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This research used two-sample Mendelian randomization combined with meta-analysis to evaluate associations between genetically predicted AIDs and 33 cancer types, following STROBE-MR guidance. Instrumental variables were AID-associated SNPs from FinnGen, UK Biobank, and other databases, with multiple MR approaches and sensitivity, heterogeneity, and reverse-causality checks. Eight significant results were observed across discovery and replication, providing evidence to support health management guidance for patients with AIDs.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/exploring-the-potential-link-between-autoimmune-diseases-and-pan-cancer-a-multidatabase-mendelian-randomization-analysis/370509/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/exploring-the-potential-link-between-autoimmune-diseases-and-pan-cancer-a-multidatabase-mendelian-randomization-analysis/370509.png","ImageObject",300,407,{"name":92,"@type":93},"Kyle","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What research question does the study address about autoimmune diseases and cancer?","Question",{"text":113,"@type":114},"The study investigates whether there is a causal genetic-level relationship between autoimmune diseases (AIDs) and pan-cancer risk.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which methods and data sources were used in the analysis?",{"text":118,"@type":114},"The study applied two-sample Mendelian randomization and meta-analysis, using AID-associated SNPs as instrumental variables from FinnGen, UK Biobank, and other databases, with analyses aligned to STROBE-MR guidelines.",{"name":120,"@type":111,"acceptedAnswer":121},"What major findings were reported from discovery and replication stages?",{"text":122,"@type":114},"Eight significant associations were identified in both stages, including increased risk links such as myasthenia gravis with oral cavity cancer and multiple sclerosis with chronic lymphocytic leukemia and small intestine cancer.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},370509,1790469748,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},3985741905716,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Wiley  \nJournal of Immunology Research Volume 2025, Article ID 6468979, 10 pages [https://doi.org/10.1155/jimr/6468979](https://doi.org/10.1155/jimr/6468979)  \nResearch Article  \nExploring the Potential Link Between Autoimmune Diseases and Pan-Cancer: A Multidatabase Mendelian Randomization Analysis  \nChenguang Wang, Zhiyong Liu, Yuhao Zhou, Yan He, Yashu Zhang, Shiqi Chen, Wenqing Yang, and Lijun Fan   \nCentre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University,  \nHarbin City 150081, Heilongjiang Province, China  \nCorrespondence should be addressed to Lijun Fan; [fanlijun@hrbmu.edu.cn](fanlijun@hrbmu.edu.cn)  \nReceived 7 December 2024; Accepted 29 March 2025  \nAcademic Editor: Jinyi Tang  \nCopyright © 2025 Chenguang Wang et al. Journal of Immunology Research published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \nBackground: The relationship between autoimmune diseases (AIDs) and cancer is unclear and this study aimed to investigate the relationship between AIDs and cancer at the genetic level using Mendelian randomization (MR) .  \nMethods: The study employed two-sample MR and meta-analysis to investigate the association between AIDs and 33 types of cancer, following STROBE-MR guidelines. Single nucleotide polymorphisms (SNPs) associated with AIDs were used as instrumental variables, with data from FinnGen, UK Biobank, and other databases. MR analyses included sensitivity checks, heterogeneity assessments, and reverse causality tests, using multiple MR methods (inverse-variance weighted (IVW), weighted median, MR-Egger, etc.) . Meta-analysis was performed on validated results to confirm findings, with statistical analyses conducted using R software.  \nResults: The results identified eight significant associations in both discovery and replication stages. Key findings include that myasthenia gravis (MG) significantly increases the risk of oral cavity cancer, multiple sclerosis (MS) is linked to increased risks of chronic lymphocytic leukemia (CLL) and small intestine cancer, and ulcerative colitis (UC) has mixed effects, reducing the risk of uterine cervix and larynx cancers, but increasing risks for pancreatic and bladder cancers. Meta-analysis confirmed eight secondary findings, highlighting pathogenic associations such as type 1 diabetes with esophagus cancer and protective effects like systemic lupus erythematosus (SLE) against acute myelocytic leukemia.  \nConclusions: This study provides evidence of a causal relationship between multiple AIDs and different cancer risks at the genetic level and provides a reference for the health management of patients with AIDs.  \nKeywords: AID; autoimmune disease; cancer; malignancy; UK Biobank  \n1. Introduction  \nCancer is a disease characterized by the uncontrolled growth and division of cells. The development of cancer involves genetic mutations, abnormalities in gene expression regulation, and environmental factors, though the precise causes and mechanisms are not yet fully understood. Autoimmune diseases (AIDs) represent a class of disorders where the immune system fails to maintain tolerance to self-antigens,  \nleading to attacks on the body’s own tissues and cells, resulting in chronic inflammation and organ damage [1, 2] . Common AIDs include systemic lupus erythematosus(SLE), multiple sclerosis (MS), Crohn’s disease (CD), ulcerative colitis (UC), myasthenia gravis (MG), rheumatoid arthritis (RA), and type 1 diabetes. The chronic inflammatory environment associated with AIDs may be linked to cancer development. Additionally, dysregulation of the immune system impairs immune surveillance, allowing abnormal cells to evade timely detection and  \n2 Journal of Immunology Research  \nelimination. Furthermore, certain treatments for AIDs, such as immunosuppressant","cbCaiq02IsKpJuQF","https://ap.wps.com/l/cbCaiq02IsKpJuQF","pdf",342469,"English","# Introduction\n# Methods and Materials\n## Study Design","[{\"question\":\"What research question does the study address about autoimmune diseases and cancer?\",\"answer\":\"The study investigates whether there is a causal genetic-level relationship between autoimmune diseases (AIDs) and pan-cancer risk.\"},{\"question\":\"Which methods and data sources were used in the analysis?\",\"answer\":\"The study applied two-sample Mendelian randomization and meta-analysis, using AID-associated SNPs as instrumental variables from FinnGen, UK Biobank, and other databases, with analyses aligned to STROBE-MR guidelines.\"},{\"question\":\"What major findings were reported from discovery and replication stages?\",\"answer\":\"Eight significant associations were identified in both stages, including increased risk links such as myasthenia gravis with oral cavity cancer and multiple sclerosis with chronic lymphocytic leukemia and small intestine cancer.\"}]","Exploring the Potential Link Between Autoimmune Diseases and Pan-Cancer - A Multidatabase Mendelian Randomization Analysis | PDF",1790188888,25]