[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-457633-105":59,"doc-detail-457633-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","expert-consensus-on-glucocorticoids-injection-for-knee-osteoarthritis","Expert consensus on glucocorticoids injection for knee osteoarthritis","","Knee osteoarthritis (KOA) is a degenerative knee joint disorder that undermines physical function and quality of life while creating major burdens for patients, families, healthcare systems, and society. A stepwise management pathway following first-line non-pharmacological care is standard, yet glucocorticoids (GCs) injections—commonly used for rapid pain relief—have lacked unified guidance. To address this gap, a multidisciplinary Chinese expert panel formulated evidence-based recommendations, including GC selection, target population, administration timing, dosing frequency, contraindications, and a set of 22 key directives to standardize practice.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/expert-consensus-on-glucocorticoids-injection-for-knee-osteoarthritis/457633/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/expert-consensus-on-glucocorticoids-injection-for-knee-osteoarthritis/457633.png","ImageObject",300,407,{"name":92,"@type":93},"Blue Pony","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-07","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What problem does the expert consensus address for knee osteoarthritis care?","Question",{"text":112,"@type":113},"It targets inconsistent clinical use of glucocorticoids injections due to the lack of comprehensive guidelines or consensus documents specifically covering GC applications in KOA.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What are the main topics covered in the 22 recommendations?",{"text":117,"@type":113},"The recommendations cover GC selection, target population, timing of administration, dosing frequency, and contraindications to standardize evidence-based use.",{"name":119,"@type":110,"acceptedAnswer":120},"Who is the intended audience for applying these recommendations?",{"text":121,"@type":113},"The guidance applies to physicians and nurses in orthopedics, rheumatology, pain management, geriatrics, and rehabilitation departments across healthcare institutions at all levels.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},457633,1791045761,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962090760266,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Huang and Liu Journal of Orthopaedic Surgery and Research (2026) 21:25  \n[https://doi.org/10.1186/s13018-025-06363-1](https://doi.org/10.1186/s13018-025-06363-1)  \nJournal of Orthopaedic Surgery and Research  \nREVIEW Open Access  \nExpert consensus on glucocorticoids injection  for knee osteoarthritis  \nYe Huang1* and Peilai Liu2*  \nAbstract  \nKnee osteoarthritis (KOA), a degenerative disorder characterized by compromised physical function and diminished quality of life, imposes substantial burdens on patients, families, healthcare systems, and society. Stepwise therapeutic approach, initiated after first-line non-pharmacological interventions such as weight loss, exercise, and physical therapy, remains the cornerstone of KOA management, with glucocorticoids (GCs) injections widely adopted for rapid and effective pain relief. However, the absence of comprehensive guidelines or consensus documents specifically addressing GC applications has led to inconsistent clinical practices. To address this  \ngap, a multidisciplinary panel of Chinese KOA experts developed this consensus through iterative discussions, synthesizing current evidence and domestic clinical experience. The final document outlines 22 recommendations encompassing GC selection, target population, timing of administration, dosing frequency and contraindications, aiming to standardize evidence-based GC utilization in KOA care.  \nKeywords Knee osteoarthritis, Stepwise therapeutic approach, Injection, Glucocorticoids, Pain relief  \nBackground  \nKnee osteoarthritis (KOA) is a degenerative knee joint disease characterized by pain, deformity, limited mobility, and even disability [1]. In China, osteoarthritis affects approximately 132.81 million individuals [2], with KOA accounting for around 108.12 million cases [3]. The prevalence of KOA is rising due to population aging, with a notably higher incidence among women compared to men [4].  \nAccording to the stepwise therapeutic approach outlined in existing guidelines/consensus document [5, 6], the management of KOA is categorized into four phases. Within the pharmacotherapy stage, glucocorticoids  \n*Correspondence: Ye Huang [huangyesteve@aliyun.com](huangyesteve@aliyun.com)[ ](huangyesteve@aliyun.com)Peilai Liu  \n[gklpl@163.com](gklpl@163.com)  \n1Beijing Jishuitan Hospital, Capital Medical University, Beijing, China 2Qilu Hospital of Shandong University, Jinan, China  \n(GCs) serve as analgesics and can be precisely administered via minimally invasive techniques (e.g., intraarticular or periarticular injections) to achieve rapid anti-inflammatory and pain-relieving effects across pharmacotherapy [7]. However, the continuous emergence of novel GCs formulations has introduced clinical challenges, including variability in selection criteria, optimal timing, target populations, administration protocols, and contraindications [8] —areas that remain inadequately addressed by current guidelines [9]. This consensus addresses GCs injection in KOA management by providing evidence-based recommendations on GCs drugselection, target population, timing of administration, dosing frequency and contraindications. It aims to establish practical clinical guidance to maximize therapeutic efficacy while minimizing treatment delays, healthcare resource misuse, drug-induced complications, and adverse events.  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Comm","cbCaike6Lb0fXc2O","https://ap.wps.com/l/cbCaike6Lb0fXc2O","pdf",1512012,13,"English","# Background\n## Stepwise therapeutic approach for KOA\n# Consensus development\n## Target population\n## Intended users\n## Expert panel selection\n## Conflict of interest management\n## Consensus process and agreement level","[{\"question\":\"What problem does the expert consensus address for knee osteoarthritis care?\",\"answer\":\"It targets inconsistent clinical use of glucocorticoids injections due to the lack of comprehensive guidelines or consensus documents specifically covering GC applications in KOA.\"},{\"question\":\"What are the main topics covered in the 22 recommendations?\",\"answer\":\"The recommendations cover GC selection, target population, timing of administration, dosing frequency, and contraindications to standardize evidence-based use.\"},{\"question\":\"Who is the intended audience for applying these recommendations?\",\"answer\":\"The guidance applies to physicians and nurses in orthopedics, rheumatology, pain management, geriatrics, and rehabilitation departments across healthcare institutions at all levels.\"}]","Expert consensus on glucocorticoids injection for knee osteoarthritis | PDF",1790750003,33]