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It discusses Orch-OR theory and the potential for quantum coherence in cardiac myocytes, electromagnetic and biophoton influences, heartbeat-evoked potentials, and resulting cortical processing. 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\nExploring quantum mechanisms in heart-brain interaction: Bridging physics, cardiology, and physiology  \nKalp-beyin etkileşiminde kuantum mekanizmalarını keşfetmek: Fizik, kardiyoloji ve fizyoloji arasında köprü kurmak  \nHakan Göçer1􀀬, Ahmet Barış Durukan2􀀬  \nInstitution where the research was done:  \nLiv Ankara Hospital, Ankara, Türkiye  \nAuthor Affiliations:  \n1Department of Cardiology, Private Edremit Korfez Hospital, Balıkesir, Türkiye 2Department of Cardiovascular Surgery, İstinye University Faculty of Medicine, İstanbul, Türkiye  \nRecent discoveries in quantum biology and neurocardiology call for a re-examination of how the heart and brain communicate . While classical models emphasize neural and neurochemical pathways, emerging evidence points toward complementary quantum and electromagnetic interactions that may operate concurrently.  \nThe Orchestrated Objective Reduction (Orch-OR) theory proposed by Hameroff and Penrose [1] posits that consciousness arises from quantum computations in neuronal microtubules . This theory, while still debated, opens the possibility that microtubules in other excitable tissues, such as cardiac myocytes, can also support quantum coherence and sub-neural information processing. These intracellular structures may be sensitive not only to biochemical inputs, but also to external electromagnetic influences .  \nIn parallel to this, electromagnetic field interactions in cardiovascular physiology are gaining attraction . A recent review has highlighted the diagnostic, therapeutic, and predictive implications of electromagnetic field exposure in cardiovascular disease . [2] Notably, the heart emits the most powerful electromagnetic field of  \nany organ in the body, capable of being detected several feet away. These fields may influence neural oscillations and cortical excitability, thereby modulating brain function .  \nMoreover, biophoton emissions, ultra-weak light generated by biological tissues, have been observed in both the nervous and cardiovascular systems . These emissions may support quantum coherence and serve as a non-classical channel of intercellular communication . [3] Although the mechanistic pathways are still under investigation, their coherence properties suggest a possible role in synchronizing distant physiological systems .  \nMore intriguingly, recent neuroimaging research has confirmed that heartbeat-evoked potentials (HEPs) produce detectable and functionally relevant cortical responses, particularly in the insular and somatosensory cortices . [4] These findings provide a direct link between cardiac signals and cortical processing, reinforcing the hypothesis that the heart is not merely a peripheral organ under central control, but an active participant in bidirectional communication .  \nTaken together, these findings imply that the interaction between the heart and brain may  \nCorresponding author: Hakan Göçer.  \nE-mail: [hgocer@gmail.com](hgocer@gmail.com)  \nDoi: 10.5606/tgkdc.dergisi.2025.28408  \nReceived: August 08, 2025  \nAccepted: September 09, 2025  \nPublished online: October 20, 2025  \nCite this article as: Göçer H, Durukan AB. Exploring quantum mechanisms in heart-brain interaction: Bridging physics, cardiology, and physiology. Turk Gogus Kalp Dama 2025;33(4):579-580 . doi: 10.5606/tgkdc . dergisi.2025.28408 .  \n©2025 All right reserved by the Turkish Society of Cardiovascular Surgery.  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes ([http://creativecommons.org/licenses/by-nc/4.0/](http://creativecommons.org/licenses/by-nc/4.0/)).  \n[https://tgkdc.dergisi.org](https://tgkdc.dergisi.org) 579  \nTurk Gogus Kalp Dama 2025;33(4):579-580  \nextend beyond","cbCaichjLOqeFsIB","https://ap.wps.com/l/cbCaichjLOqeFsIB","pdf",153184,"English","# Letter to the Editor\n## Quantum biology and Orch-OR\n## Electromagnetic field and biophoton influences\n## Heartbeat-evoked cortical responses\n## Interdisciplinary perspectives and proposals","[{\"question\":\"Why do the authors argue that heart–brain communication needs re-examination?\",\"answer\":\"They cite emerging findings from quantum biology and neurocardiology that suggest quantum and electromagnetic interactions could complement classical neural and neurochemical pathways.\"},{\"question\":\"What does the Orch-OR theory suggest for cellular structures beyond neurons?\",\"answer\":\"The letter states that Orch-OR proposes consciousness from quantum computations in neuronal microtubules, and it raises the possibility that microtubules in other excitable tissues, such as cardiac myocytes, may also support quantum coherence and sub-neural information processing.\"},{\"question\":\"What experimental evidence links heartbeat signals to cortical responses?\",\"answer\":\"Neuroimaging findings are described showing that heartbeat-evoked potentials (HEPs) produce detectable, functionally relevant cortical responses, particularly in the insular and somatosensory cortices.\"}]","Exploring quantum mechanisms in heart-brain interaction: Bridging physics, cardiology, and physiology - Letter to the Edıtor | PDF",1790712335]