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Tumor-cell-derived exosomes transport multiple integrins that are tightly linked to tumor progression. This review analyzes how exosomal integrins control tumor-cell proliferation, migration, and invasion, and highlights their roles in tumor initiation and development. It also evaluates exosomal integrins as drug-delivery candidates and as biomarkers to support clinical prediction, including diagnosis, prognosis assessment, and treatment-response forecasting, aiming to guide future research and clinical translation toward more precise cancer care.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/exosomal-integrins-in-tumor-progression-treatment-and-clinical-prediction-review/332768/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/exosomal-integrins-in-tumor-progression-treatment-and-clinical-prediction-review/332768.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-11","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What roles do exosomal integrins play in tumor progression?","Question",{"text":113,"@type":114},"Exosomal integrins regulate tumor-cell proliferation, migration, and invasion, and contribute to tumor initiation and progression. They also support key processes involved in cancer development.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How can exosomal integrins be used in cancer treatment?",{"text":118,"@type":114},"The review explores the potential of exosomal integrins as drug-delivery systems. It also summarizes integrin inhibitor strategies that disrupt integrin–ligand interactions.",{"name":120,"@type":111,"acceptedAnswer":121},"What clinical value do exosomal integrins have?",{"text":122,"@type":114},"Exosomal integrins are discussed as candidates for clinical tumor prediction and as biomarkers. Their applications include diagnosis, prognosis assessment, and predicting treatment response.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},332768,1790253320,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},962075114765,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","INTERNATIONAL JOURNAL OF ONCOLOGY 65: 118, 2024  \nExosomal integrins in tumor progression, treatment and clinical prediction (Review)  \nYU‑QING SHEN 1* , LEI SUN2* , SHI‑MING WANG 1 , XIAN‑YU ZHENG 1 and RUI XU 1 1College & Hospital of Stomatology, Anhui Medical University, Key Laboratory of Oral Diseases  \n2  \nResearch of Anhui Province, Hefei, Anhui 230032, P.R. China; Department of Blood Transfusion, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China  \nReceived July 23, 2024; Accepted October 17, 2024  \nDOI: 10.3892/ijo.2024.5706  \nAbstract. Integrins are a large family of cell adhesion molecules involved in tumor cell differentiation, migration, proliferation and neovascularization . Tumor cell‑derived exosomes carry a large number of integrins, which are closely associated with tumor progression. As crucial mediators of intercellular communication, exosomal integrins have gained attention in the field of cancer biology. The present review examined the regulatory mechanisms of exosomal integrins in tumor cell proliferation, migration and invasion, and empha‑ sized their notable roles in tumor initiation and progression. The potential of exosomal integrins as drug delivery systems in cancer treatment was explored. Additionally, the potential of exosomal integrins in clinical tumor prediction was consid‑ ered, while summarizing their applications in diagnosis, prognosis assessment and treatment response prediction. Thus, the present review aimed to provide guidance and insights for future basic research and the clinical translation of exosomalintegrins. The study of exosomal integrins is poised to offer new perspectives and methods for precise cancer treatment and clinical prediction.  \nContents  \n1. Introduction  \n2. Exosome biogenesis, composition and function  \n3. Structure and function of integrin and exosomal integrin  \nCorrespondence to: Dr Xian‑Yu Zheng or Professor Rui Xu, College & Hospital of Stomatology, Anhui Medical University, Key Laboratory of Oral Diseases Research of Anhui Province, 81 Meishan Road, Shushan, Hefei, Anhui 230032, P.R. China  \nE‑mail: [zhengxianyu1982@163.com](zhengxianyu1982@163.com)  \nE‑mail: [dentistxr@126.com](dentistxr@126.com)  \n*Contributed equally  \nKey words: exosome, integrin, tumor progression, treatment, biomarkers  \n4. Exosomal integrins in tumorigenesis and metastasis  \n5. Exosomal integrins in tumor drug resistance  \n6. Exosomal integrins in the treatment and diagnosis of tumors  \n7. Challenges and prospectives  \n1. Introduction  \nIntegrins are important cell surface adhesion receptors that bind to both extracellular matrix (ECM) ligands and cell surface ligands (1) . As pivotal signaling molecules, integrins mediate cell migration and adhesion (2,3) . Previous reports have shown that integrins are highly expressed in a variety of cancer types including lung cancer, hepatocellular carcinoma, pancreatic cancer and head and neck squamous cell carci‑ nomas, and serve crucial roles in nearly every stage of cancer progression, including the initiation of primary tumor forma‑ tion, subsequent growth and the metastatic cascade (4‑8) . Integrin‑mediated sensing, stiffening and remodeling of the tumor stroma are key steps in supporting tumor cell inva‑ sion, acquiring cancer stem cell (CSC) characteristics and developing drug resistance during cancer progression (9,10) . In addition, integrins have emerged as attractive targets for both predicting cancer prognosis and devising therapeutic strategies (11) . Several integrin inhibitors, which disrupt the interaction between integrins and their respective ligands, hold notable therapeutic promise (12) .  \nExosomes are extracellular vesicles (EVs) secreted by cells, which serve a crucial role in regulating intercellular transport. Specifically, exosomes influence the state of both adjacent and distant cells by delivering nucleic acids, proteins and lipids (13) . Tumor‑derived exosomes (TDEs) are partic","cbCaifA5mVDZ95wo","https://ap.wps.com/l/cbCaifA5mVDZ95wo","pdf",3413578,15,"English","# 1. Introduction\n# 2. Exosome biogenesis, composition and function\n# 3. Structure and function of integrin and exosomal integrin\n# 4. Exosomal integrins in tumorigenesis and metastasis\n# 5. Exosomal integrins in tumor drug resistance\n# 6. Exosomal integrins in the treatment and diagnosis of tumors\n# 7. Challenges and prospectives","[{\"question\":\"What roles do exosomal integrins play in tumor progression?\",\"answer\":\"Exosomal integrins regulate tumor-cell proliferation, migration, and invasion, and contribute to tumor initiation and progression. They also support key processes involved in cancer development.\"},{\"question\":\"How can exosomal integrins be used in cancer treatment?\",\"answer\":\"The review explores the potential of exosomal integrins as drug-delivery systems. It also summarizes integrin inhibitor strategies that disrupt integrin–ligand interactions.\"},{\"question\":\"What clinical value do exosomal integrins have?\",\"answer\":\"Exosomal integrins are discussed as candidates for clinical tumor prediction and as biomarkers. Their applications include diagnosis, prognosis assessment, and predicting treatment response.\"}]","Exosomal integrins in tumor progression, treatment and clinical prediction (Review) | PDF",1789999431,38]