[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-428122-105":59,"doc-detail-428122-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","evaluating-randomized-assessment-timing-design-in-a-simulation-study","EVALUATING RANDOMIZED ASSESSMENT TIMING - DESIGN IN A SIMULATION STUDY","","Longitudinal studies are central to aging research, yet fixed follow-up schedules can confound time-related factors with treatment or group effects and restrict exploration of alternative schedules. A randomized follow-up design randomizes the timing of selected measurements across subjects within a longitudinal study. Simulation studies show reduced bias for between-group comparisons and improved mean squared error when extrapolating beyond fixed-time points, supporting use in clinical trials and observational studies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/evaluating-randomized-assessment-timing-design-in-a-simulation-study/428122/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/evaluating-randomized-assessment-timing-design-in-a-simulation-study/428122.png","ImageObject",300,407,{"name":92,"@type":93},"Đào","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-17","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What problem does the study address in longitudinal aging research?","Question",{"text":112,"@type":113},"Fixed follow-up schedules can conflate time-related factors with treatment or group effects, and they limit the ability to explore alternative follow-up schedules or richer information.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the proposed design work?",{"text":117,"@type":113},"The study proposes a randomized follow-up design that randomizes the timing of some follow-up measurements across subjects within a longitudinal study.",{"name":119,"@type":110,"acceptedAnswer":120},"What do the simulation studies show about the design’s performance?",{"text":121,"@type":113},"Simulations indicate substantially reduced bias for between-group differences and improved mean squared error when predicting outcomes across time points not covered by fixed-time designs.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},428122,1791376541,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},1374402968488,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","1064 Innovation in Aging, 2025, Vol. 9, No. S2  \ntime-related factors from being conflated with treatment or group effects. While this approach maintains internal validity, it can also limit the ability to explore alternative follow-up schedules that might yield richer information or greater efficiency. We propose a randomized follow-up design, in which the timing of some follow-up measurements is randomized across subjects within a longitudinal study. This approach has the potential to better estimate the underlying trajectory of change. Through a series of simulation studies, we demonstrate that the proposed design can substantially reduce bias when estimating between-group differences and when extrapolating to time points not covered in a fixed-time design. It also improves the overall mean squared error in predicting outcomes across all time points, when higher-order terms in the trajectory cannot be estimated due to insufficient data. This design may be valuable for both clinical trials and prospective observational studies in settings where the trajectory pattern is unknown at the design stage. The promising simulation results motivate further application to real data, to assess the utility of the design in reducing participant burden in data collection while increasing statistical power for trajectory estimation.  \nAbstract citation ID: igaf122.3580  \nEVALUATING RANDOMIZED ASSESSMENT TIMING  \nDESIGN IN A SIMULATION STUDY  \nWenshan Yu, Valerie Smith, and Sarah Peskoe,  \nDuke University, Durham, North Carolina, United States Longitudinal studies are vital in aging research because they  \nenable researchers to trace trajectories of risk factors and outcomes, such as pain, physical and cognitive function, and biomarkers. In a typical longitudinal design, follow-up time is predetermined and fixed for every individual to ensure that differences in outcomes can be attributed to true temporal changes rather than variability in measurement timing, and to prevent","cbCaionCmi5J6nio","https://ap.wps.com/l/cbCaionCmi5J6nio","pdf",926714,"English","# EVALUATING RANDOMIZED ASSESSMENT TIMING DESIGN IN A SIMULATION STUDY\n## Problem with fixed assessment timing\n## Proposed randomized assessment timing design\n## Simulation results and implications\n## Future directions with real data","[{\"question\":\"What problem does the study address in longitudinal aging research?\",\"answer\":\"Fixed follow-up schedules can conflate time-related factors with treatment or group effects, and they limit the ability to explore alternative follow-up schedules or richer information.\"},{\"question\":\"How does the proposed design work?\",\"answer\":\"The study proposes a randomized follow-up design that randomizes the timing of some follow-up measurements across subjects within a longitudinal study.\"},{\"question\":\"What do the simulation studies show about the design’s performance?\",\"answer\":\"Simulations indicate substantially reduced bias for between-group differences and improved mean squared error when predicting outcomes across time points not covered by fixed-time designs.\"}]","EVALUATING RANDOMIZED ASSESSMENT TIMING - DESIGN IN A SIMULATION STUDY | PDF",1790645866]