[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-159925-105":59,"doc-detail-159925-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","exploration-of-solid-lipid-nanoparticles-loaded-films-as-a-wound-healing-drug-delivery-system-in-vitro-and-in-vivo-studies","Exploration of Solid Lipid Nanoparticles-Loaded Films as a Wound Healing Drug Delivery System - In Vitro and In Vivo Studies","","Fixing damaged tissue in diabetic wounds helps reduce limb amputation risk for millions of people worldwide. This study formulates solid lipid nanoparticles (SLNs) loaded with the low-solubility model drug neomycin sulfate (NES) using a hot-melt sonication approach. Process parameters for NES-SLN are optimized via a Box-Behnken design, yielding an optimal formulation with particle size 142.34 nm and 82.29% entrapment efficiency. The optimized NES-SLN is incorporated into films, producing 92.54% release up to 72 h, improved antimicrobial activity, accelerated scratch-test healing, and reduced short- and long-term inflammation in vivo for potential wound dressing use.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/exploration-of-solid-lipid-nanoparticles-loaded-films-as-a-wound-healing-drug-delivery-system-in-vitro-and-in-vivo-studies/159925/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/exploration-of-solid-lipid-nanoparticles-loaded-films-as-a-wound-healing-drug-delivery-system-in-vitro-and-in-vivo-studies/159925.png","ImageObject",300,407,{"name":92,"@type":93},"Noah","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-08-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",16,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What formulation approach is used to prepare the neomycin sulfate-loaded SLNs?","Question",{"text":113,"@type":114},"The study uses a hot-melt sonication method to formulate neomycin sulfate-loaded solid lipid nanoparticles (NES-SLN).","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the optimal NES-SLN formulation determined?",{"text":118,"@type":114},"Process parameters were optimized using a Box-Behnken design and a desirability approach to meet requirements for an ideal SLN formulation.",{"name":120,"@type":111,"acceptedAnswer":121},"What evidence supports the wound-healing potential of the NES-SLN-loaded films?",{"text":122,"@type":114},"In vitro results include drug release up to 72 h, desired antimicrobial activity, and scratch-test acceleration of wound healing; in vivo studies show reduced short- and long-term inflammation with the film system.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},159925,1788041596,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":130,"read_time":145,"preview_page_count":4},8796095462418,"https://ap-avatar.wpscdn.com/avatar/80000253c1241d02b47?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778826106357471780","Biomedical Materials & Devices (2026) 4:998–1014 [https://doi.org/10.1007/s44174-025-00403-4](https://doi.org/10.1007/s44174-025-00403-4)  \nExploration of Solid Lipid Nanoparticles‑Loaded Films as a Wound Healing Drug Delivery System: In Vitro and In Vivo Studies  \nVinay kumar chakravarthy Maddikunta1 · RajkumariThagele1 · Kumaraswamy Gandla2  \nReceived: 29 March 2025 / Accepted: 28 May 2025 / Published online: 17 June 2025  \n© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025  \nAbstract  \nIt is essential to fix damaged tissue in diabetic wounds to minimize the chances of the amputation of limbs in millions of diabetic people around the world.Solid lipid nanoparticles (SLNs) have gained more attention from researchers due to their high biocompatibility level and can make it easier to dissolve low-solubility drugs. The current study uses the hot-meltsonication method to formulate SLNs that are loaded with a model drug neomycin sulfate (NES), with a low-solubility profile. Optimization of process parameters in developing NES-SLN has been attempted with a Box-Behnken design. Based on the desirability approach, 384.36 mg of lipid, 176.96 mg of surfactant, and 249.54 mg of chitosan can meet the prerequisites of an ideal SLN formulation, which has a particle size (PS) of 142.34 nm and an entrapment efficiency of 82.29% . The optimized formula was further loaded to fabricate films (NES-SLN-F) and characterized for various parameters. The in vitro drug release profile showed that 92.54% of the NES was released for up to 72 h. NES-SLN-F was further shown to have desired anti-microbial activity. The in vitro scratch test shows that the formula accelerates wound healing. The in vivo studies demonstrated the effectiveness of NES-SLN-F in reducing both short-term and long-term inflammations. Hence, NES-SLN-F might be regarded as an appropriate candidate for wound dressing.  \nGraphical Abstract  \nKeywords Neomycin sulfate · Chitosan · Wound healing · Solid lipid nanoparticles · Films · Optimization  \nExtended author information available on the last page of the article  \nIntroduction  \nDiabetes mellitus is the most common metabolic disorder that causes major health-related issues worldwide. In 2011, 366 million people had diabetes; by 2030, 552 million people are expected to have it. Most people with diabetes live in low-and middle-income countries; over the next 19 years, these countries will see the most growth[1] . The World Health Organization (WHO) says that India and China have the most diabetic people globally, with more than 120 million diabetics in each country. WHO predicts that deaths caused by diabetes will rise by more than 50% in the next ten years. In 2005, diabetes and its consequences were responsible for the end of about 1.1 million people. Because of the growth of different macro-and micro-vascular complications, the number of people with diabetes who get sick and die has increased significantly. Patients with diabetes have problems with angiogenesis, neovascularization, matrix metalloproteinases (MMPs), keratinocytes, and fibroblasts, making it tougher to heal wounds. So, people with diabetes are more likely to get infections and sores, which can lead to disease[2] .  \nThe main goal of managing and healing wounds is to get the skin to heal quickly and well in terms of how it works and looks [3] . People are now more interested in formulating more wound dressings that keep the right amount of moisture around the wound[4] . This is because of the pathophysiology of different injuries[5] . Acute wounds generally heal through a process that includes stages of inflammation, migration, cell division, and remodeling, and the skin’s barrier functions return quickly. Chronic wounds don’t heal as soon as they should, owing to various complexities like diabetic, vascular, arterial, or pressuresores[6] . Because of this, chronic wounds usually needed a longer and more thorou","cbCaiaiX5Rg1nhMs","https://ap.wps.com/l/cbCaiaiX5Rg1nhMs","pdf",2364397,17,"English","# Introduction\n## Background on diabetes and impaired wound healing\n## Wound management goals and need for advanced dressings\n## Drug delivery systems and the role of nanotechnology\n## Rationale for solid lipid nanoparticles and film-based topical delivery","[{\"question\":\"What formulation approach is used to prepare the neomycin sulfate-loaded SLNs?\",\"answer\":\"The study uses a hot-melt sonication method to formulate neomycin sulfate-loaded solid lipid nanoparticles (NES-SLN).\"},{\"question\":\"How was the optimal NES-SLN formulation determined?\",\"answer\":\"Process parameters were optimized using a Box-Behnken design and a desirability approach to meet requirements for an ideal SLN formulation.\"},{\"question\":\"What evidence supports the wound-healing potential of the NES-SLN-loaded films?\",\"answer\":\"In vitro results include drug release up to 72 h, desired antimicrobial activity, and scratch-test acceleration of wound healing; in vivo studies show reduced short- and long-term inflammation with the film system.\"}]","Exploration of Solid Lipid Nanoparticles-Loaded Films as a Wound Healing Drug Delivery System - In Vitro and In Vivo Studies | PDF",43]