[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-376119-105":59,"doc-detail-376119-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","exosomes-in-inflammation-and-cancer-from-bench-to-bedside-applications","Exosomes in inflammation and cancer - from bench to bedside applications","","Exosomes are lipid bilayer nanovesicles secreted by nearly all cell types, crucial for intercellular communication through the transfer of proteins, nucleic acids, and lipids. This review consolidates exosome functions in inflammation and cancer. It details context-dependent pro- and anti-inflammatory effects, highlighting sepsis and inflammatory bowel disease. In cancer, exosomes reshape the tumor microenvironment by supporting angiogenesis, metastasis, and immune evasion, and they can also act as non-invasive biomarkers. Clinical potential is tempered by challenges in isolation standardization, scalable production, and functional heterogeneity, guiding future cargo-specific mechanistic and engineering-focused research toward personalized therapies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/exosomes-in-inflammation-and-cancer-from-bench-to-bedside-applications/376119/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/exosomes-in-inflammation-and-cancer-from-bench-to-bedside-applications/376119.png","ImageObject",300,407,{"name":92,"@type":93},"Adam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How do exosomes influence inflammation?","Question",{"text":112,"@type":113},"Exosomes show context-dependent pro- or anti-inflammatory effects. They can promote acute responses by delivering cytokines and miRNAs to immune cells, while suppressing chronic inflammation through immunoregulatory molecules.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What roles do exosomes play in cancer?",{"text":117,"@type":113},"Exosomes remodel the tumor microenvironment by facilitating angiogenesis, metastasis, and immune evasion through interactions with cancer-associated fibroblasts, tumor-associated macrophages, and extracellular matrix components.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is clinical translation of exosome-based approaches challenging?",{"text":121,"@type":113},"Clinical progress is hindered by difficulties in isolation standardization, scalable production, and understanding functional heterogeneity across exosome cargo and effects.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},376119,1790458595,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1374404737137,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Huang et al. Molecular Biomedicine (2025) 6:41 [https://doi.org/10.1186/s43556-025-00280-9](https://doi.org/10.1186/s43556-025-00280-9)  \nMolecular Biomedicine  \n REVIEW Open Access  \nExosomes in inflammation and cancer: from bench to bedside applications  \nShiyuan Huang1†, Fang Yan2†, Yi Qiu1†, Tao Liu1, Wenjin Zhang3, Yige Yang4, Rao Zhong1, Yang Yang5* and Xi Peng1*  \nAbstract  \nExosomes, lipid bilayer nanovesicles secreted by nearly all cell types, play pivotal roles in intercellular communication by transferring proteins, nucleic acids, and lipids. This review comprehensively summarizes their multiple functions in inflammation and cancer. In inflammation, exosomes exhibit context-dependent pro-or anti-inflammatory effects:  \nthey promote acute responses by delivering cytokines and miRNAs to activate immune cells, yet suppress chronic inflammation via immunoregulatory molecules. Two representative inflammatory diseases, namely sepsis and inflammatory bowel disease, were highlighted to elucidate their roles in the acute and chronic inflammatory diseases. In cancer, exosomes orchestrate tumor microenvironment (TME) remodeling by facilitating angiogenesis, metastasis, and immune evasion through interactions with cancer-associated fibroblasts, tumor-associated macrophages, and extracellular matrix components. Furthermore, exosomes can facilitate the transition from inflammation to cancer by impacting pertinent signaling pathways via their transported oncogenic and inflammatory molecules. Tumorderived exosomes also serve as non-invasive biomarkers correlating with disease progression. Clinically, exosomes demonstrate promise as therapeutic agents and drug carriers, evidenced by ongoing trials targeting inflammatory diseases and cancers. However, challenges in isolation standardization, scalable production, and understanding functional heterogeneity hinder clinical translation. Future research should prioritize elucidating cargo-specific mechanisms, optimizing engineering strategies, and advancing personalized exosome-based therapies. By bridging molecular insights with clinical applications, exosomes hold great potential in precision medicine for inflammation and oncology.  \nKeywords Exosomes, Inflammation, Cancer, Microenvironment, Clinical translation  \n†Shiyuan Huang, Fang Yan andYi Qiu are co-first authors.  \n*Correspondence:  \nYang Yang [yyang_tmmu@163.com](yyang_tmmu@163.com)[ ](yyang_tmmu@163.com)Xi Peng [pengxi@cdu.edu.cn](pengxi@cdu.edu.cn)  \n1 Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, No. 2025, Chengluo Avenue, Chengdu 610106, China  \n2 Geriatric Diseases Institute of Chengdu, Department of Geriatrics, Center for Medicine Research and Translation, Department of Critical Care Medicine, Chengdu Fifth People’s Hospital, The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China  \n3 Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic Diseases, Chongqing University Three Gorges Hospital, School of Medicine, Chongqing University, Chongqing, China  \n4 Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China  \n5 Department of Gastroenterology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons","cbCaihuyVUGceVLF","https://ap.wps.com/l/cbCaihuyVUGceVLF","pdf",2095902,32,"English","# Introduction\n# Exosomes in inflammation and cancer\n## Roles in inflammation\n## Roles in cancer and tumor microenvironment\n## Biomarkers and therapeutic applications","[{\"question\":\"How do exosomes influence inflammation?\",\"answer\":\"Exosomes show context-dependent pro- or anti-inflammatory effects. They can promote acute responses by delivering cytokines and miRNAs to immune cells, while suppressing chronic inflammation through immunoregulatory molecules.\"},{\"question\":\"What roles do exosomes play in cancer?\",\"answer\":\"Exosomes remodel the tumor microenvironment by facilitating angiogenesis, metastasis, and immune evasion through interactions with cancer-associated fibroblasts, tumor-associated macrophages, and extracellular matrix components.\"},{\"question\":\"Why is clinical translation of exosome-based approaches challenging?\",\"answer\":\"Clinical progress is hindered by difficulties in isolation standardization, scalable production, and understanding functional heterogeneity across exosome cargo and effects.\"}]","Exosomes in inflammation and cancer - from bench to bedside applications | PDF",1790217353,81]