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The study includes 38 early-stage NSCLC patients and 29 controls, with serum VEGF and endocan measured before and 1 month after surgery. 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Patients underwent surgery and were monitored for 1 month postoperatively.",{"name":120,"@type":111,"acceptedAnswer":121},"What did the results show for VEGF compared with endocan?",{"text":122,"@type":114},"Preoperative VEGF was significantly higher in patients and decreased after surgery. Endocan levels were similar preoperatively but increased after surgery, without significant differences by TNM staging or tumor histopathology.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},455296,1791033721,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},962090893153,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Turkish Journal of Medical Sciences  \n\n| Volume 55  Number 6 | Article 9 |\n| --- | --- |\n| 12-12-2025\u003Cbr>Evaluation of prognostic value of vascular endothelial growth\u003Cbr>factor and endocan in non-small cell lung cancer MESUT MELİH ÖZERCAN\u003Cbr>BURCU ANCIN\u003Cbr>YİĞİT YILMAZ\u003Cbr>AHMET MÜDERRİSOĞLU\u003Cbr>SERKAN UYSAL\u003Cbr>See next page for additional authors\u003Cbr>Follow this and additional works at: [https://journals.tubitak.gov.tr/medical](https://journals.tubitak.gov.tr/medical)\u003Cbr> Part of the Medical Sciences Commons |  |\n\nRecommended Citation  \nÖZERCAN, M. M, ANCIN, B, YILMAZ, Y, MÜDERRİSOĞLU, A, UYSAL, S, KUMBASAR, U, SARIBAŞ, Z, DİKMEN, E, & DOĞAN, R (2025) . Evaluation of prognostic value of vascular endothelial growth factor and endocan in non-small cell lung cancer. Turkish Journal of Medical Sciences 55 (6): 1424-1434.  \n[https://doi.org/10.55730/1300-0144.6100](https://doi.org/10.55730/1300-0144.6100)  \nThis work is licensed under a Creative Commons Attribution 4.0 International License.  \nThis Research Article is brought to you for free and open access by TÜBİTAK Academic Journals. It has been accepted for inclusion in Turkish Journal of Medical Sciences by an authorized editor of TÜBİTAK Academic Journals. For more information, please contact [academic.publications@tubitak.gov.tr](academic.publications@tubitak.gov.tr)  \nEvaluation of prognostic value of vascular endothelial growth factor and endocan in non-small cell lung cancer  \nAuthors  \nMESUT MELİH ÖZERCAN, BURCU ANCIN, YİĞİT YILMAZ, AHMET MÜDERRİSOĞLU, SERKAN UYSAL, ULAŞ KUMBASAR, ZEYNEP SARIBAŞ, ERKAN DİKMEN, and RIZA DOĞAN  \nThis research article is available in Turkish Journal of Medical Sciences: [https://journals.tubitak.gov.tr/medical/](https://journals.tubitak.gov.tr/medical/)[ ](https://journals.tubitak.gov.tr/medical/)vol55/iss6/9  \n\n| \u003Cbr>| Turkish Journal of Medical Sciences [http://journals.tubitak.gov.tr/medical/](http://journals.tubitak.gov.tr/medical/)\u003Cbr>\u003Cbr>Research Article | Turk J Med Sci\u003Cbr>(2025) 55: 1424-1434 © TÜBİTAK\u003Cbr>doi:10.55730/1300-0144.6100 |\n| --- | --- | --- |\n\nEvaluation of prognostic value of vascular endothelial growth factor and endocan in  \nnon-small cell lung cancer  \nMesut Melih ÖZERCAN1,*􀁋, Burcu ANCIN2􀁋, Yiğit YILMAZ3􀁋, Ahmet MÜDERRİSOĞLU4􀁋, Serkan UYSAL3􀁋, Ulaş KUMBASAR3􀁋, Zeynep SARIBAŞ5􀁋, Erkan DİKMEN3􀁋, Rıza DOĞAN6􀁋  \n1  \nDepartment of Thoracic Surgery, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkiye 2  \nDepartment of Thoracic Surgery, Burdur State Hospital, Burdur, Turkiye  \n3  \nDepartment of Thoracic Surgery, Faculty of Medicine, Hacettepe University, Ankara, Turkiye  \n4  \nDepartment of Pharmacology, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkiye 5  \nDepartment of Medical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkiye 6  \nEmeritus, Department of Thoracic Surgery, Faculty of Medicine, Hacettepe University, Ankara, Turkiye  \nReceived: 26.06.2025  Accepted/Published Online: 05.10.2025  Final Version: 12.12.2025  \nBackground/aim: No reliable, easily measurable biomarker currently exists for the screening or prognosis of lung cancer. The present study evaluates the potential utility of vascular endothelial growth factor (VEGF) and endocan, which can be readily measured in blood samples, as biomarkers for screening and prognostic assessment in lung cancer.  \nMaterials and methods: Included in the study were 38 patients with early-stage non-small cell lung cancer (NSCLC) and 29 controls. All patients underwent surgical intervention and were monitored for 1 month postoperatively. Serum VEGF and endocan levels were measured preoperatively and postoperatively. Clinical characteristics, laboratory data, and histopathological findings were recorded for all participants.  \nResults: The preoperative VEGF levels of the patients were significantly higher than those of the controls (p = 0.001), while postoperative VEGF levels decreased significantly following surgery (p \u003C 0.001) . The end","cbCaicydkqw0fCk2","https://ap.wps.com/l/cbCaicydkqw0fCk2","pdf",672741,14,"English","# Background/aim\n# Materials and methods\n# Results\n# Conclusion\n# Key words\n# Introduction","[{\"question\":\"What was the study aim regarding VEGF and endocan?\",\"answer\":\"To evaluate the potential utility of VEGF and endocan as biomarkers for screening and prognostic assessment in non-small cell lung cancer.\"},{\"question\":\"How many participants were included and how were they followed?\",\"answer\":\"The study included 38 early-stage NSCLC patients and 29 controls. Patients underwent surgery and were monitored for 1 month postoperatively.\"},{\"question\":\"What did the results show for VEGF compared with endocan?\",\"answer\":\"Preoperative VEGF was significantly higher in patients and decreased after surgery. Endocan levels were similar preoperatively but increased after surgery, without significant differences by TNM staging or tumor histopathology.\"}]","Evaluation of prognostic value of vascular endothelial growth factor and endocan in non-small cell lung cancer | PDF",1790742555,35]