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LonGenity indicates slower decline and preserved hippocampal subfield volumes, while RUSH MAP finds better late-life cognition without pathology differences. Results suggest behavioral and biological protective 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are “super movers” in this research?","Question",{"text":63,"@type":64},"They are individuals aged 80 and older whose gait speeds are at least 1.5 SD above age- and sex-adjusted means, defining an exceptional aging phenotype.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was cognitive impairment measured and analyzed?",{"text":68,"@type":64},"Incident cognitive impairment was assessed in HRS-INS using cognitive test criteria combined with impaired Instrumental Activities of Daily Living, followed by meta-analysis using age- and sex-adjusted hazard ratios from Cox models.",{"name":70,"@type":61,"acceptedAnswer":71},"What brain health markers distinguish super movers?",{"text":72,"@type":64},"In LonGenity, super movers showed slower memory and non-memory decline and preserved hippocampal subfield volumes.",{"name":74,"@type":61,"acceptedAnswer":75},"Did super movers differ in dementia-related pathology?",{"text":76,"@type":64},"RUSH MAP showed no differences in 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\nHEALTH IN SUPER MOVERS  \nOshadi Jayakody1, Joe Verghese2, Helena Blumen2,  \nSofiya Milman1, Nir Barzilai3, Ying Jin1, Cuiling Wang1, and Erica Weiss1, 1. Albert Einstein College of Medicine, Bronx, New York, United States, 2. Stony Brook University, Stony Brook, New York, United States, 3. Institute for Aging Research, Bronx, New York, United States  \nSuper movers, individuals aged 80 and older with gait speeds ≥1.5 SD above age-and sex-adjusted means, represent an exceptional aging phenotype and may offer insights into resilience against cognitive decline. We examined their risk of incident cognitive impairment, cognitive trajectories and brain health using data from 1) five Health and Retirement Study International Network of Studies (HRS-INS) 2) the LonGenity study and 3) the RUSH Memory Aging Project (RUSH MAP). InHRS-INS we assessed incident cognitive impairment (>1.5 SD below age-adjusted cognitive test means plus impaired Instrumental Activities of Daily Living) of super movers and conduct a meta-analysis using age- and sex-adjusted hazard ratios (HR) from Cox models of individual studies. LonGenity study data were used to model longitudinal cognitive decline using linear mixed-effects models (adjusted for age, sex, education, and parental longevity) and to compare cortical thickness and hippocampal subfield volumes between super versus non-super movers. RUSH MAP data assessed dementia-related pathology in super movers. In pooled HRS-INS data (n = 358/3,989 super movers; baseline age 83.6–84.4 years; follow-up 3.8–6.1 years), super movers had a lower risk of cognitive impairment (HR 0.50, 95% CI 0.29–0.71). In LonGenity (n = 197; mean age 84.6, SD 3.3), super movers exhibited slower decline in memory and non-memory domains and preserved hippocampal subfield volumes. In RUSH MAP, they had better late-life cognition, despite no differences in dementia-related pathology. Understanding the behavioral and biological traits of super movers may reveal protective mechanisms against cognitive decline and dementia to inform future interventions.","cbCaieBLIYF1cYjO","https://ap.wps.com/l/cbCaieBLIYF1cYjO","pdf",1080353,"English","# Exceptional Aging and Super Movers\n## Study design and data sources (HRS-INS, LonGenity, RUSH MAP)\n## Cognitive impairment risk and trajectories\n## Brain health findings and pathology results\n## Implications for protective mechanisms and interventions","[{\"question\":\"What are “super movers” in this research?\",\"answer\":\"They are individuals aged 80 and older whose gait speeds are at least 1.5 SD above age- and sex-adjusted means, defining an exceptional aging phenotype.\"},{\"question\":\"How was cognitive impairment measured and analyzed?\",\"answer\":\"Incident cognitive impairment was assessed in HRS-INS using cognitive test criteria combined with impaired Instrumental Activities of Daily Living, followed by meta-analysis using age- and sex-adjusted hazard ratios from Cox models.\"},{\"question\":\"What brain health markers distinguish super movers?\",\"answer\":\"In LonGenity, super movers showed slower memory and non-memory decline and preserved hippocampal subfield volumes.\"},{\"question\":\"Did super movers differ in dementia-related pathology?\",\"answer\":\"RUSH MAP showed no differences in dementia-related pathology, even though super movers had better late-life cognition.\"}]","EXCEPTIONAL AGING: COGNITIVE AND BRAIN HEALTH IN SUPER MOVERS | PDF",1790645304]