[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31628":3,"doc-seo-31628":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31628,4810365810221,"Aurora","https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d",7,"Healthcare","Exosomes: compositions, biogenesis, and mechanisms in diabetic wound healing","Diabetic wounds show incomplete and delayed healing, creating a major global healthcare burden. Exosomes are lipid bilayer extracellular vesicles secreted by nearly all cells, carrying conserved and parent cell-associated proteins plus diverse bioactive macromolecules and small molecules that act as messengers between cells. They promote diabetic wound repair by regulating cellular functions, reducing oxidative stress, suppressing inflammation, enhancing vascular and epithelial regeneration, supporting collagen remodeling, and decreasing scarring. MSC-derived and skin-derived exosomes exemplify source-dependent therapeutic potential, with review focus on roles and mechanisms across origins.","cbCaill9zFUvoqpq","https://ap.wps.com/l/cbCaill9zFUvoqpq","pdf",5615188,1,23,"English","en","# Abstract\n# Introduction\n## Phases of wound healing and diabetes-related impairments\n## Conventional therapies and their limitations\n## Exosomes as noncellular therapeutic candidates","[{\"question\":\"What biological roles do exosomes play in diabetic wound healing?\",\"answer\":\"Exosomes act as messengers between cells and promote repair by regulating cellular functions, inhibiting oxidative stress damage, suppressing inflammatory responses, and enhancing vascular and epithelial regeneration, collagen remodeling, and scar reduction.\"},{\"question\":\"What features make exosomes suitable as therapeutic candidates?\",\"answer\":\"Exosomes are extracellular vesicles with lipid bilayer membranes that carry biologically active proteins and macromolecules, enabling functional changes in recipient cells and supporting therapeutic effects in diabetic wounds.\"},{\"question\":\"How do exosomes from different sources differ in wound healing potential?\",\"answer\":\"Exosomes from different tissues or cells may show varying therapeutic strengths. For example, MSC-derived exosomes are highlighted for stability, permeability, biocompatibility, and immunomodulatory properties, while skin-derived exosomes help modulate inflammation and support regeneration of key skin cells.\"}]",1779829265,58,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"exosomes-compositions-biogenesis-and-mechanisms-in-diabetic-wound-healing","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/healthcare/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/exosomes-compositions-biogenesis-and-mechanisms-in-diabetic-wound-healing/31628/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-05-26",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"What biological roles do exosomes play in diabetic wound healing?","Question",{"text":73,"@type":74},"Exosomes act as messengers between cells and promote repair by regulating cellular functions, inhibiting oxidative stress damage, suppressing inflammatory responses, and enhancing vascular and epithelial regeneration, collagen remodeling, and scar reduction.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"What features make exosomes suitable as therapeutic candidates?",{"text":78,"@type":74},"Exosomes are extracellular vesicles with lipid bilayer membranes that carry biologically active proteins and macromolecules, enabling functional changes in recipient cells and supporting therapeutic effects in diabetic wounds.",{"name":80,"@type":71,"acceptedAnswer":81},"How do exosomes from different sources differ in wound healing potential?",{"text":82,"@type":74},"Exosomes from different tissues or cells may show varying therapeutic strengths. For example, MSC-derived exosomes are highlighted for stability, permeability, biocompatibility, and immunomodulatory properties, while skin-derived exosomes help modulate inflammation and support regeneration of key skin cells.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]