[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-454476-105":59,"doc-detail-454476-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","exposure-to-organochlorine-compounds-in-relation-to-weight-maintenance","Exposure to organochlorine compounds in relation to weight maintenance","","The study tests whether exposure to organochlorine compounds is associated with body weight increases during a dietary intervention. In the DioGenes trial, adults with obesity who achieved at least 8% weight loss then followed a specific diet for 26 weeks. Major organochlorines in baseline plasma from 372 participants were analyzed. Total-PCB doubling correlated with greater weight gain at 26 weeks, while most single compounds were weakly or not statistically significant after PFAS adjustment; p,p’-DDE showed an inverse association. Findings suggest halogenated pollutants may contribute to obesity risk.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/exposure-to-organochlorine-compounds-in-relation-to-weight-maintenance/454476/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/exposure-to-organochlorine-compounds-in-relation-to-weight-maintenance/454476.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn Holloway","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What hypothesis does the study test about organochlorine exposure and weight?","Question",{"text":112,"@type":113},"It tests whether exposures to organochlorine compounds are associated with body weight increases during a dietary intervention study.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were organochlorine compounds measured and when?",{"text":117,"@type":113},"Concentrations of major organochlorine compounds were assessed in plasma samples obtained at study baseline.",{"name":119,"@type":110,"acceptedAnswer":120},"What key pattern did the study observe regarding PCBs and p,p’-DDE?",{"text":121,"@type":113},"A doubling in total-PCB was associated with increased weight at 26 weeks, while p,p’-DDE showed the opposite effect, linking to lower body weight.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},454476,1792212077,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},2336474466712,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","University of Southern Denmark  \nSDU  \nNovo Nordisk Foundation [https://orcid.org/0000-0001-8968-8996](https://orcid.org/0000-0001-8968-8996)  \ndiet modi«cation, obesogens, polychlorinated hydrocarbons, randomized clinical trial, weight gain  \n December 12th, 2025  \n [https://doi.org/10.21203/rs.3.rs-8097114/v1](https://doi.org/10.21203/rs.3.rs-8097114/v1)  \n 􀁱 􀅏 This work is licensed under a Creative Commons Attribution 4.0 International License.  \nRead Full License  \n There is  con¬ ict of interest to disclose  \nThe purpose was to test the hypothesis that exposures to organochlorine compounds are associated with body weight increases in a dietary intervention study.  \nIn the DioGenes trial, adults with obesity who had at « rst lost at least 8% of their body weight then completed at least 26 weeks on a speci«c diet. Concentrations of major organochlorine compounds were assessed in plasma samples obtained at study baseline.  \nA total of 372 participants with complete data were examined for plasma concentrations of major organochlorine compounds. A doubling in total-PCB in plasma was associated with an increase in weight (in kg) at 26 weeks by 0.43 (0 .04;0 .83), independent of diet group and sex. Associations for most individual organochlorines were in the same direction, though mostly not statistically signi«cant, especially after adjustment. However, p,p ’-DDE showed opposite effects. Adjustment for exposure to per¬uorinated alkyl substances (PFASs) only minimally affected the «ndings.  \nElevated plasma concentrations of some organochlorine compounds were weakly associated with increased weight gain, although most individual associations did not reach statistical signi«cance after adjustment for PFAS exposure. However, p,p’-DDE concentrations showed a clear association with lowered body weight. Overall, the halogenated pollutants examined are likely to contribute to the obesity pandemic.  \nThe original RCT is with ClinicalT[rials.gov](rials.gov) number NCT00390637 .  \nOverweight and obesity have serious adverse impacts on public health internationally, and the prevalence is increasing toward highly worrisome levels [ 1] . Despite the major focus on lifestyle factors [ 1], substantial evidence suggests that environmental chemicals likely play a large role in the  \ndevelopment of overweight and obesity [2] . In particular, several persistent organic pollutants (POPs) may well act as obesogens and contribute to adipose tissue development [3], especially the polychlorinated biphenyls (PCBs) that exhibit endocrine disrupting properties [4] . Obesogenic properties of PCBs and related organochlorine compounds (OCs) have been documented in experimental animal studies, while some human studies have reported associations with overweight, in particular in highly exposed children [4–7] . Of note, the persistent pesticide DDT and its DDE metabolite have also been linked to obesity [7, 8] . A major concern in regard to the etiology of overweight is the possibility of confounding, especially in regard to concomitant and past exposures. Thus, obesity may be affected by exposure to other environmental toxicants, such as the per¬uorinated alkylate substances (PFASs) [9], as suggested by our previous report from the Diogenes clinically controlled study [ 10] . Experimental toxicology studies suggest impact on important functions, such as energy metabolism, glucose control, and thyroid hormone homeostasis that may result from exposures to PCBs [3] and PFASs [11] .  \nGiven the impossibility of conducting clinical trials of toxicant exposures, a feasible alternative is to examine chemical exposures in dietary interventions aimed at inducing and maintaining weight loss [12, 13] . Due to the long biological half-life of several obesogens [ 11, 14], their concentrations in serum or plasma measured at baseline are likely to remain virtually unchanged throughout the duration of a oneyear study duration. Still, weight loss may possibly result in the re","cbCaitbjgHJt0O7N","https://ap.wps.com/l/cbCaitbjgHJt0O7N","pdf",934690,18,"English","# Background\n## Obesogens and persistent organic pollutants\n## Confounding by other environmental toxicants\n# Study design and data\n## DioGenes dietary intervention trial\n## Dietary protocol and participant follow-up\n# Measurements and statistical associations\n## Baseline plasma organochlorines\n## Total-PCB and individual compound associations\n## Adjustment for PFAS exposure\n# Conclusions","[{\"question\":\"What hypothesis does the study test about organochlorine exposure and weight?\",\"answer\":\"It tests whether exposures to organochlorine compounds are associated with body weight increases during a dietary intervention study.\"},{\"question\":\"How were organochlorine compounds measured and when?\",\"answer\":\"Concentrations of major organochlorine compounds were assessed in plasma samples obtained at study baseline.\"},{\"question\":\"What key pattern did the study observe regarding PCBs and p,p’-DDE?\",\"answer\":\"A doubling in total-PCB was associated with increased weight at 26 weeks, while p,p’-DDE showed the opposite effect, linking to lower body weight.\"}]","Exposure to organochlorine compounds in relation to weight maintenance | PDF",1790740763,45]