression and metastatic behavior.",{"@graph":69,"@context":121},[70,84,104],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/expression-and-significance-analyses-of-micrornas-in-colorectal-cancer-research/358757/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":98,"encodingFormat":97,"isAccessibleForFree":99,"interactionStatistic":100},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/expression-and-significance-analyses-of-micrornas-in-colorectal-cancer-research/358757.png","ImageObject",300,407,{"name":92,"@type":93},"Asher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23",true,{"@type":101,"interactionType":102,"userInteractionCount":8},"InteractionCounter",{"@type":103},"ViewAction",{"@type":105,"mainEntity":106},"FAQPage",[107,113,117],{"name":108,"@type":109,"acceptedAnswer":110},"What is the main objective of the study on miRNAs in colorectal cancer?","Question",{"text":111,"@type":112},"To investigate the expression levels and functions of miR-205, miR-376c, and miR-539 in colorectal cancer development and prognosis.","Answer",{"name":114,"@type":109,"acceptedAnswer":115},"Which datasets and methods were used to explore miRNA expression and associations?",{"text":116,"@type":112},"Multiple GEO databases were used to examine miRNA expression in CRC and adjacent/normal tissues, followed by bioinformatics analyses and clinicopathological association testing.",{"name":118,"@type":109,"acceptedAnswer":119},"What expression pattern did the study observe for the three miRNAs in tumor tissues?",{"text":120,"@type":112},"In the GSE41655 dataset, miR-376c, miR-539, and miR-205 were all downregulated in tumor tissues, with miR-376c showing the most pronounced decrease.","https://schema.org",{"og:url":83,"og:type":123,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":125,"canonical":83},"index,follow",{"doc_id":127,"site_id":62},358757,1790164186,{"code":4,"msg":5,"data":130},{"doc_id":127,"user_id":131,"nickname":92,"user_avatar":132,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":133,"file_id":134,"file_url":135,"file_type":136,"file_size":137,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":138,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},687197207639,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","MOLECULAR AND CLINICAL ONCOLOGY 24: 20, 2026  \nExpression and significance analyses of microRNAs in colorectal cancer  \nJING ZHANG 1* , LIWEI SUN2* , CHANGXIU YAN2* , HONGGANG RAN3 , KAIYONG QU3 , ZHIJIAN CHEN3 , ARGEN BAHET3 , CHENXI WANG3 , XIN CAI3 , GUOHONG ZHUANG2 and ZEYANG LIN4  \n1  \nDepartment of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian 361000, P.R. China; 2Organ Transplantation Institute of Xiamen University,  \nFujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Xiamen University, Xiamen, Fujian 361000, 3 4  \nP.R. China; School of Medicine, Xiamen University, Xiamen, Fujian 361000, P.R. China; Department of Pathology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361000, P.R. China  \nReceived June 4, 2025; Accepted January 8, 2026  \nDOI: 10. 3892/mco.2026.2929  \nAbstract. MicroRNAs (miRNAs or miRs) serve as potential diagnostic and prognostic markers or therapeutic targets . However, their roles in the pathogenesis of colorectal cancer (CRC) is not fully understood. The aim of the present study was to investigate the expression levels and functions of miR‑205, miR‑376c, and miR‑539 in CRC development and prognosis . Multiple GEO databases were used to explore miRNA expression levels and associations in CRC cancer and adjacent/normal tissues. In addition, the associations between the expression of the miRNAs and the clinicopathological features of CRC were analyzed. The clinical data and speci‑ mens of 25 patients with CRC were collected, detected and analyzed. Combining bioinformatics analysis and databases, the relationship between the three miRNAs and CRC progres‑ sion and prognosis was explored. In the GSE41655 dataset, miR‑376c, miR‑539, and miR‑205 were all downregulated in tumor tissues, with miRNA‑376c exhibiting the most pronounced downregulation. MiR‑376c was closely associated with CRC liver metastasis, especially in the synchronous metastasis condition. Additionally, in the miRDB database,  \nCorrespondence to: Dr Guohong Zhuang, Organ Transplantation Institute of Xiamen University, Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Xiamen University, 42 Siming South Road, Haibin Street, Xiamen, Fujian 361000, P.R. China  \nE‑mail: [zhgh@xmu.edu.cn](zhgh@xmu.edu.cn)  \nDr Zeyang Lin, Department of Pathology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, 201 Hubin South Road, Kaiyuan Street, Xiamen, Fujian 361000, P.R. China  \nE‑mail: [zeyanglin@xmu.edu.cn](zeyanglin@xmu.edu.cn)  \n*Contributed equally  \nKey words: colorectal cancer, miR‑205, miR‑376c, miR‑539  \nan analysis of the overlapping predicted target genes for miR‑205, miR‑376c, and miR‑539 revealed that these three miRNAs share 53 common predicted target genes. Not only did miR‑539 and miR‑205 significantly differ according to tumor stage and lymph node metastasis, but also their upregu‑ lation was significant in tumor advanced stage and lymph node metastasis according to logistic regression in collected cancer tissues. Furthermore, miR‑205 was significantly upregulated in tumor differentiation according to logistic regression. In conclusion, miR‑205, miR‑376c, and miR‑539 were revealed tobe involved in the development and prognosis ofCRC and maybe potential targets for CRC therapy.  \nIntroduction  \nColorectal cancer (CRC) is one of the most common types of malignant tumors of the digestive tract and ranks third among new estimated cases and deaths among men and women globally. At first, most patients with CRC in stages I and II undergo only partial or total colectomy, and then approximately two‑thirds with stage III undergo chemotherapy to reduce the risk of recurrence. Ultimately, chemotherapy is the main treat‑ ment of patients with CRC in stage IV. With ~2 million new cases and 1 ","cbCailQDa2wToeiH","https://ap.wps.com/l/cbCailQDa2wToeiH","pdf",4288156,13,"English","# Abstract\n## Introduction\n## MicroRNAs and their roles in CRC\n## Study focus on miR-205, miR-376c, and miR-539","[{\"question\":\"What is the main objective of the study on miRNAs in colorectal cancer?\",\"answer\":\"To investigate the expression levels and functions of miR-205, miR-376c, and miR-539 in colorectal cancer development and prognosis.\"},{\"question\":\"Which datasets and methods were used to explore miRNA expression and associations?\",\"answer\":\"Multiple GEO databases were used to examine miRNA expression in CRC and adjacent/normal tissues, followed by bioinformatics analyses and clinicopathological association testing.\"},{\"question\":\"What expression pattern did the study observe for the three miRNAs in tumor tissues?\",\"answer\":\"In the GSE41655 dataset, miR-376c, miR-539, and miR-205 were all downregulated in tumor tissues, with miR-376c showing the most pronounced decrease.\"}]","Expression and significance analyses of microRNAs in colorectal cancer - Research | PDF",1790135203,33]