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Among 74 strains, susceptibility was 100% for TGC and 87.8% for ERV, with MIC ranges of 0.125–2 μg/mL. Differences depended on carbapenemase type, sequence type, and age group, with carbapenemase type as the primary determinant. ERV showed higher inhibition when MIC was \u003C0.5 μg/mL and comparable effects at other tested MIC levels.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/evaluating-eravacyclines-efficacy-against-pediatric-carbapenem-resistant-klebsiella-pneumoniae-in-china-a-6-year-study/446796/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/evaluating-eravacyclines-efficacy-against-pediatric-carbapenem-resistant-klebsiella-pneumoniae-in-china-a-6-year-study/446796.png","ImageObject",300,407,{"name":92,"@type":93},"Ben ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-05","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main goal of this study?","Question",{"text":112,"@type":113},"To evaluate the in vitro efficacy of eravacycline (ERV) against pediatric carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates and compare it with tigecycline (TGC).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How many pediatric CRKP isolates were tested and what were the susceptibility results?",{"text":117,"@type":113},"A total of 74 CRKP strains were tested; susceptibility was 100% for TGC and 87.8% for ERV.",{"name":119,"@type":110,"acceptedAnswer":120},"Which factor most strongly influenced ERV susceptibility?",{"text":121,"@type":113},"The type of carbapenemase was identified as the primary determinant of ERV susceptibility across carbapenemases, sequence types, and age groups.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},446796,1791165851,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46},2336478951081,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","| Antimicrobial Chemotherapy | Research Article  \nEvaluating eravacycline’s efficacy against pediatric carbapenemresistant Klebsiella pneumoniae in China: a 6-year study  \nMingming Zhou,1 Xiucai Zhang,1 Shixing Liu,1 Jintao Xia,1 Chao Fang,1 Yining Zhao,1 Hongqiang Shen1  \nAUTHOR AFFILIATION See affiliation list on p. 7.  \nABSTRACT Eravacycline (ERV) has demonstrated promising in vitro antibacterial activity against carbapenem-resistant Klebsiella pneumoniae (CRKP) . Nonetheless, its clinical application in pediatric cases remains underexplored. Therefore, we assessed the in vitro activities of ERV and tigecycline (TGC) against CRKP isolates obtained from pediatric patients in China between 2019 and 2024. The susceptibility rates of the 74 CRKP strains to TGC and ERV were 100% and 87.8%, respectively. Both TGC and ERV had MIC ranges of 0.125–2 μg/mL, with MIC50 at 0.25 µg/mL and MIC90 at 1 µg/mL. Statistically significant differences in ERV susceptibility were observed across different carbapenemases, sequence types (STs), and age groups, with the type of carbapenemase emerging as the primary determinant. The lowest susceptibility was noted for blaKPC-2 (64.3%) and ST11 (54.6%), while blaNDM-1 (97.4%), ST25, and ST17 (100%) exhibited the highest. The lowest susceptibility was observed in CRKP strains isolated from >3-year group (46.7%), whereas strains from both neonates and toddlers exhibited 100% susceptibility. When the MIC was below 0.5 µg/mL, ERV exhibited higher inhibition rates against CRKP compared to TGC. However, at MIC values of 0.5, 0.75, 1.5, and 2 µg/mL, the inhibition rates of both drugs were comparable. Among CRKP strains carrying blaKPC-2, blaNDM-1, and blaNDM-5, both the MIC50 and MIC90 values of ERV were less than or equal to TGC’s. ERV consistently had lower or equal MIC90 values compared to TGC for common STs, except for ST11, where ERV’s MIC50 was also lower or equal. ERV demonstrated significant in vitro activity against pediatric CRKP isolates collected over a 6-year period, supporting its potential benefits in treating pediatric CRKP infections, although further in vivo validation is necessary.  \nIMPORTANCE Eravacycline (ERV) has demonstrated promising in vitro antibacterial activity against carbapenem-resistant Klebsiella pneumoniae (CRKP) . Current research predominantly addresses adult populations, leaving its clinical application in pediatric cases insufficiently explored. Given that the resistance mechanisms of CRKP in pediatric patients differ from those in adults, primarily due to the production of metallo-β-lactamases, and considering that ERV, like tigecycline, may be used off-label in pediatric populations, this study was conducted. The results demonstrate that ERV exhibited significant in vitro efficacy against pediatric CRKP isolates. However, unlike previous studies, the susceptibility rates of ERV vary considerably across different carbapenemases, sequence types, and age groups of CRKP, with the type of carbapenemase emerging as the primary determinant. These findings suggest that ERV has promising in vitro activity against CRKP isolates from pediatric patients, indicating potential clinical applicability for this demographic.  \nKEYWORDS eravacycline, tigecycline, carbapenem-resistant Klebsiella pneumoniae, CRKP, children  \nEditor Gabriele Arcari, Universita degli Studi dell'Insubria, Varese, Italy  \nAddress correspondence to Hongqiang Shen, [shenhq@zju.edu.cn](shenhq@zju.edu.cn).  \nMingming Zhou and Xiucai Zhang contributed equally to this article. Author order was determined in order of decreasing seniority.  \nauthors declare conflict of interest  \nC arbapenem-resistant Klebsiella pneumoniae (CRKP) is increasingly acknowledged as  \na significant public health threat. In the 2024 World Health Organization bacterial priority pathogens list, CRKP received the highest overall ranking (1) . CRKP is capable of causing a range of severe diseases in pediatric populations, including bloodstream ","cbCaite7GhlQZfyS","https://ap.wps.com/l/cbCaite7GhlQZfyS","pdf",289221,"English","# Abstract\n## Importance\n## Background and context\n## Tigecycline use and limitations\n## Alternatives and resistance considerations\n## Eravacycline as a next-generation option","[{\"question\":\"What was the main goal of this study?\",\"answer\":\"To evaluate the in vitro efficacy of eravacycline (ERV) against pediatric carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates and compare it with tigecycline (TGC).\"},{\"question\":\"How many pediatric CRKP isolates were tested and what were the susceptibility results?\",\"answer\":\"A total of 74 CRKP strains were tested; susceptibility was 100% for TGC and 87.8% for ERV.\"},{\"question\":\"Which factor most strongly influenced ERV susceptibility?\",\"answer\":\"The type of carbapenemase was identified as the primary determinant of ERV susceptibility across carbapenemases, sequence types, and age groups.\"}]","Evaluating eravacycline’s efficacy against pediatric carbapenem-resistant Klebsiella pneumoniae in China - a 6-year study | PDF",1790717245]