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This study evaluates hematological parameters—including red cell indices and platelet-related measures in conjunction with white cell indices—to assess links with glycemic control. In a cross-sectional observational design with 120 participants (90 T2DM patients; 30 matched controls), CBC was analyzed and HbA1c was measured by HPLC, then T2DM patients were stratified into good, moderate, and poor control groups. Higher WBC, NLR, and MPV corresponded with poorer glycemic control.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/evaluation-of-hematological-changes-in-type-2-diabetes-mellitus-and-their-correlation-with-glycemic-control/460273/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/evaluation-of-hematological-changes-in-type-2-diabetes-mellitus-and-their-correlation-with-glycemic-control/460273.png","ImageObject",300,407,{"name":92,"@type":93},"A glass of water","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-10","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How were glycemic control groups defined in the study?","Question",{"text":112,"@type":113},"T2DM patients were divided into good, moderate, and poor glycemic control based on HbA1c thresholds: good (≤7.0%), moderate (7.1–8.5%), and poor (≥8.5%).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which hematological parameters showed significant differences between T2DM patients and controls?",{"text":117,"@type":113},"T2DM patients had higher total leukocyte count and neutrophil-to-lymphocyte ratio compared with controls. Mean platelet volume was also higher in poorly controlled patients than in well controlled ones.",{"name":119,"@type":110,"acceptedAnswer":120},"What relationships were reported between HbA1c and blood parameters?",{"text":121,"@type":113},"The study reported a negative relationship between HbA1c and hemoglobin levels, and positive relationships between HbA1c and both WBC count and MPV.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},460273,1790758117,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":129,"read_time":39,"preview_page_count":4},962090760832,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Original Research  \nEvaluation of Hematological Changes in Type 2 Diabetes Mellitus and Their Correlation with Glycemic Control  \nAmisha Khungala1, Vacha Patel2, Mrudali Babaria3, Rahul Bhaveshbhai Vaghasiya4, Sangeeta Gupta5  \n1Department of Medicine, GMERS General Hospital, Junagadh, Gujarat, India, 2Department of Anesthesia, Dr. N. D. Desai Faculty of Medical Science and Research, Dharmsinh Desai University, Nadiad, Gujarat, India, 3Department of Obstetrics and Gynecology, GMERS Medical College and Hospital, Vadnagar, Gujarat, India, 4Department of Medicine, GMERS General Hospital, Junagadh, Gujarat, India, 5Department of Physiology, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India  \nSubmitted: 21‑Jun‑2025  \nRevised: 15‑Jul‑2025  \nAccepted: 26‑Jul‑2025  \nPublished: 17‑Dec‑2025  \nAbstract  \nBackground: T2DM is known to cause chronic hyperglycemia and results ina set of systemic complications. Hematological parameters, red cell indices testing, and platelet parameters in combination with white cell count may also become the parameters of inflammatory status and glycemic control. Materials and Methods: Patients diagnosed with T2DM were enrolled in across‑sectional observational study with 120 subjects (90 diagnosed with T2DM and 30 age‑ and sex‑matched controls) . An automated hematology analyser was used to carry out complete blood counts (CBC) . The measurements that were conducted on HbA1c used HPLC. The T2DM patients were divided into three groups based on glycemic control; there were good glycemic control (HbA1c 7.0% or less), moderate (HbA1c 7.1‑8.5%), and poor control (HbA1c 8.5% or more) . Results: The T2DM patients had a considerable increment in total leukocyte count (mean = 8.94 10 9/L) and neutrophil‑to‑lymphocyte ratio (NLR = 2.97) as compared with the controls (mean WBC = 6.21 10 9/L, NLR = 1.85) . The mean platelet volume (MPV) value was higher in poorly‑controlled diabetics (11.2 fL) than in the well‑controlled ones (9.4 fL) . There was a negative relationship between HbA1c and hemoglobin levels (r = –0.45, P = 0.01), whereas positive relationships with HbA1c and WBC count (r = 0.38, P = 0.02) and MPV (r = 0.42, P = 0.01), respectively. Conclusion: T2DM is linked with immense changes in blood and lab values, especially among those with mixed glycemic control. Higher WBC, MPV, and NLR indicate a low level of inflammation and hyperactivity of platelets, which might also be a risk factor that leads to complications of diabetes.  \nKeywords: Complete blood count, HbA1c, inflammation, hematological  \nparameters, glycemic control, type 2 diabetes mellitus   \nIntroduction  \nype 2 diabetes mellitus (T2DM) is a developing  \nimn-etreasbolicistant, condrelatitiioven itnhatsulin isinsnoteufficidencty,o abned continuous hyperglycemia. It is a high global health burden that is known to enhance morbidity and mortality because of its systemic complications such as cardiovascular disease, nephropathy, retinopathy, and neuropathy.[1] T2DM is also characterized by a pro-inflammatory status and an abnormal hematological profile in addition to the metabolic abnormalities, and they are becoming significant in assessing disease progression and complications development.[2]  \n\n| Access this article online |  |\n| --- | --- |\n| Quick Response Code:\u003Cbr>| Website: [https://journals.lww.com/jpbs](https://journals.lww.com/jpbs) |\n|  | DOI: 10.4103/jpbs.jpbs_1111_25 |\n\nThese include elevated total leukocyte counts, altered red blood cell (RBC) indices, elevated platelet counts, and higher mean platelet volume (MPV) in T2DM patients. These changes could be considered an indicator of low-level persistent inflammation and endothelial dysfunction.[3] Hyperglycemia leads to oxidative stress and glycation of blood proteins that might influence the hematopoiesis process and structural stability of the  \n\n| Address for correspondence: Dr. Rahul Bhaveshbhai Vaghasiya, Department of Medicine, GMERS General Hospital, Junagadh, Gu","cbCaibqiKCKOZ58R","https://ap.wps.com/l/cbCaibqiKCKOZ58R","pdf",595189,"English","# Abstract\n## Background\n## Materials and Methods\n## Results\n## Conclusion\n# Introduction\n# Materials and Methods","[{\"question\":\"How were glycemic control groups defined in the study?\",\"answer\":\"T2DM patients were divided into good, moderate, and poor glycemic control based on HbA1c thresholds: good (≤7.0%), moderate (7.1–8.5%), and poor (≥8.5%).\"},{\"question\":\"Which hematological parameters showed significant differences between T2DM patients and controls?\",\"answer\":\"T2DM patients had higher total leukocyte count and neutrophil-to-lymphocyte ratio compared with controls. Mean platelet volume was also higher in poorly controlled patients than in well controlled ones.\"},{\"question\":\"What relationships were reported between HbA1c and blood parameters?\",\"answer\":\"The study reported a negative relationship between HbA1c and hemoglobin levels, and positive relationships between HbA1c and both WBC count and MPV.\"}]","Evaluation of Hematological Changes in Type 2 Diabetes Mellitus and Their Correlation with Glycemic Control | PDF"]