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Using a murine breast cancer model with 21 days of voluntary running, the study applied RNA sequencing, bioinformatics and pan-cancer analyses alongside cellular experiments. Exercise reduced tumor size and weight and increased THSD7B expression, with pathway alterations including microRNAs and calcium signaling. Across cancers, THSD7B varied in expression, was downregulated in multiple tumors, associated with favorable prognosis, and inversely correlated with breast cancer cell proliferation, migration, and invasion.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/exercise-augmented-thsd7b-exhibited-a-positive-prognostic-implication-and-tumor-suppressed-functionality-in-pan-cancer/328588/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/exercise-augmented-thsd7b-exhibited-a-positive-prognostic-implication-and-tumor-suppressed-functionality-in-pan-cancer/328588.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How was the exercise intervention implemented in the study?","Question",{"text":112,"@type":113},"Mice were divided into a control group and an exercise group. The exercise group performed 21 days of voluntary running.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What were the main effects of exercise on tumor outcomes?",{"text":117,"@type":113},"Exercise significantly reduced tumor size and tumor weight.",{"name":119,"@type":110,"acceptedAnswer":120},"How does THSD7B relate to prognosis and breast cancer cell behavior?",{"text":121,"@type":113},"Post-exercise analysis showed notable upregulation of THSD7B. Across cancers, THSD7B expression variability included downregulation in several cancers associated with positive prognostic outcomes, and THSD7B was negatively associated with breast cancer cell proliferation, migration, and invasion.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328588,1790093858,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","TYPE Original Research PUBLISHED 05 August 2024  \nDOI 10.3389/fimmu.2024.1440226  \nOPEN ACCESS  \nEDITED BY  \nNoha Mousaad Elemam,  \nUniversity of Sharjah, United Arab Emirates  \nREVIEWED BY Luo Qiang,  \nChildren ’s Hospital of Chongqing Medical University, China  \nShuai Shao,  \nSanofi Genzyme, United States  \n*CORRESPONDENCE Shiyi Chen  \n [shiyichen_huashan@163.com](shiyichen_huashan@163.com)[ ](shiyichen_huashan@163.com)Qizhi Liu  \n [10392690@qq.com](10392690@qq.com)[ ](10392690@qq.com)Qing Wang  \n [Doctorwq1983@163.com](Doctorwq1983@163.com)  \n†These authors have contributed equally to this work and share first authorship  \nRECEIVED 29 May 2024  \nACCEPTED 22 July 2024  \nPUBLISHED 05 August 2024  \nCITATION  \nLuo Z, Zhu J, Fang Z, Xu R, Wan R, He Y, Chen Y, Chen S, Wang Q, Liu Q and Chen S (2024) Exercise-augmented THSD7B  \nexhibited a positive prognostic implication and tumor-suppressed functionality in pan-cancer.  \nFront. Immunol. 15:1440226 .  \ndoi: 10.3389/fimmu.2024.1440226  \nCOPYRIGHT  \n© 2024 Luo, Zhu, Fang, Xu, Wan, He, Chen, Chen, Wang, Liu and Chen. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nExercise-augmented THSD7B exhibited a positive prognostic implication and tumor-suppressed functionality in pan-cancer  \nZhiwen Luo 1†, Jinguo Zhu 2†, Zhengyuan Fang 3†, Rui Xu 4, Renwen Wan 1, Yanwei He 1, Yisheng Chen 1, Shuo Chen 5, Qing Wang6*, Qizhi Liu 5* and Shiyi Chen 1*  \n1 Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China, 2 Department of Orthopaedics, Nantong Tongzhou Hospital of Traditional Chinese Medicine, Tongzhou, Jiangsu, China, 3The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian, Liaoning, China, 4The First Clinical Medicine College, Nanjing Medical University,  \nNanjing, China, 5 Internal Medicine of Chinese Medicine, Nanjing Hospital of Chinese Medicine affiliated to Nanjing University of Chinese Medicine, Nanjing, China, 6 Department of Orthopaedics, Kunshan Hospital of Chinese Medicine, Kunshan, Jiangsu, China  \nBackground: Breast cancer, one of the most prevalent malignancies among women worldwide, has rising incidence rates. Physical activity, particularly exercise, has emerged as a sign ificant modifier of cancer prognosis, influencing both tumor biology and patient outcomes.  \nMethods: In this study, we utilized a murine breast cancer model, dividing mice into a control group and an exercise group; the latter underwent 21 days of voluntary running. We conducted RNA sequencing, bioinformatics analysis, pancancer analysis, and cellular experiments to investigate the underlying mechanisms influenced by exercise.  \nResults: Exercise led to a significant reduction in tumor size and weight. Postexercise mRNA sequencing indicated a notable upregulation of THSD7B in the exercised mice, with significant alterations observed in pathways such as MicroRNAs in cancers and the Calcium signaling pathway. In a broader cancer context, THSD7B showed considerable expression variability, being significantly downregulated in several cancers, correlating with positive prognostic outcomesin PRAD, LAML, KIRC, and GBM and highlighting its potential role as a prognostic marker and therapeutic target. THSD7B expression was also negatively associated with processes of breast cancer cell proliferation, migration, and invasion.  \nConclusion: This study underscores the dual role of exercise in modulating gene expression relevant to tumor growth and highlights the potential of THSD7B as a  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \ntherapeutic targe","cbCaivmU4glh4YdZ","https://ap.wps.com/l/cbCaivmU4glh4YdZ","pdf",9789057,16,"English","# Background\n## Breast cancer burden and rationale for exercise\n# Methods\n## Murine model and exercise regimen\n## RNA sequencing and pan-cancer bioinformatics\n## Cellular experiments\n# Results\n## Tumor suppression after exercise\n## THSD7B induction and pathway changes\n## Pan-cancer prognostic associations\n## Inverse links with proliferation, migration, invasion\n# Conclusion\n## THSD7B as a therapeutic target and marker\n## Future directions","[{\"question\":\"How was the exercise intervention implemented in the study?\",\"answer\":\"Mice were divided into a control group and an exercise group. The exercise group performed 21 days of voluntary running.\"},{\"question\":\"What were the main effects of exercise on tumor outcomes?\",\"answer\":\"Exercise significantly reduced tumor size and tumor weight.\"},{\"question\":\"How does THSD7B relate to prognosis and breast cancer cell behavior?\",\"answer\":\"Post-exercise analysis showed notable upregulation of THSD7B. Across cancers, THSD7B expression variability included downregulation in several cancers associated with positive prognostic outcomes, and THSD7B was negatively associated with breast cancer cell proliferation, migration, and invasion.\"}]","Exercise-augmented THSD7B exhibited a positive prognostic implication and tumor-suppressed functionality in pan-cancer | PDF",1789980338]