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Even with advances in inhaled corticosteroids, beta-2 agonists, leukotriene receptor antagonists, and biologics, many patients remain poorly controlled or show corticosteroid resistance. Oxygen therapy during exacerbations is already a lifesaving standard, while longer-term use is being explored. Experimental and early clinical findings suggest improved oxygenation, anti-inflammatory actions, reduced oxidative stress, nitric oxide pathway modulation, immune enhancement, and potential angiogenesis, though evidence for HBOT is limited. Safety appears acceptable in small studies, but efficacy is inconclusive and risks such as barotrauma, oxygen toxicity, and transient anxiety require careful selection and standardized protocols. Larger randomized trials are needed to define HBOT’s adjunctive role.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/exploring-oxygen-therapy-as-a-supporting-treatment-for-asthma-current-insights-and-perspectives/461853/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/exploring-oxygen-therapy-as-a-supporting-treatment-for-asthma-current-insights-and-perspectives/461853.png","ImageObject",300,407,{"name":92,"@type":93},"Lucas Martin","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is asthma still a major health and socioeconomic challenge?","Question",{"text":112,"@type":113},"Asthma is a chronic inflammatory disorder affecting over 260 million people worldwide, and many patients face uncontrolled symptoms or corticosteroid resistance despite available pharmacological options.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What potential benefits of oxygen therapy in asthma are discussed?",{"text":117,"@type":113},"The document highlights possible benefits such as improved oxygenation, anti-inflammatory effects, reduced oxidative stress, modulation of nitric oxide signaling, enhanced immune responses, and promotion of angiogenesis.",{"name":119,"@type":110,"acceptedAnswer":120},"What evidence gap exists for hyperbaric oxygen therapy (HBOT) in asthma?",{"text":121,"@type":113},"Clinical evidence for HBOT in asthma remains limited; existing small-scale studies suggest safety but provide inconclusive efficacy results, requiring larger randomized controlled trials.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},461853,1791186166,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":26,"preview_page_count":4},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Review  \nExploring Oxygen Therapy as a Supporting Treatment for Asthma: Current Insights and Perspectives  \nMichał Zwoli ´nski 1,†, Adrian Hovagimyan 2,†, Jakub Ignatowicz 3, Marta Stelmasiak 4, Aneta Lewicka 5, Tomasz Szopi ´nski 6, Łukasz Szyma ´nski 7, Justyna Bie ´n-Kalinowska 1, Bałan J. Barbara 8, * and Sławomir Lewicki 1  \nAcademic Editors: Tsuyoshi Shuto and Tsukasa Okiyoneda  \nReceived: 14 October 2025  \nRevised: 10 December 2025  \nAccepted: 16 December 2025  \nPublished: 19 December 2025  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy in Warsaw, Pl. Z˙ elaznej Bramy 10, 00-136 Warsaw, Poland; [michal.zwolinski@uczelniamedyczna.com.pl](michal.zwolinski@uczelniamedyczna.com.pl) (M.Z.); [justyna.bien-kalinowska@uczelniamedyczna.com.pl](justyna.bien-kalinowska@uczelniamedyczna.com.pl) (J.B.-K.); [slawomir.lewicki@uczelniamedyczna.com.pl](slawomir.lewicki@uczelniamedyczna.com.pl) (S.L.)  \n2 University Clinical Hospital in Opole, al. Witosa 26, 45-401 Opole, Poland; [adrianhovagimyan8@gmail.com](adrianhovagimyan8@gmail.com)  \n[3](3 Faculty of Medical Sciences and Health Sciences)[ Faculty of Medical Sciences and Health Sciences](3 Faculty of Medical Sciences and Health Sciences), [Casimir Pulaski University of Radom](Casimir Pulaski University of Radom), [Chrobrego 27 St](Chrobrego 27 St)., 26-600 Radom, Poland; [panjakubignatowicz@gmail.com](panjakubignatowicz@gmail.com)  \n4 Department of Dietetics, Institute of Human Nutrition Science, Warsaw University of Life Sciences, Nowoursynowska 159c St., 02-776 Warsaw, Poland; [marta_stelmasiak@sggw.edu.pl](marta_stelmasiak@sggw.edu.pl)  \n[5](5 Military Centre of Preventive Medicine Modlin)[ Military Centre of Preventive Medicine Modlin](5 Military Centre of Preventive Medicine Modlin), [05-100 Nowy Dw](05-100 Nowy Dw)ó[r Mazowiecki](r Mazowiecki), [Poland](Poland); [anet.lewicka@gmail.com](anet.lewicka@gmail.com)  \n6 Institute of Clinical Sciences, Maria Sklodowska-Curie Medical Academy in Warsaw, Pl. Z˙ elaznej Bramy 10, 00-136 Warsaw, Poland; [tomasz@urologia.waw.pl](tomasz@urologia.waw.pl)  \n7 Department of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 05-552 Magdalenka, Poland; [l.szymanski@igbzpan.pl](l.szymanski@igbzpan.pl)  \n8 Department of Environmental Threat Prevention, Allergology and Immunology, Faculty of Health Sciences, Medical University of Warsaw, Pawi ´nskiego 3c, 02-106 Warsaw, Poland  \n* [Correspondence: barbara.balan@wum.edu.pl](Correspondence: barbara.balan@wum.edu.pl)[ ](Correspondence: barbara.balan@wum.edu.pl)† These authors contributed equally to this work.  \nAbstract  \nAsthma is a chronic inflammatory disorder of the airways affecting over 260 million people worldwide and remains a major clinical and socioeconomic challenge. Despite substantial advances in pharmacological management (including inhaled corticosteroids,β 2-agonists, leukotriene receptor antagonists, and biologic therapies), many patients continue to experience uncontrolled symptoms or corticosteroid resistance. This persistent unmet need has prompted interest in adjunctive and alternative treatment strategies. Oxygen therapy during asthma exacerbations and worsening pulmonary obstruction is a standard life-saving procedure. However, various forms of oxygen therapy are being considered for long-term treatment to reduce the number of exacerbations. Experimental and preliminary clinical data indicate that oxygen therapy may offer multiple benefits, including improved oxygenation, anti-inflammatory effects, reduced oxidative stress, modulation of nitric oxide signaling, enhanced immune responses, and promotion of angiogenesis. These mechanisms may collectively alleviate airway inflammation and improve pulmonary func","cbCaisTgpJKZLADi","https://ap.wps.com/l/cbCaisTgpJKZLADi","pdf",1518266,24,"English","# Abstract\n# 1. Introduction","[{\"question\":\"Why is asthma still a major health and socioeconomic challenge?\",\"answer\":\"Asthma is a chronic inflammatory disorder affecting over 260 million people worldwide, and many patients face uncontrolled symptoms or corticosteroid resistance despite available pharmacological options.\"},{\"question\":\"What potential benefits of oxygen therapy in asthma are discussed?\",\"answer\":\"The document highlights possible benefits such as improved oxygenation, anti-inflammatory effects, reduced oxidative stress, modulation of nitric oxide signaling, enhanced immune responses, and promotion of angiogenesis.\"},{\"question\":\"What evidence gap exists for hyperbaric oxygen therapy (HBOT) in asthma?\",\"answer\":\"Clinical evidence for HBOT in asthma remains limited; existing small-scale studies suggest safety but provide inconclusive efficacy results, requiring larger randomized controlled trials.\"}]","Exploring Oxygen Therapy as a Supporting Treatment for Asthma: Current Insights and Perspectives | PDF",1790762592]