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The review identifies disparities in treatment access and implementation and links them to patient-level factors such as race, socioeconomic status, gender, and geography, as well as challenges in germline genetics and tumor genomics evaluation. It further analyzes differences in applying palliative and end-of-life care and discusses opportunities for intervention, ongoing barriers to change, and national or international society recommendations to reduce disparities.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/existing-health-inequities-in-the-treatment-of-advanced-and-metastatic-cancers-review/340626/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/existing-health-inequities-in-the-treatment-of-advanced-and-metastatic-cancers-review/340626.png","ImageObject",300,407,{"name":92,"@type":93},"Genevieve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the purpose of this review?","Question",{"text":112,"@type":113},"To identify health inequities related to medical treatment and supportive care for patients with advanced/metastatic cancer and recommend solutions to promote health equity.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which factors contribute to disparities in treatment access and implementation?",{"text":117,"@type":113},"Disparities are associated with race, socioeconomic status, gender, and geography, and they also affect evaluation processes and quality of palliative and end-of-life care.",{"name":119,"@type":110,"acceptedAnswer":120},"How do precision medicine testing disparities affect care?",{"text":121,"@type":113},"The review notes that germline and tumor testing utilization is not universal or equitable across tumor types and across groups defined by race/ethnicity, age, geography, and socioeconomic status, which can limit personalized treatment.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},340626,1790130061,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Current Oncology Reports (2024) 26:1553–1562 [https://doi.org/10.1007/s1](https://doi.org/10.1007/s1) 1912-024-01617-3  \nREVIEW  \nExisting Health Inequities in the Treatment of Advanced and Metastatic Cancers  \nNavya Nair1,2 · Matthew Schlumbrecht1,2  \nAccepted: 14 October 2024 / Published online: 4 November 2024 © The Author(s) 2024  \nAbstract  \nPurpose of Review This study aims to identify health inequities related to the medical treatment and supportive care of patients with advanced/metastatic cancer and recommend solutions to promote health equity.  \nRecent findings Despite robust strides in the development of therapeutic strategies for advanced and metastatic cancer, significant disparities in treatment access and implementation exist. Race, socioeconomic status, gender, and geography represent just a few of the individual-level factors which contribute to challenges in treatment administration, thorough evaluation of germline genetics and tumor genomics, and quality palliative and end-of-life care.  \nSummary Given the increasing complexity of cancer treatments and our enhanced understanding of tumor biology, efforts to uniformly provide equitable and high-level care to all patients are needed. In this review we will discuss factors that contribute to health inequities in patients with advanced and metastatic cancer diagnoses, highlighting opportunities for intervention, ongoing challenges in change implementation, and national and international society recommendations to eliminate disparities. Acknowledging existing inequities and engaging in multilevel discourse with key stakeholders is needed to optimize care practices to the benefit of all patients.  \nKeywords Cancer · Metastatic · Health inequity · Disparities · Race  \nIntroduction  \nDespite robust strides in the development of novel therapeutics for advanced and metastatic cancer, significant disparities in treatment access and implementation exist. The recognition of these disparities has improved significantly over the recent decades, and in a number of contexts, including screening, incidence, prevalence, stage, mortality, survival, morbidity, survivorship, and financial burden of the disease [1] . Description of these health inequities, however, has not translated into substantial systematic changes to eliminate them. Race remains a major contributor to  \n􀀍 Matthew Schlumbrecht [mschlumbrecht@miami.edu](mschlumbrecht@miami.edu)  \n1 Division of Gynecologic Oncology, Sylvester Comprehensive Cancer Center, 1121 NW 14th St, Suite 345C, Miami, FL 33136, USA  \n2 Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Miami Miller School of Medicine, Miami, FL, USA  \nhealth disparities. Black people are more likely than White people to die from cancer despite the increasing availability of effective treatments and declining national trends in cancer mortality, with marked disparities apparent specifically in malignances of the prostate, stomach, and uterus [2]. Native Americans with liver, stomach, and kidney cancers have worse survival compared to White people [3], and Hispanics are disproportionately affected by cancers of the uterine cervix [4] . Numerous factors contribute to an individual’s prognosis after a cancer diagnosis, including germline genetics, tumor biology, environment, behavior, healthcare access and delivery, and social determinants of health [1] . Transparent acknowledgement and discourse of current disparities is a first step in initiating steps to eliminate them across a number of domains. In this review, we will identify health inequities as they relate the evaluation and medical treatment of patients with advanced/metastatic cancer, examine differences in the application of palliative and supportive care interventions, and suggest solutions to promote health equity.  \nHealth Disparities in Precision Medicine Testing  \nIn the age of precision medicine, increasing emphasis is placed on understanding tumor biology to make ed","cbCaithD8N3EioBM","https://ap.wps.com/l/cbCaithD8N3EioBM","pdf",753145,"English","# Abstract\n# Introduction\n# Health Disparities in Precision Medicine Testing\n## Germline Genetic Testing\n## Somatic Tumor Testing","[{\"question\":\"What is the purpose of this review?\",\"answer\":\"To identify health inequities related to medical treatment and supportive care for patients with advanced/metastatic cancer and recommend solutions to promote health equity.\"},{\"question\":\"Which factors contribute to disparities in treatment access and implementation?\",\"answer\":\"Disparities are associated with race, socioeconomic status, gender, and geography, and they also affect evaluation processes and quality of palliative and end-of-life care.\"},{\"question\":\"How do precision medicine testing disparities affect care?\",\"answer\":\"The review notes that germline and tumor testing utilization is not universal or equitable across tumor types and across groups defined by race/ethnicity, age, geography, and socioeconomic status, which can limit personalized treatment.\"}]","Existing Health Inequities in the Treatment of Advanced and Metastatic Cancers - Review | PDF",1790037752,25]