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TT was most frequent in affected individuals, while CC appeared more in healthy participants. Associations were also observed with sex, tumor invasion, tumor grade, and tumor size/degree, supporting rs10811661 as a prognostic biomarker.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/evaluation-of-rs10811661-polymorphism-in-cdkn2ab-in-colon-and-gastric-cancer/379334/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/evaluation-of-rs10811661-polymorphism-in-cdkn2ab-in-colon-and-gastric-cancer/379334.png","ImageObject",300,407,{"name":42,"@type":43},"Dipper","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the purpose of evaluating rs10811661 in CDKN2A/B?","Question",{"text":63,"@type":64},"To determine whether rs10811661 polymorphism can serve as an effective biomarker for colon cancer and support early detection of gastric cancer.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were genotypes determined in the study?",{"text":68,"@type":64},"Genotypes were identified from blood samples using a PCR-RFLP approach, followed by allelic and genotypic analyses with SPSS software.",{"name":70,"@type":61,"acceptedAnswer":71},"What genotype patterns were reported between healthy and affected individuals?",{"text":72,"@type":64},"The results confirmed the highest frequency of TT genotypes among affected individuals, while the CC genotype was more common in healthy individuals.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},379334,1791071252,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":115,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},1374404997633,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Beihaghi etal. BMC Cancer (2023) 23:985 [https://doi.org/10.1186/s12885-023-11461-6](https://doi.org/10.1186/s12885-023-11461-6)  \nBMC Cancer  \nRESEARCH Open Access  \nEvaluation of rs10811661 polymorphism in CDKN2A / B in colon and gastric cancer  \nMaria Beihaghi 1,2*, Reza Sahebi3, Mohammad Reza Beihaghi4, Raheleh Khosravi Nessiani5, Majedeh RamianYarasmi6, Sajad Gholamalizadeh 1, Fatemeh Shahabnavaie7 and Mitra shojaei3  \nAbstract  \nOne of the causes of colon and gastric cancer is the dysregulation of carcinogenic genes, tumor inhibitors, and micro-RNA. The purpose of this study is to apply rs10811661 polymorphism in CDKN2A /B gene as an effective biomarker of colon cancer and early detection of gastric cancer. As a result,400 blood samples, inclusive of 200 samples from healthy individuals and 200 samples (100 samples from intestinal cancer,100 samples from stomach cancer) from the blood of someone with these cancers, to determine the genotype of genes in healthful and ill people through PCR-RFLP approach and Allelic and genotypic tests of SPSS software. To observe the connection between gastric cancer and bowel cancer risk and genotypes, the t-student test for quantitative variables and Pearson distribution for qualitative variables have been tested and the results have been evaluated using the Chi-square test. The effects confirmed that the highest frequency of TT genotypes is in affected individuals and CC genotype is in healthful individuals. In addition, it confirmed that women were more inclined than men to T3 tumor invasion and most grade II and III colon cancers, and in older sufferers with gastric cancer, the grade of tumor tended to be grade I. Among genetic variety and rs10811661, with invasiveness, there is a tumor size and degree in the affected person. In summary, our findings suggest that the rs10811661 polymorphism of the CDKN2A / B gene is strongly associated with the occurrence of intestinal cancer and stomach is linked to its potential role as a prognostic biomarker for the management of bowel cancer and stomach.  \nKeywords Colon cancer, CDKN2A / B gene, Polymorphism rs10811661, Statistical analysis, RFLP-PCR, Gastric Cancer, Biomarker  \n*Correspondence:  \nMaria Beihaghi  \n[maria_beihaghi@yahoo.com](maria_beihaghi@yahoo.com)  \n1Department of Biology, Kavian Institute of Higher Education, Mashhad, Iran  \n2School of Science and Technology, The University of Georgia, Tbilisi, Georgia  \n3Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran  \n4Department of Public Health, Sheffield Hallam University, Sheffield, South Yorkshire, England  \n5Department of Chemical Engineering, Sahand University of Technology, Tabriz, Iran  \n6Department of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran  \n7Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran  \nIntroduction  \nGastric cancer (GC) is the fifth most common cancer and the third main cause of cancer deaths, accounting for about 800,000 deaths annually [1]. In popular, the common age of onset is 60 to eighty years, and under 30 years is rare. For this reason, GC is taken into consideration as an aging sickness [2, 3]. The countries of East Asia, accompanied by Eastern Europe and South America, have the highest rates of infection. The lowest rates are observed in North America and Africa. However, the prevalence of GC has decreased in most countries, and regardless of advances in diagnosis, the ailment is normally recognized at advanced levels, in particular,  \n© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material i","cbCaitfAzUD2Wazs","https://ap.wps.com/l/cbCaitfAzUD2Wazs","pdf",1206491,"English","# Abstract\n# Keywords\n# Introduction","[{\"question\":\"What is the purpose of evaluating rs10811661 in CDKN2A/B?\",\"answer\":\"To determine whether rs10811661 polymorphism can serve as an effective biomarker for colon cancer and support early detection of gastric cancer.\"},{\"question\":\"How were genotypes determined in the study?\",\"answer\":\"Genotypes were identified from blood samples using a PCR-RFLP approach, followed by allelic and genotypic analyses with SPSS software.\"},{\"question\":\"What genotype patterns were reported between healthy and affected individuals?\",\"answer\":\"The results confirmed the highest frequency of TT genotypes among affected individuals, while the CC genotype was more common in healthy individuals.\"}]","Evaluation of rs10811661 polymorphism in CDKN2A/B in colon and gastric cancer | PDF",1790235156,23]