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This study used a murine breast cancer model to compare control and voluntary running for 21 days, followed by RNA sequencing, bioinformatics, pan-cancer analysis, and cell experiments. Exercise reduced tumor size and weight, downregulated CD300E at the mRNA level, and altered key pathways including MicroRNAs and calcium signaling. Across cancers, CD300E showed expression variability and upregulation linked to worse prognosis, with roles in proliferation and apoptosis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/exercisedownregulated-cd300e-acted-as-a-negative-prognostic-implication-and-tumor-promoted-role-in-pan-cancer/331173/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/exercisedownregulated-cd300e-acted-as-a-negative-prognostic-implication-and-tumor-promoted-role-in-pan-cancer/331173.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How did exercise affect tumor growth in the breast cancer model?","Question",{"text":112,"@type":113},"Voluntary running for 21 days significantly reduced tumor size and weight without notable changes in body weight, indicating that physical activity modulated tumor dynamics.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What molecular change was observed after exercise?",{"text":117,"@type":113},"Post-exercise mRNA sequencing revealed substantial downregulation of CD300E in the exercise group and changes in pathways including MicroRNAs in cancers and the calcium signaling pathway.",{"name":119,"@type":110,"acceptedAnswer":120},"What is CD300E’s role across multiple cancer types and outcomes?",{"text":121,"@type":113},"CD300E showed significant expression variability across cancer types, with pronounced upregulation in myeloma, ovarian, lung, and colorectal cancers, and this upregulation correlated with poorer prognostic outcomes. CD300E was also associated with cancer cell proliferation and apoptosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331173,1790764303,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","TYPE Original Research PUBLISHED 31 July 2024  \nDOI 10.3389/fimmu.2024.1437068  \nOPEN ACCESS  \nEDITED BY Wenyi Jin,  \nUniversity of Hong Kong, Hong Kong SAR, China  \nREVIEWED BY Hang Song,  \nAnhui University of Chinese Medicine, China Jianzhou Cui,  \nNational University of Singapore, Singapore Zhijie Xu,  \nCentral South University, China  \n*CORRESPONDENCE Shiyi Chen  \n [shiyichen_huashan@163.com](shiyichen_huashan@163.com)[ ](shiyichen_huashan@163.com)Shuo Chen  \n [drchenshuo@136.com](drchenshuo@136.com)[ ](drchenshuo@136.com)Qing Wang  \n [Doctorwq1983@163.com](Doctorwq1983@163.com)  \n†These authors have contributed equally to this work and share the first authorship  \nRECEIVED 23 May 2024  \nACCEPTED 12 July 2024  \nPUBLISHED 31 July 2024  \nCITATION  \nLuo Z, Zhu J, Xu R, Wan R, He Y, Chen Y, Wang Q, Chen S and Chen S (2024) Exercisedownregulated CD300E acted as a negative prognostic implication and tumor-promoted role in pan-cancer.  \nFront. Immunol. 15:1437068 .  \ndoi: 10.3389/fimmu.2024.1437068  \nCOPYRIGHT  \n© 2024 Luo, Zhu, Xu, Wan, He, Chen, Wang, Chen and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nExercise-downregulated CD300E acted as a negative prognostic implication and tumor-promoted role in pan-cancer  \nZhiwen Luo 1†, Jinguo Zhu 2†, Rui Xu 3†, Renwen Wan 1, Yanwei He 1, Yisheng Chen 1, Qing Wang 4*,  \nShuo Chen 5* and Shiyi Chen 1*  \n1 Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China, 2 Department of Orthopaedics, Nantong Tongzhou Hospital of Traditional Chinese Medicine, Tongzhou, Jiangsu, China, 3The First Clinical Medicine College, Nanjing Medical University, Nanjing, China,  \n4 Department of Orthopaedics, Kunshan Hospital of Chinese Medicine, Kunshan, Jiangsu, China,  \n5 Department of Sports Medicine, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China  \nBackground: Breast cancer ranks as one of the most prevalent malignancies among women globally, with increasing incidence rates. Physical activity, particularly exercise, has emerged as a potentially significant modifier of cancer prognosis, influencing tumor biology and patient outcomes.  \nMethods: Using a murine breast cancer model, we established a control and an exercise group, where the latter was subjected to 21 days of voluntary running. RNA Sequencing, bioinformatics analysis, pan-cancer analysis, and cell experiments were performed to validate the underlying mechanisms.  \nResults: We observed that exercise significantly reduced tumor size and weight, without notable changes in body weight, suggesting that physical activity can modulate tumor dynamics. mRNA sequencing post-exercise revealed substantial downregulation of CD300E in the exercise group, accompanied by alterations in critical pathways such as MicroRNAs in cancers and the Calcium signaling pathway. Expanding our analysis to a broader cancer spectrum, CD300E demonstrated significant expression variability across multiple cancer types, with pronounced upregulation in myeloma, ovarian, lung, and colorectal cancers. This upregulation was correlated with poorer prognostic outcomes, emphasizing CD300E ’s potential role as a prognostic marker and therapeutic target. Moreover, CD300E expression was associated with cancer cell proliferation and apoptosis.  \nConclusion: The study highlights the dual role of exercise in modulating gene expression relevant to tumor growth and the potential of CD300E as a target in cancer therapeutics. Further research is encouraged to explore the mechanisms by which exercise and CD300E i","cbCaimX2P5SZ4sI2","https://ap.wps.com/l/cbCaimX2P5SZ4sI2","pdf",9530370,16,"English","# 1 Introduction\n# 2 Methods\n# 3 Results\n# 4 Conclusion","[{\"question\":\"How did exercise affect tumor growth in the breast cancer model?\",\"answer\":\"Voluntary running for 21 days significantly reduced tumor size and weight without notable changes in body weight, indicating that physical activity modulated tumor dynamics.\"},{\"question\":\"What molecular change was observed after exercise?\",\"answer\":\"Post-exercise mRNA sequencing revealed substantial downregulation of CD300E in the exercise group and changes in pathways including MicroRNAs in cancers and the calcium signaling pathway.\"},{\"question\":\"What is CD300E’s role across multiple cancer types and outcomes?\",\"answer\":\"CD300E showed significant expression variability across cancer types, with pronounced upregulation in myeloma, ovarian, lung, and colorectal cancers, and this upregulation correlated with poorer prognostic outcomes. CD300E was also associated with cancer cell proliferation and apoptosis.\"}]","Exercisedownregulated CD300E acted as a negative prognostic implication and tumor-promoted role in pan-cancer | PDF",1789992025]