[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-383026-105":59,"doc-detail-383026-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","exercise-training-reduces-the-inflammatory-response-and-promotes-intestinal-mucosa-associated-immunity-in-lynch-syndrome","Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-Associated Immunity in Lynch Syndrome","","Lynch syndrome (LS) is a hereditary condition associated with high lifetime colorectal and endometrial cancer risk, and exercise is a non-pharmacologic approach with unclear prospective immune biology effects in LS carriers. A 12-month aerobic cycling intervention enrolled 21 LS patients in a non-randomized sequential clinical trial. The study assessed cardiorespiratory fitness and circulating and colorectal tissue biomarkers using metabolomics, bulk mRNA sequencing, and spatial transcriptomics. Results showed increased VO2peak and reduced inflammatory markers, alongside elevated colonic NK and CD8+ T cells confirmed by spatial transcriptomics and IHC, with implications for cancer interception.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/exercise-training-reduces-the-inflammatory-response-and-promotes-intestinal-mucosa-associated-immunity-in-lynch-syndrome/383026/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/exercise-training-reduces-the-inflammatory-response-and-promotes-intestinal-mucosa-associated-immunity-in-lynch-syndrome/383026.png","ImageObject",300,407,{"name":92,"@type":93},"Jasmine","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the purpose of the 12-month exercise intervention in Lynch syndrome carriers?","Question",{"text":113,"@type":114},"To evaluate how a 12-month aerobic cycling program affects immune system biology in patients with Lynch syndrome and potentially influences cancer risk pathways.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the exercise program structured and compared to control?",{"text":118,"@type":114},"Participants completed cycling classes three times weekly for 45 minutes, compared with usual care plus a one-time exercise counseling session as the control.",{"name":120,"@type":111,"acceptedAnswer":121},"Which immune and inflammatory outcomes changed after the exercise intervention?",{"text":122,"@type":114},"The intervention increased oxygen consumption (VO2peak) and decreased inflammatory markers such as prostaglandin E, with increased colonic NK and CD8+ T cell levels shown by spatial transcriptomics and confirmed by IHC.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},383026,1790491981,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":41},2336478487870,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-Associated Immunity in Lynch Syndrome  \nNan Deng1, Laura Reyes-Uribe1, Johannes F. Fahrmann1, Whittney S. Thoman1, Mark F. Munsell2, Jennifer B. Dennison1, Eunice Murage1, Ranran Wu1, Ernest T. Hawk1, Selvi Thirumurthi3,4,  \nPatrick M. Lynch3,4, Christina M. Dieli-Conwright5,6, Alexander J. Lazar7,8, Sonali Jindal9, Khoi Chu9, Manoj Chelvanambi10, Karen Basen-Engquist11, Yisheng Li2, Jennifer A. Wargo8,10,  \nFlorencia McAllister1,4,12,13, James P. Allison9,12, Padmanee Sharma9,12,14, Krishna M. Sinha1, Samir Hanash1, Susan C. Gilchrist1,15, and Eduardo Vilar1,4,13  \nABSTRACT  \n◥  \nPurpose: Lynch syndrome (LS) is a hereditary condition with a high lifetime risk of colorectal and endometrial cancers. Exercise is a non-pharmacologic intervention to reduce cancer risk, though its impact on patients with LS has not been prospectively studied. Here, we evaluated the impact of a 12-month aerobic exercise cycling intervention in the biology of the immune system in LS carriers.  \nPatients and Methods: To address this, we enrolled 21 patients with LS onto a non-randomized, sequential intervention assignation, clinical trial to assess the effect ofa12-month exercise program that included cycling classes 3 times weekly for 45 minutes versus usual care with a one-time exercise counseling session as control. We analyzed the effects of exercise on cardiorespiratory fitness, circulating, and colorectal-tissue biomarkers using metabolomics,  \ngene expression by bulk mRNA sequencing, and spatial transcriptomics by NanoString GeoMx.  \nResults: We observed a significant increase in oxygen consumption (VO2peak) as a primary outcome of the exercise and a decrease in inflammatory markers (prostaglandin E) in colon and blood asthe secondary outcomes in the exercise versus usual care group. Gene expression profiling and spatial transcriptomics on available colon biopsies revealed an increase in the colonic mucosa levels of natural killer and CD8þ T cells in the exercise group that were further confirmed by IHC studies.  \nConclusions: Together these data have important implications for cancer interception in LS, and document for the first-time biological effects of exercise in the immune system of a target organ in patients at-risk for cancer.  \nIntroduction  \nLynch syndrome (LS) is the most common hereditary cancer syndrome, potentially affecting 1.1 million individuals in the United States (1) . LS carriers have up to 60% lifetime risk of colorectal cancer (2) . Exercise is one potential non-pharmacologic strategy to mitigate excessive colorectal cancer risk in patients with LS. In fact, exercise is associated with reduction in colorectal cancer among the general population(3)with evidence to suggest a robust risk reduction, increased functional capacity and quality of life among individuals who sustain moderate to high levels of activity over time compared with those remaining inactive (4, 5) . A similar beneficial association  \n1Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas. 2 Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas. 3 Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson, Houston, Texas. 4Clinical Cancer Genetics Program, The University of Texas MD Anderson Cancer Center, Houston, Texas. 5 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. 6 Department of Medicine, Harvard Medical School, Boston, Massachusetts. 7 Department of Behavioral Science, The University of Texas MD Anderson, Houston, Texas. 8 Department of Genomic Medicine, The University of Texas MD Anderson, Houston, Texas. 9The Immunotherapy Platform, The University of Texas MD Anderson, Houston, Texas. 10 Department of Surgical Oncology, The University of Texas MD Anderson, Houston, Texas. 11 Department of Behavioral Science","cbCaitduANkVejs2","https://ap.wps.com/l/cbCaitduANkVejs2","pdf",16515059,12,"English","# Abstract\n## Purpose\n## Patients and Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What was the purpose of the 12-month exercise intervention in Lynch syndrome carriers?\",\"answer\":\"To evaluate how a 12-month aerobic cycling program affects immune system biology in patients with Lynch syndrome and potentially influences cancer risk pathways.\"},{\"question\":\"How was the exercise program structured and compared to control?\",\"answer\":\"Participants completed cycling classes three times weekly for 45 minutes, compared with usual care plus a one-time exercise counseling session as the control.\"},{\"question\":\"Which immune and inflammatory outcomes changed after the exercise intervention?\",\"answer\":\"The intervention increased oxygen consumption (VO2peak) and decreased inflammatory markers such as prostaglandin E, with increased colonic NK and CD8+ T cell levels shown by spatial transcriptomics and confirmed by IHC.\"}]","Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-Associated Immunity in Lynch Syndrome | PDF",1790253815]