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This study developed a set of fact sheets for medical oncologists under the nationwide MONSTAR-SCREEN-2 project in Japan. A Genetic Specialist Committee drafted materials and external genetic experts reviewed them, followed by a one-year evaluation survey.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/establishment-of-a-comprehensive-set-of-fact-sheets-for-cancer-predisposition-genes-for-medical-oncologists-practicing-cancer-genome-profiling/374378/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/establishment-of-a-comprehensive-set-of-fact-sheets-for-cancer-predisposition-genes-for-medical-oncologists-practicing-cancer-genome-profiling/374378.png","ImageObject",300,407,{"name":92,"@type":93},"Margaret","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the purpose of the fact sheets in this study?","Question",{"text":112,"@type":113},"The fact sheets are designed to support medical oncologists in explaining cancer predisposition genes and CGP results, and to help connect patients to genetic services under MONSTAR-SCREEN-2.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were the fact sheets developed and reviewed?",{"text":117,"@type":113},"A Genetic Specialist Committee drafted the fact sheets, and external Genetic Experts reviewed the elements and contents before distribution.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the evaluation survey show about usefulness?",{"text":121,"@type":113},"In the evaluation survey, 83.3% of respondents rated the materials as “useful,” and the sections “What is genetic counseling” (100%) and “Lifetime risk” (94.4%) received particularly high ratings.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},374378,1790813116,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},137451207643,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","International Journal of Clinical Oncology (2025) 30:827–836  \n[https://doi.org/10.1007/s10147-025-02746-w](https://doi.org/10.1007/s10147-025-02746-w)  \nEstablishment of a comprehensive set of fact sheets for cancer predisposition genes for medical oncologists practicing cancer genome profiling  \nManami Matsukawa1,2 · Chikako Tomozawa1,2 · Yoshiaki Nakamura3,4 · Takao Fujisawa4,5 · Kaori Kimura2 · Yumie Hiraoka2 · Riu Yamashita6 · Shinji Kosugi7 · Akihiro Sakurai8 · Issei Imoto9 · Masakazu Nishigaki10 · Makoto Hirata1 · Takeshi Kuwata2 · Takayuki Yoshino3,11  \nReceived: 8 January 2025 / Accepted: 13 March 2025 / Published online: 4 April 2025 © The Author(s) 2025  \nAbstract  \nBackground Comprehensive genomic profiling (CGP) is widely performed worldwide, increasing opportunities for medical oncologists to explain cancer predisposition at the time of informed consent and return of results. How medical oncologists communicate about (suspected) cancer predisposition genes is a key factor in referring patients for consultation with genetic services. In this study, we developed a set of fact sheets on cancer predisposition genes to support medical oncologists in their practice under the nationwide cancer genome screening project MONSTAR-SCREEN-2 study in Japan.  \nMethods The Genetic Specialist Committee, comprising clinical geneticists, genetic counselors, bioinformaticians, and medical oncologists, drafted the fact sheet and external Genetic Experts reviewed its elements and contents. A fact sheet evaluation survey was conducted one year after the fact sheet was completed and distributed to medical oncologists at the National Cancer Center Hospital East.  \nResults The content of the fact sheet included an overview of diseases, inheritance, family impact, lifetime risk, and surveillance. In the evaluation survey, 83.3% of respondents rated it as “useful.” Notably, the sections “What is genetic counseling”(100%) and “Lifetime risk”(94.4%) received high ratings.  \nConclusion Our study suggests that a fact sheet developed by the Genetic Specialist Committee may help medical oncologists explain CGP results and connect patients to genetic services. It also functions as an educational resource that requires periodic updates and is in line with revisions to the guidelines.  \nKeywords Comprehensive genomic profiling · Cancer predisposition gene · Fact sheet · Genetic counseling  \n*  \n*  \n1  \n2  \n3  \n4  \n5  \nTakeshi Kuwata  \n[tkuwata@east.ncc.go.jp](tkuwata@east.ncc.go.jp)  \nTakayuki Yoshino  \n[tyoshino@east.ncc.go.jp](tyoshino@east.ncc.go.jp)  \nDepartment of Genetic Medicine and Services, National Cancer Center Hospital, Tokyo, Japan  \nDepartment of Genetic Medicine and Services, National Cancer Center Hospital East, Kashiwa, Japan  \nDepartment of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan  \nTranslational Research Support Office, National Cancer Center Hospital East, Kashiwa, Japan  \nDepartment of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan  \n6 Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan  \n7 Department of Genomic Medicine, Kyoto University School of Public Health, Kyoto, Japan  \n8 Department of Medical Genetics and Genomics, Sapporo Medical University School of Medicine, Sapporo, Japan  \n9 Aichi Cancer Center Research Institute, Nagoya, Japan  \n10 Department of Genetic Counseling, International University of Health and Welfare, Tokyo, Japan  \n11 Division for the Promotion of Drug and Diagnostic Development, National Cancer Center Hospital East, Kashiwa, Japan  \nIntroduction  \nComprehensive genomic profiling (CGP) is a standard method for cancer treatment worldwide [1] . Germline pathogenic variants (GPV) or presumed germline pathogenic variants (PGPV) can be detected in 4.1% – 17.5% of patients [2–9] . Patients with GPV/PGPV are referred to genetic ser","cbCaiuENAQKcPk44","https://ap.wps.com/l/cbCaiuENAQKcPk44","pdf",810722,"English","# Abstract\n# Background\n# Methods\n# Results\n# Conclusion\n# Keywords\n# Introduction\n## Comprehensive genomic profiling in cancer care\n## Germline variants and genetic service referral\n## Need for clear communication tools","[{\"question\":\"What is the purpose of the fact sheets in this study?\",\"answer\":\"The fact sheets are designed to support medical oncologists in explaining cancer predisposition genes and CGP results, and to help connect patients to genetic services under MONSTAR-SCREEN-2.\"},{\"question\":\"How were the fact sheets developed and reviewed?\",\"answer\":\"A Genetic Specialist Committee drafted the fact sheets, and external Genetic Experts reviewed the elements and contents before distribution.\"},{\"question\":\"What did the evaluation survey show about usefulness?\",\"answer\":\"In the evaluation survey, 83.3% of respondents rated the materials as “useful,” and the sections “What is genetic counseling” (100%) and “Lifetime risk” (94.4%) received particularly high ratings.\"}]","Establishment of a comprehensive set of fact sheets for cancer predisposition genes for medical oncologists practicing cancer genome profiling | PDF",1790201544,25]