[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-450109-105":59,"doc-detail-450109-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","ethylene-glycol-poisoning-with-oxalate-nephropathy-and-acute-kidney-injury-a-case-report-and-review-of-the-literature","Ethylene Glycol Poisoning With Oxalate Nephropathy and Acute Kidney Injury - A Case Report and Review of the Literature","","Ethylene glycol is a hazardous alcohol found in household and industrial products. After metabolism by alcohol dehydrogenase and aldehyde dehydrogenase, it generates glycolate, acetaldehyde, and oxalate, which can drive acute kidney injury through tubular injury and oxalate crystal precipitation. A 35-year-old man presented unconscious after suspected ingestion, with metabolic acidosis, acute kidney injury, and hyperkalemia. Biopsy confirmed acute tubular necrosis with oxalate crystals, and treatment with fluids, bicarbonate, alcohol administration, and hemodialysis led to recovery.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ethylene-glycol-poisoning-with-oxalate-nephropathy-and-acute-kidney-injury-a-case-report-and-review-of-the-literature/450109/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ethylene-glycol-poisoning-with-oxalate-nephropathy-and-acute-kidney-injury-a-case-report-and-review-of-the-literature/450109.png","ImageObject",300,407,{"name":92,"@type":93},"Emma Wilson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why does ethylene glycol ingestion cause acute kidney injury?","Question",{"text":113,"@type":114},"Metabolism produces glycolate, acetaldehyde, and oxalate, which lead to tubular damage and oxalate crystal precipitation that obstructs tubules, resulting in acute kidney injury.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What findings supported the diagnosis in this case?",{"text":118,"@type":114},"Severe metabolic acidosis with elevated anion gap, acute kidney injury, hyperkalemia, and biopsy showing acute tubular necrosis with numerous oxalate crystals confirmed ethylene glycol poisoning with oxalate nephropathy.",{"name":120,"@type":111,"acceptedAnswer":121},"What treatments were used and what was the outcome?",{"text":122,"@type":114},"The patient received fluid resuscitation, bicarbonate therapy, alcohol administration, and hemodialysis/continuous renal replacement therapy. 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After being metabolized by ethanol dehydrogenase and aldehyde dehydrogenase, it can produce glycolate, acetaldehyde, and oxalate, leading to acute kidney injury. Renal failure is mainly caused by tubular damage induced by metabolites such as glyoxylate and oxalate, and may also be related to tubular obstruction caused by oxalate crystal precipitation. A 35-year-old Chinese man was brought to the emergency department in an unconscious state with a suspected history of EG ingestion. Laboratory examination revealed significant metabolic acidosis with elevated anion gap, acute kidney injury, and hyperkalemia, suggestive of possible EG poisoning. Renal biopsy revealed acute tubular necrosis, with numerous oxalate crystals forming in the tubules of the patient, confirming the diagnosis of EG poisoning with oxalate nephropathy. Treatment included fluid resuscitation, bicarbonate therapy, ethyl alcohol administration, and hemodialysis. After early and active treatment, the patient's consciousness recovered, acidosis improved significantly, and no further dialysis treatment was required.  \n1 | Introduction  \nEthylene glycol (EG) is a harmful alcohol found in various household and industrial products, and the ingestion of a small amount of EG may lead to death [1] . Because limited detection methods are available, the diagnosis of EG poisoning is usually based on clinical manifestations and nonspecific alternative laboratory study results [2] . Rapid identification and early treatment of EG poisoning, including the use of alcohol dehydrogenase (ADH) inhibitors and hemodialysis, are crucial. We report  \na suspected case of EG poisoning that resulted in an altered level of consciousness, oxalate nephropathy, and acute kidney injury.  \n2 | Case History and Examination  \nA 35-year-old Chinese man was brought to the emergency department in an unconscious state with a suspected history of EG ingestion because he was found with an open antifreeze bottle next to him. However, the ingested amount was unknown.  \n\n| The first two authors contributed equally to this article. |\n| --- |\n| This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.\u003Cbr>© 2026 The Author(s). Clinical Case Reports published by John Wiley & Sons Ltd. |\n\nClinical Case Reports, 2026; 14:e71774 1 of 4  \n[https://doi.org/10.1002/ccr3.71774](https://doi.org/10.1002/ccr3.71774)  \nKey Clinical Message  \nWe report a suspected case of EG poisoning that resulted inan altered level of consciousness, oxalate nephropathy, and acute kidney injury. This case highlights the complexity and severity of EG poisoning and emphasizes the need for early iden","cbCaipGs2sZbJKQF","https://ap.wps.com/l/cbCaipGs2sZbJKQF","pdf",884861,"English","# Abstract\n# 1 | Introduction\n# 2 | Case History and Examination\n# 3 | Differential Diagnosis, Investigations, and Treatment","[{\"question\":\"Why does ethylene glycol ingestion cause acute kidney injury?\",\"answer\":\"Metabolism produces glycolate, acetaldehyde, and oxalate, which lead to tubular damage and oxalate crystal precipitation that obstructs tubules, resulting in acute kidney injury.\"},{\"question\":\"What findings supported the diagnosis in this case?\",\"answer\":\"Severe metabolic acidosis with elevated anion gap, acute kidney injury, hyperkalemia, and biopsy showing acute tubular necrosis with numerous oxalate crystals confirmed ethylene glycol poisoning with oxalate nephropathy.\"},{\"question\":\"What treatments were used and what was the outcome?\",\"answer\":\"The patient received fluid resuscitation, bicarbonate therapy, alcohol administration, and hemodialysis/continuous renal replacement therapy. Early active treatment improved acidosis and recovered consciousness, and no further dialysis was required.\"}]","Ethylene Glycol Poisoning With Oxalate Nephropathy and Acute Kidney Injury - A Case Report and Review of the Literature | PDF",1790732100]