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This comprehensive meta-analysis systematically evaluates the association between post-diagnosis physical activity and survival across multiple cancer types, including breast, lung, prostate, colorectal, and skin cancers. Eligible studies (January 2000–November 2024) used prospective cohort and case-control designs reporting hazard ratios and 95% confidence intervals for overall or cancer-specific mortality.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/exercise-and-survival-benefit-in-cancer-patients-evidence-from-a-comprehensive-meta-analysis/372456/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/exercise-and-survival-benefit-in-cancer-patients-evidence-from-a-comprehensive-meta-analysis/372456.png","ImageObject",300,407,{"name":92,"@type":93},"Fahsai","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of this meta-analysis?","Question",{"text":112,"@type":113},"To systematically evaluate the association between post-diagnosis physical activity and survival outcomes in cancer patients across multiple cancer types.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which cancer types and study designs were included?",{"text":117,"@type":113},"The analysis included adults with breast, lung, prostate, colorectal, or skin cancer, using prospective cohort and case-control studies that reported hazard ratios with 95% confidence intervals.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the overall relationship between post-diagnosis physical activity and mortality?",{"text":121,"@type":113},"Post-diagnosis physical activity was associated with significantly lower cancer-specific mortality across all five cancer types.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},372456,1790645238,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},549768702563,"https://ap-avatar.wpscdn.com/avatar/8000c4aa63b76e948b?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786536092046926083","GeroScience (2025) 47:5235–5255  \n[https://doi.org/10.1007/s11357-025-01647-0](https://doi.org/10.1007/s11357-025-01647-0)  \nExercise and survival benefit in cancer patients: evidence from a comprehensive meta‑analysis  \nZoltan Ungvari · Mónika Fekete · Péter Varga · Gyöngyi Munkácsy · János Tibor Fekete · Andrea Lehoczki · Annamaria Buda · Csaba Kiss ·  \nAnna Ungvari · Balázs Győrffy  \nReceived: 15 February 2025 / Revised: 1 April 2025 / Accepted: 2 April 2025 / Published online: 12 April 2025 © The Author(s) 2025  \nAbstract Cancer remains a major global health challenge, and growing evidence suggests that physical activity is a key modifiable factor that may improve survival outcomes in cancer patients. However, a comprehensive, large-scale synthesis of the effects of post-diagnosis physical activity across multiple cancer types remains lacking. This metaanalysis aims to systematically evaluate the association between physical activity and survival in patients diagnosed with breast, lung, prostate, colorectal, and skin cancers. We conducted a comprehensive search in PubMed, Web of Science, Scopus, and Cochrane  \nZoltan Ungvari, Mónika Fekete and Péter Varga contributed equally.  \nZ. Ungvari  \nVascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA  \nZ. Ungvari  \nStephenson Cancer Center, University of Oklahoma, Oklahoma City, OK, USA  \nZ. Ungvari  \nOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA  \nZ. Ungvari  \nDepartment of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA  \nLibrary for studies on physical activity and cancer survival. Eligible studies (January 2000–November 2024) included adults (≥ 18 years) with breast, lung, prostate, colorectal, or skin cancer. Only prospective cohort and case–control studies reporting hazard ratios (HRs) with 95% confidence intervals (CIs) for overall or cancer-specific mortality were included, with a minimum sample size of 100 and at least six months of follow-up. Meta-analysis was performed using [metaanalysisonline.com](metaanalysisonline.com), applying randomeffects models and assessing heterogeneity via the I2 statistic. Sensitivity analyses and publication bias (Egger’s test, funnel plots) were evaluated. The metaanalysis included 151 cohorts with almost 1.5 million  \nZ. Ungvari  \nInternational Training Program in Geroscience, Doctoral College, Health Sciences Division/Institute of Preventive Medicine and Public Health, Semmelweis University, Budapest, Hungary  \nM. Fekete · P. Varga · A. Lehoczki · A. Buda ·  \nA. Ungvari (*)  \nInstitute of Preventive Medicine and Public Health, Semmelweis University, Semmelweis University, Budapest, Hungary [e-mail: Ungann2004@gmail.com](e-mail: Ungann2004@gmail.com)  \nM. Fekete · P. Varga · A. Lehoczki · A. Buda  \nJozsef Fodor Center for Prevention and Healthy Aging, Semmelweis University, Budapest, Hungary  \ncancer patients. Post-diagnosis physical activity was associated with significantly lower cancer-specific mortality across all five cancer types. The greatest benefit was observed in breast cancer, with a pooled hazard ratio (HR) of 0.69 (95% CI: 0.63–0.75), followed by prostate cancer (HR: 0.73, 95% CI: 0.62– 0.87) . Lung cancer patients who engaged in physical activity had a 24% lower risk of cancer-specific death (HR: 0.76, 95% CI: 0.69–0. 84), while colorectal cancer patients experienced a similar benefit (HR: 0.71, 95% CI: 0.63–0.80) . In skin cancer, physical activity was associated with a non-significant reduction in mortality (HR: 0.86, 95% CI: 0.71–1.05) . These findings provide robust evidence supporting the survival benefits of post-diagnosis physical activity in cancer patients, particularly for breast, prostate, lung, and colorectal cancers. The results unde","cbCaioQMxkGMqUyK","https://ap.wps.com/l/cbCaioQMxkGMqUyK","pdf",5101129,21,"English","# Abstract\n## Methods and study selection\n## Findings by cancer type\n## Implications for oncological care","[{\"question\":\"What is the main purpose of this meta-analysis?\",\"answer\":\"To systematically evaluate the association between post-diagnosis physical activity and survival outcomes in cancer patients across multiple cancer types.\"},{\"question\":\"Which cancer types and study designs were included?\",\"answer\":\"The analysis included adults with breast, lung, prostate, colorectal, or skin cancer, using prospective cohort and case-control studies that reported hazard ratios with 95% confidence intervals.\"},{\"question\":\"What is the overall relationship between post-diagnosis physical activity and mortality?\",\"answer\":\"Post-diagnosis physical activity was associated with significantly lower cancer-specific mortality across all five cancer types.\"}]","Exercise and survival benefit in cancer patients - evidence from a comprehensive meta-analysis | PDF",1790194565,53]