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Using multivariable regression and threshold-resampling with cognitive correlations, results suggest eGFR (CKD-EPI 2021) is most informative, with correlation weakening below 57 mL/min/1.73 m2.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/exploring-kidney-function-thereshole-for-plasma-p-tau-217-use/468841/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/exploring-kidney-function-thereshole-for-plasma-p-tau-217-use/468841.png","ImageObject",300,407,{"name":42,"@type":43},"Putri","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-07","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why might plasma p-tau217 be less reliable in people with kidney disease?","Question",{"text":63,"@type":64},"Impaired kidney function can raise plasma p-tau217 unrelated to Alzheimer’s disease pathology, which can confound its interpretation.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was kidney function assessed in the study?",{"text":68,"@type":64},"Kidney function was evaluated using serum creatinine, estimated glomerular filtration rate (eGFR) from two CKD-EPI equations, and creatinine clearance (Cockcroft-Gault).",{"name":70,"@type":61,"acceptedAnswer":71},"What kidney function threshold was associated with weaker cognitive correlations?",{"text":72,"@type":64},"When eGFR (CKD-EPI 2021) fell below 57 mL/min/1.73 m2, the correlations between plasma p-tau217 and cognitive scores (MoCA, MMSE, and LMII) 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\nExploring kidney function thereshole for plasma p-tau 217 use  \nThanaporn Haethaisong1  \nWatayuth Luechaipanit2  \nAdipa Chongsuksantikul2  Thanakit Pongpitakmetha3, 4, 5, 6  \nPrawit Oangkhana 1  \nPoosanu Thanapornsangsuth2, 4, 5, 6  \n1Thai Red Cross Emerging Infectious Diseases Health Science Centre, King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand  \n2Thai Red Cross Emerging Infectious Diseases Health Science Centre, King Chulalongkorn Memorial Hospital, Bangkok, Thailand  \n3 Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand  \n4 Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand  \n5 Chula Neuroscience Center, King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand  \n6 Memory Clinic, King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand  \nCorrespondence  \nThanaporn Haethaisong, Thai Red Cross Emerging Infectious Diseases Health Science Centre, King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand.  \n[Email:](Email: tbumbim14@gmail.com)[ tbumbim14@gmail.com](Email: tbumbim14@gmail.com)  \nAbstract  \nBackground: Plasma tau phosphorylated at Thr217 (p-tau217) is emerging as a core biomarker for Alzheimer’s disease (AD), with high diagnostic accuracy and prognostic value. However, impaired kidney function may lead to elevated plasma p-tau217 unrelated to AD pathology, potentially limiting its utility in individuals with kidney disease. It remains unclear which kidney function parameter and threshold should be used to determine whether plasma p-tau217 reliably reflects AD pathology.  \nMethod: We analyzed data from patients evaluated at the Memory Clinic, King Chulalongkorn Memorial Hospital, and the Neurology Clinic, Neurological Institute of Thailand (2022–2024), who had confirmed AD status via florbetaben PET or CSFAβ42/p-tau. Plasma p-tau217 was modeled as a dependent variable in multivariable linear regression, incorporating AD status and kidney function. Kidney function was assessed using serum creatinine, estimated glomerular filtration rate (eGFR) from two CKD-EPI equations, and creatinine clearance (Cockcroft-Gault). The parameter with the largest effect size was selected for threshold analysis. To identify a kidney function threshold beyond which plasma p-tau217 becomes less reliable, we analyzed participants from the INDE cognitive aging cohort (NCT06375213). Participants were stratified by kidney function thresholds, and for each threshold, 10 participants were resampled with replacement 1,000 times. We calculated Spearman correlations between plasma p-tau217 and cognitive scores (MoCA, MMSE, and Wechsler Memory Scale LM) to identify the threshold at which this relationship weakens.  \nResult:Among140patientswith PET orCSF-confirmedAD, plasma concentration ofptau217 was significantly influenced by kidney function in models incorporating serum creatinine and eGFR (CKD-EPI 2021) (Table 2). Threshold analysis sampled from 294 INDE participants. When eGFR fell below57mL/min/1.73m2 , the correlation between plasma p-tau217 and MoCA, MMSE, LMII weakened (Figure 1). No clear trend was observed when classifying kidney function using serum creatinine level.  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Alzheimer’s Association. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association.  \nAlzheimer’s Dement. 2025;21(Suppl. 2):e105379.  \n[https://doi.org/10.1002/alz70856_105379](https://doi.org/10.1002/alz70856_105379)  \nwi[leyonlinelibrary.com/journal/alz](leyonlinelibrary.com/journal/alz)  \n1of4  \nBIOMARKERS  ","cbCaigyRHkGWZccy","https://ap.wps.com/l/cbCaigyRHkGWZccy","pdf",1958208,"English","# Background\n# Method\n# Result\n# Conclusion","[{\"question\":\"Why might plasma p-tau217 be less reliable in people with kidney disease?\",\"answer\":\"Impaired kidney function can raise plasma p-tau217 unrelated to Alzheimer’s disease pathology, which can confound its interpretation.\"},{\"question\":\"How was kidney function assessed in the study?\",\"answer\":\"Kidney function was evaluated using serum creatinine, estimated glomerular filtration rate (eGFR) from two CKD-EPI equations, and creatinine clearance (Cockcroft-Gault).\"},{\"question\":\"What kidney function threshold was associated with weaker cognitive correlations?\",\"answer\":\"When eGFR (CKD-EPI 2021) fell below 57 mL/min/1.73 m2, the correlations between plasma p-tau217 and cognitive scores (MoCA, MMSE, and LMII) weakened.\"}]","Exploring kidney function thereshole for plasma p-tau 217 use | PDF"]