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The document provides state-of-the-art work-up and management suggestions, including technical guidance on imaging and pathology plus directions for further biological examinations. In the absence of current phase III trials, it aims to serve as a consensus comparator for future studies, assuming essential facilities, medicines, and expertise are available.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/european-standard-clinical-practice-recommendations-for-children-and-adolescents-with-primary-and-relapsed-osteosarcoma-version-1-2023-04-26/461168/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/european-standard-clinical-practice-recommendations-for-children-and-adolescents-with-primary-and-relapsed-osteosarcoma-version-1-2023-04-26/461168.png","ImageObject",300,407,{"name":92,"@type":93},"gewufjwa","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What patient populations does this ESCP guidance cover for osteosarcoma?","Question",{"text":112,"@type":113},"The guidance covers treatment of primary localized osteosarcoma as well as metastatic and relapsed osteosarcoma in children and adolescents.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What kinds of recommendations are included in the document?",{"text":117,"@type":113},"It includes state-of-the-art work-up and management suggestions, spanning diagnostics, treatment, and supportive care, with technical guidance on imaging and pathology.",{"name":119,"@type":110,"acceptedAnswer":120},"How should clinicians use these recommendations according to the disclaimer?",{"text":121,"@type":113},"The guidance is not a clinical trial protocol; responsibility for interpretation and treatment decisions lies with the user, including checking doses and other relevant medical information.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},461168,1791938752,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},3985747882900,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","EUROPEAN STANDARD CLINICAL PRACTICE RECOMMENDATIONS FOR CHILDREN AND ADOLESCENTS WITH PRIMARY AND RELAPSED OSTEOSARCOMA  \nINTRODUCTORY PAGES  \n• EUROPEAN STANDARD CLINICAL PRACTICE RECOMMENDATIONS FOR CHILDREN AND ADOLESCENTS WITH PRIMARY AND RELAPSED OSTEOSARCOMA  \n• European standard-of-care guidelines for osteosarcoma  \n• version 1 2023-04-26  \nThis document has been developed by:  \nDr. Roelof van Ewijk  \nClinical research fellow in pediatric oncology Princess Máxima Center for pediatric oncology Utrecht, the Netherlands  \nDr. Nikolas Herold  \nAssociate professor, fellow in pediatric oncology  \nAstrid Lindgren's Children Hospital Karolinska University Hospital Stockholm, Sweden  \nSupervised by  \nProfessor Dr. Leo Kager  \nSt. Anna Children’s Hospital & St. Anna Children’s Cancer Research Institute Department of Pediatrics, Medical University Vienna  \nVienna, Austria  \nProfessor Dr. Stefan S. Bielack  \nKlinikum Stuttgart-Olgahospital Stuttgart, Germany  \nPlanned review date  \n2028-04-26  \nThis document contains guidance for the treatment of primary localized as well as metastatic and relapsedosteosarcoma, including diagnostics, treatment and supportive care. This guidance document assumes the availability of essential facilities, supportive care, medicines and expertise to provide care for the intensive and complex treatments.  \nThis document provides state-of-the-art work-up and management suggestions, including technical guidance on imaging, pathology, and suggestions for further biological examinations. In the absence of current ongoing phase III trials, it aims to provide a consensus document which might be considered standard-of-care and act as a comparator for future phase III trials in childhood and adolescent osteosarcoma.  \nThe document has been developed in collaboration with (alphabetical) :  \n\n| Fredrik Baecklund | Pediatric Oncology, Astrid Lindgren's Children Hospital, Karolinska University Hospital, Stockholm, Sweden & Childhood Cancer Research Unit, Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden |\n| --- | --- |\n| Daniel Baumhoer | Bone Tumor Reference Center at the Institute of Medical Genetics and Pathology, University Hospital and University of Basel, Switzerland |\n| Kjetil Boye | Department of Oncology, Oslo University Hospital, Norway |\n| Nathalie Gaspar | Department of Oncology for Child and Adolescents, Gustave Roussy Cancer Center, Paris-Saclay University, Villejuif, France |\n| Semi B. Harrabi | Heidelberg Ion Beam Therapy Center (HIT), Department of Radiation Oncology, University Hospital Heidelberg, Germany |\n| Lianne M. Haveman | Pediatric Oncology, Princess Máxima Center for pediatric oncology, Utrecht, the Netherlands |\n| Stefanie Hecker-Nolting | Pediatric Oncology, Klinikum Stuttgart-Olgahospital, Stuttgart, Germany |\n| Laura Hiemcke-Jiwa | Department of Pathology, Princess Máxima Center for pediatric oncology, Utrecht, the Netherlands |\n| Valentine Martin | Department of Radiation Oncology, Gustave Roussy Cancer Center, Villejuif, France |\n| Cristina Mata Fernández | Hospital Universitario Materno Infantil Gregorio Marañón. Pediatric and Adolescent Oncohematology Unit, Madrid, Spain |\n| Emanuela Palmerini | Department of Oncology, Bone and Soft Tissue Sarcomas and Innovative Therapies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy |\n| Michiel A.J. van de Sande | Department of Orthopedic Surgery, Princess Máxima Center for pediatric oncology, Utrecht, the Netherlands\u003Cbr>Department of Orthopedic Surgery, Leiden University Medical Center, Leiden, the Netherlands |\n| Sandra J. Strauss | Department of Oncology, University College London Hospitals NHS Foundation Trust (UCLH), London, UK |\n\nDISCLAIMER:  \nThese ESCP guidance documents were produced by the relevant tumor group or specialist committee as recommendations on current best practice. The ESCP guidance documents are not clinical trial protocols.  \nThe interpretation and responsibility of the use of ESC","cbCaib4JI4NlHXDW","https://ap.wps.com/l/cbCaib4JI4NlHXDW","pdf",1889998,69,"English","# Introduction\n# Methodology\n# Background","[{\"question\":\"What patient populations does this ESCP guidance cover for osteosarcoma?\",\"answer\":\"The guidance covers treatment of primary localized osteosarcoma as well as metastatic and relapsed osteosarcoma in children and adolescents.\"},{\"question\":\"What kinds of recommendations are included in the document?\",\"answer\":\"It includes state-of-the-art work-up and management suggestions, spanning diagnostics, treatment, and supportive care, with technical guidance on imaging and pathology.\"},{\"question\":\"How should clinicians use these recommendations according to the disclaimer?\",\"answer\":\"The guidance is not a clinical trial protocol; responsibility for interpretation and treatment decisions lies with the user, including checking doses and other relevant medical information.\"}]","EUROPEAN STANDARD CLINICAL PRACTICE RECOMMENDATIONS FOR CHILDREN AND ADOLESCENTS WITH PRIMARY AND RELAPSED OSTEOSARCOMA - version 1 - 2023-04-26 | PDF",1790760791,174]