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Liquid biopsy offers a non-invasive diagnostic strategy that supports timely treatment decisions and helps predict tumor recurrence risk. Circulating exosomes in body fluids carry tumor-derived proteins, lipids, microRNAs, and other RNAs reflecting GI tumorigenesis, progression, and treatment response. This review summarizes exosome composition, cargo-sorting pathways, clinical diagnostic evidence, and practical challenges for clinical translation.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/exosomal-biomarkers-a-novel-frontier-in-the-diagnosis-of-gastrointestinal-cancers/373182/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/exosomal-biomarkers-a-novel-frontier-in-the-diagnosis-of-gastrointestinal-cancers/373182.png","ImageObject",300,407,{"name":92,"@type":93},"Ophelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How does liquid biopsy support early diagnosis of gastrointestinal cancers?","Question",{"text":113,"@type":114},"Liquid biopsy enables non-invasive detection of premalignant GI lesions and early cancers. It also helps guide prognostic assessment related to tumor recurrence risk.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What do circulating exosomes contain that makes them useful as biomarkers?",{"text":118,"@type":114},"Exosomes in body fluids are enriched with tumor-derived proteins, lipids, microRNAs, and other RNAs. These cargo components reflect tumorigenesis, progression, and treatment response in GI cancers.",{"name":120,"@type":111,"acceptedAnswer":121},"What topics does the review cover regarding exosomes?",{"text":122,"@type":114},"The review provides an overview of exosome composition and cargo-sorting pathways. It also summarizes clinical evidence for diagnostic biomarker use and discusses challenges for diagnostic and predictive applications.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},373182,1790241324,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","| W | J | G | O | World Journal of\u003Cbr>Gastrointestinal Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Oncol 2025 April 15; 17(4): 103591  \nDOI: 10.4251/wjgo.v17.i4.103591 ISSN 1948-5204 (online)  \nREVIEW  \nExosomal biomarkers: A novel frontier in the diagnosis of gastrointestinal cancers  \nYuan Zhang, Ning-Ning Yue, Li-Yu Chen, Cheng-Mei Tian, Jun Yao, Li-Sheng Wang, Yu-Jie Liang, Dao-Ru Wei, Hua-Lin Ma, De-Feng Li  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade A, Grade A, Grade B, Grade B, Grade B Novelty: Grade A, Grade A, Grade B, Grade B, Grade B  \nCreativity or Innovation: Grade A, Grade A, Grade B, Grade B, Grade B  \nScientific Significance: Grade A, Grade A, Grade B, Grade B, Grade B  \nP-Reviewer: Gugulothu D; Xu JJ; Yuan Z  \nReceived: November 28, 2024  \nRevised: January 24, 2025  \nAccepted: February 25, 2025  \nPublished online: April 15, 2025  \nProcessing time: 118 Days and 11.3 Hours  \nYuan Zhang, Li-Yu Chen, Li-Sheng Wang, De-Feng Li, Department of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518000, Guangdong Province, China  \nYuan Zhang, Department of Medical Administration, Huizhou Institute for Occupational Health, Huizhou 516000, Guangdong Province, China  \nNing-Ning Yue, Department of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University), Shenzhen 518000, Guangdong Province, China  \nCheng-Mei Tian, Department of Emergency, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518000, Guangdong Province, China  \nJun Yao, Department of Gastroenterology, Shenzhen People’s Hospital (Jinan University of Second Clinical Medical Sciences), Shenzhen 518000, Guangdong Province, China  \nYu-Jie Liang, Department of Child and Adolescent Psychiatry, Shenzhen Kangning Hospital, Shenzhen 518000, Guangdong Province, China  \nDao-Ru Wei, Department of Rehabilitation, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518000, Guangdong Province, China  \nHua-Lin Ma, Department of Nephrology, The Second Clinical Medical College, Jinan  \nUniversity, Shenzhen 518020, Guangdong Province, China Co-first authors: Yuan Zhang and Ning-Ning Yue.  \nCo-corresponding authors: Hua-Lin Ma and De-Feng Li.  \nCorresponding author: De-Feng Li, MD, PhD, Associate Chief Physician, Department of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), No. 1017 Dongmen North Road, Luohu District, Shenzhen 518000, Guangdong Province, China.  \n[li.defeng@szhospital.com](li.defeng@szhospital.com)  \n WJGO  [https://www.wjgnet.com](https://www.wjgnet.com) 1 April 15, 2025  Volume 17  Issue 4   \nZhang Y et al. Exosomal biomarkers in GI cancer diagnosis  \nAbstract  \nGastrointestinal (GI) cancers, which predominantly manifest in the stomach, colorectum, liver, esophagus, and pancreas, accounting for approximately 35% of global cancer-related mortality. The advent of liquid biopsy has introduced a pivotal diagnostic modality for the early identification of premalignant GI lesions and incipient cancers. This non-invasive technique not only facilitates prompt therapeutic intervention, but also serves as a critical adjunct in prognosticating the likelihood of tumor recurrence. The wealth of circulating exosomes present in body fluids is often enric","cbCaiqZpitS85lBK","https://ap.wps.com/l/cbCaiqZpitS85lBK","pdf",18975896,26,"English","# Exosomal biomarkers in GI cancer diagnosis\n## Liquid biopsy and GI cancer early detection\n## Exosome composition, cargo sorting, and biomarker rationale\n## Clinical evidence for diagnostic use\n## Challenges and prospects for clinical application","[{\"question\":\"How does liquid biopsy support early diagnosis of gastrointestinal cancers?\",\"answer\":\"Liquid biopsy enables non-invasive detection of premalignant GI lesions and early cancers. It also helps guide prognostic assessment related to tumor recurrence risk.\"},{\"question\":\"What do circulating exosomes contain that makes them useful as biomarkers?\",\"answer\":\"Exosomes in body fluids are enriched with tumor-derived proteins, lipids, microRNAs, and other RNAs. These cargo components reflect tumorigenesis, progression, and treatment response in GI cancers.\"},{\"question\":\"What topics does the review cover regarding exosomes?\",\"answer\":\"The review provides an overview of exosome composition and cargo-sorting pathways. It also summarizes clinical evidence for diagnostic biomarker use and discusses challenges for diagnostic and predictive applications.\"}]","Exosomal biomarkers: A novel frontier in the diagnosis of gastrointestinal cancers | PDF",1790197527,66]