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It highlights disproportionate burdens for Black and Hispanic women: higher SCC incidence in Black women and higher ADC incidence in Hispanic women, alongside persistently worse ADC survival and mortality for Black women. The analysis links outcomes to socioeconomic barriers, limited vaccination and screening access, late invasive diagnosis, and suggests culturally tailored interventions to narrow gaps in line with WHO elimination goals.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/exploring-racial-and-ethnic-disparities-in-cervical-cancers-histologic-subtypes-editorial-commentary/329930/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/exploring-racial-and-ethnic-disparities-in-cervical-cancers-histologic-subtypes-editorial-commentary/329930.png","ImageObject",300,407,{"name":92,"@type":93},"Ophelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",18,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Which data source is used to assess disparities by cervical cancer histologic subtype?","Question",{"text":113,"@type":114},"The commentary describes analyses based on data from the Surveillance, Epidemiology, and End Results (SEER) Program covering 2000 to 2018.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How do incidence patterns differ between SCC and ADC across racial and ethnic groups?",{"text":118,"@type":114},"For SCC, the corrected incidence rate is highest in Black women, followed by Hispanic and then White women. For ADC, the corrected incidence rate is highest in Hispanic women, followed by White women and then Black women.",{"name":120,"@type":111,"acceptedAnswer":121},"What factors are proposed to explain worse outcomes for Black women with ADC?",{"text":122,"@type":114},"The commentary points to socioeconomic barriers limiting vaccination and screening, advanced-stage diagnosis, difficulties accessing appropriate treatment, and discusses possible biological contributors that warrant further exploration.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},329930,1790013015,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":39,"preview_page_count":4},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","Editorial Commentary  \nExploring racial and ethnic disparities in cervical cancer’shistologic subtypes  \nAndréia Cristina de Melo^, Sofia Vidaurre Mendes^, Jessé Lopes da Silva^  \nDivision of Clinical Research and Technological Development, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil  \nCorrespondence to: Andréia Cristina de Melo, MD, PhD. Division of Clinical Research and Technological Development, Brazilian National Cancer Institute (INCA), André Cavalcanti Street, 37, 5th floor, 20231050, Rio de Janeiro, RJ, Brazil. Email: andreia.melo@inca.gov.br.  \nComment on: Cohen CM, Wentzensen N, Castle PE, et al. Racial and Ethnic Disparities in Cervical Cancer Incidence, Survival, and Mortality by Histologic Subtype. J Clin Oncol 2023;41:1059-68 .  \nKeywords: Racial; ethnic; disparity; cervical cancer  \nReceived: 15 November 2023; Accepted: 19 February 2024; Published online: 20 March 2024.  \ndoi: 10.21037/gpm-23-42  \nView this article at: [https://dx.doi.org/10.21037/gpm-23-42](https://dx.doi.org/10.21037/gpm-23-42)  \nCervical cancer, a preventable disease with human papillomavirus (HPV) vaccination, pre-invasive lesions screening and early diagnosis, continues to impact women globally, standing as the fourth most common cancer and the fourth leading cause of cancer-related fatalities among women. Alarmingly, approximately 90% of new cases and deaths in 2020 were concentrated in low- and middle-income countries (1) . Considering this, a recent study titled “Racial and Ethnic Disparities in Cervical Cancer Incidence, Survival, and Mortality by Histologic Subtype” exposes the persisting disparities among diverse racial and ethnic groups (2) .  \nThe mentioned study explored data from the Surveillance, Epidemiology, and End Results (SEER) Program, an American population database that provides information on cancer statistics, over the years 2000 to 2018, shedding light on an unsettling reality: the disparities extend beyond incidence rates. The findings revealed that cervical squamous cell carcinoma (SCC) disproportionately affects Black women, with a corrected incidence rate of 13.8 per 100,000, followed by Hispanic women at 11.8 per 100,000, and White women at 6.8 per 100,000 . This demonstratesa significant two-fold higher incidence in Black women as compared to White women.  \nDifferently, adenocarcinoma (ADC) is more commonly  \ndiagnosed in Hispanic women, with a corrected incidence rate of 3.0 per 100,000, followed by White women at 2.5 per 100,000 and Black women at 1.9 per 100,000 . Although Black women have a lower incidence rate of ADC, notable racial inequalities in ADC survival lead to the highest ADC mortality rates observed in this group compared to others. Therefore, beyond the inherent nature of the disease, factors contributing to the adverse outcomes for Black women with ADC extend further (3) .  \nResearch conducted in both developed and developing nations suggests that the increased susceptibility of Black populations to worse outcomes may be linked to various factors (4,5) . These factors encompass lower socioeconomic status, which is associated with limited access to vaccination and screening, advanced stage diagnosis, and difficulties in accessing appropriate treatments (6) . Besides, Cohen et al. (2) raised a discussion about the potential influence of specific biological factors contributing to the inferior outcomes of ADC in Black individuals, highlighting the need for further exploration in this area.  \nBlack women are diagnosed more frequently in an older age group (50–54 years) when compared to White women (45–49 years), both in the general population and in each racial group. Another remarkable finding was the observed  \n^ ORCID: Andréia Cristina de Melo, 0000-0002-1201-4333; Sofia Vidaurre Mendes, 0009-0003-9414-3685; Jessé Lopes da Silva, 0000- 0002-0790-9917.  \n© AME Publishing Company. Gynecol Pelvic Med 2024;7:9 | [https://dx.doi.org/10.21037/gpm-23-42](https://dx.doi.org/10.21037/","cbCaiuUGaTbvCETx","https://ap.wps.com/l/cbCaiuUGaTbvCETx","pdf",108408,"English","# Editorial Commentary\n## Study background and global burden\n## Disparities by histologic subtype (SCC vs ADC)\n## Age-at-diagnosis and peak incidence timing\n## Mortality and 5-year relative survival differences\n## Drivers of disparities and access barriers\n## WHO elimination strategy and progress gaps\n## Vaccination obstacles and uptake inequities","[{\"question\":\"Which data source is used to assess disparities by cervical cancer histologic subtype?\",\"answer\":\"The commentary describes analyses based on data from the Surveillance, Epidemiology, and End Results (SEER) Program covering 2000 to 2018.\"},{\"question\":\"How do incidence patterns differ between SCC and ADC across racial and ethnic groups?\",\"answer\":\"For SCC, the corrected incidence rate is highest in Black women, followed by Hispanic and then White women. For ADC, the corrected incidence rate is highest in Hispanic women, followed by White women and then Black women.\"},{\"question\":\"What factors are proposed to explain worse outcomes for Black women with ADC?\",\"answer\":\"The commentary points to socioeconomic barriers limiting vaccination and screening, advanced-stage diagnosis, difficulties accessing appropriate treatment, and discusses possible biological contributors that warrant further exploration.\"}]","Exploring racial and ethnic disparities in cervical cancer’s histologic subtypes - Editorial Commentary | PDF",1789986191]