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It also outlines precision strategies using aging biomarkers, risk assessment, safety management, multidisciplinary care, and digital monitoring to guide individualized intervention and future clinical 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Bartlett,  \nUniversity of Surrey, United Kingdom  \nREVIEWED BY  \nDonald Lamkin,  \nUniversity of California, Los Angeles, United States  \nTianqi Wang,  \nNational University of Singapore, Singapore  \n*CORRESPONDENCE  \nXinming Ye  \n [tyxm@ecust.edu.cn](tyxm@ecust.edu.cn)  \n†These authors have contributed equally to this work  \nRECEIVED 10 January 2026  \nREVISED 16 July 2026  \nACCEPTED 30 July 2026  \nPUBLISHED 18 August 2026  \nCITATION  \nFang W, Wang Y, Yang Z, Zheng H, Wu Y, Chen R, Wang R, Tang H, Tang M and Ye X (2026)  \nExercise interventions remodel the aging microenvironment to improve prognosis in older patients with cancer. Front. Immunol. 17:1785073 .  \ndoi: 10.3389/fimmu.2026.1785073  \nCOPYRIGHT  \n© 2026 Fang, Wang, Yang, Zheng, Wu, Chen, Wang, Tang, Tang and Ye. This isan open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nExercise interventions remodel the aging microenvironment to improve prognosis in older patients with cancer  \nWen Fang 1†, Yihan Wang 1†, Zhenyu Yang 1, Hongyun Zheng 1, Yang Wu 1, Ruogu Chen 2, Ruilong Wang 1, Huayu Tang 3, Menghao Tang 3 and Xinming Ye 1*  \n1School of Sports Science and Engineering, East China University of Science and Technology, Shanghai, China, 2Animal Medicine, College of Life Sciences, Longyan University, Longyan, China, 3School of Pharmacy, East China University of Science and Technology, Shanghai, China  \nCancer in older adults has become a significant public health challenge, with increasing incidence and limited efficacy of conventional treatments due to aging-related biological changes, such as chronic inflammation, immune decline, metabolic dysfunction, and cellular senescence. These alterations create a protumor environment, weakening antitumor capacity and reducing treatment sensitivity. Exercise medicine has emerged as a promising systemic intervention, regulating multiple physiological systems, including metabolism, immunity, skeletal muscle, and inflammation. Through these effects, exercise reshapes the aging-driven tumor-susceptible environment, potentially improving treatment tolerability and clinical outcomes. This review explores how exercise alleviates aging-associated phenotypes like metabolic decline, chronic inflammation, immune dysfunction, and sarcopenia, enhancing tumor suppression and boosting the efficacy of chemotherapy, radiotherapy, and immunotherapy. It also discusses strategies for precision exercise interventions, such as individualized prescriptions based on aging biomarkers, comprehensive risk assessments, safety management, multidisciplinary collaboration, and digital monitoring technologies. This review highlights the importance of integrating exercise into geriatric oncology care and outlines future research directions to improve the clinical management of cancer in older adults.  \nKEYWORDS  \naging microenvironment, exercise intervention, geriatric cancer, immunosenescence, inflammaging, sarcopenia  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \nFang et al. 10.3389/fimmu.2026.1785073  \nGRAPHICAL ABSTRACT  \nExercise interventions help reshape the aging microenvironment to improve the prognosis of tumors in elderly cancer patients by addressing core aging-related challenges such as metabolic decline, inflammatory aging, immunosenescence, and sarcopenia. Regular physical activity combats metabolic dysfunction, alleviates chronic inflammation, rejuvenates immune function, and reverses sarcopenia, creating a more favorable internal environment for ca","cbCaiuLWCf6B6j1g","https://ap.wps.com/l/cbCaiuLWCf6B6j1g","pdf",2854058,"English","# Introduction\n## Rising burden of cancer in older adults and increasing treatment challenges\n# Exercise as a systemic intervention for aging-related tumor susceptibility\n## Effects on metabolism, immunity, skeletal muscle, and inflammation\n# Precision exercise interventions\n## Individualized prescriptions based on aging biomarkers\n## Risk assessment, safety management, multidisciplinary collaboration, and digital monitoring\n# Clinical integration and future research directions","[{\"question\":\"Why is cancer prognosis worse in older adults?\",\"answer\":\"Aging-related changes such as chronic inflammation, immune decline, metabolic dysfunction, and cellular senescence foster a tumor-promoting environment, reducing antitumor capacity and treatment sensitivity.\"},{\"question\":\"How can exercise improve outcomes for older patients with cancer?\",\"answer\":\"Exercise reshapes aging-driven tumor susceptibility by improving metabolic function, alleviating chronic inflammation, supporting immune function, and countering sarcopenia, which may enhance responsiveness to chemotherapy, radiotherapy, and immunotherapy.\"},{\"question\":\"What are precision exercise intervention strategies mentioned in the review?\",\"answer\":\"The review discusses individualized exercise prescriptions based on aging biomarkers, comprehensive risk assessments, safety management, multidisciplinary collaboration, and digital monitoring technologies.\"}]","Exercise interventions remodel the aging microenvironment to improve prognosis in older patients with cancer | PDF",1790132493]