[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-506420-105":59,"doc-detail-506420-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","establishing-reliable-selection-criteria-for-performing-fibrinolytic-therapy-in-patients-with-intracerebral-haemorrhage-based-on-prognostic-tools-article","Establishing reliable selection criteria for performing fibrinolytic therapy in patients with intracerebral haemorrhage based on prognostic tools - Article","","Minimally invasive surgery combined with fibrinolytic therapy offers a promising option for intracerebral haemorrhage (ICH), yet benefit depends on careful patient selection. The ICH score supports selection for fibrinolytic therapy except for ICH-4. This study tested whether additional prognostic tools can address this limitation by retrospectively analyzing a consecutive cohort treated with fibrinolytic therapy between 2010 and 2020.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/establishing-reliable-selection-criteria-for-performing-fibrinolytic-therapy-in-patients-with-intracerebral-haemorrhage-based-on-prognostic-tools-article/506420/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/establishing-reliable-selection-criteria-for-performing-fibrinolytic-therapy-in-patients-with-intracerebral-haemorrhage-based-on-prognostic-tools-article/506420.png","ImageObject",300,407,{"name":92,"@type":93},"Kurz","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-10-05",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is patient selection important for fibrinolytic therapy in intracerebral haemorrhage?","Question",{"text":112,"@type":113},"Not every ICH patient benefits from fibrinolytic therapy, so meticulous selection is required to avoid ineffective treatment.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which prognostic tools were evaluated in this study?",{"text":117,"@type":113},"The study calculated APACHE II, ICH-GS, ICHFUNC, and the ICH score for each patient and compared their discrimination using ROC-analysis.",{"name":119,"@type":110,"acceptedAnswer":120},"What was the main finding about the APACHE II score?",{"text":121,"@type":113},"APACHE II added to the ICH score 4 increased discrimination for in-hospital mortality and functional outcome, supporting more precise patient selection.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},506420,1793122757,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},2336478945635,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Establishing reliable selection criteria for performing fibrinolytic therapy in patients with intracerebral haemorrhage based on prognostic tools  \nRegina Schwiddessen, Christian von der Brelie, Dorothee Mielke, Veit Rohde, Vesna Malinova  \nAngaben zur Veröffentlichung / Publication details:  \nSchwiddessen, Regina, Christian von der Brelie, Dorothee Mielke, Veit Rohde, and Vesna Malinova.  \n2024.“Establishing reliable selection criteria for performing fibrinolytic therapy in patients with intracerebral haemorrhage based on prognostic tools.” Journal of Stroke and Cerebrovascular Diseases 33 (8): 107804 . [https://doi.org/10.1016/j.jstrokecerebrovasdis.2024.107804](https://doi.org/10.1016/j.jstrokecerebrovasdis.2024.107804) .  \nNutzungsbedingungen / Terms of use: CC BY-NC 4.0  \nDieses Dokument wird unter folgenden Bedingungen zur Verfügung gestellt: / This document is made available under these conditions:  \nCC-BY-NC 4.0: Creative Commons: Namensnennung-Nicht kommerziell  \nWeitere Informationen finden Sie unter: / For more information see:  \n[https://creativecommons.org/licenses/by-nc/4.0/deed.de](https://creativecommons.org/licenses/by-nc/4.0/deed.de)  \nJournal of Stroke and Cerebrovascular Diseases 33 (2024) 107804  \nContents lists available at ScienceDirect  \nJournal of Stroke and Cerebrovascular Diseases  \njournal [homepage:](homepage: www.elsevier.com/locate/jstroke)[ www.elsevier.com/locate/jstroke](homepage: www.elsevier.com/locate/jstroke)  \n| Establishing reliable selection criteria for performing fibrinolytic therapy inpatients with intracerebral haemorrhage based on prognostic tools\u003Cbr>Regina Schwiddessena, Christian von der Brelie, MDa, b, Dorothee Mielke, MDa, c, Veit Rohde, MDa, Vesna Malinova, MDa, *\u003Cbr>a Department of Neurosurgery, University Medical Center, G¨ottingen, Germany b Department of Neurosurgery and Spine Surgery, Johanniter-Kliniken Bonn, Germany c Department of Neurosurgery, University Medical Center Augsburg, Augsburg, Germany |  |  |\n| --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |\n| Keywords:\u003Cbr>Intracerebral hemorrhage Fibrinolytic therapy Prognostic tools |  | Objectives: Minimally invasive surgery combined with fibrinolytic therapy is a promising treatment option for patients with intracerebral haemorrhage (ICH), but a meticulous patient selection is required, because not every patient benefits from it. The ICH score facilitates a reliable patient selection for fibrinolytic therapy except for ICH-4. This study evaluated whether an additional use of other prognostic tools can overcome this limitation. Materials and Methods: A consecutive ICH patient cohort treated with fibrinolytic therapy between 2010 and 2020 was retrospectively analysed. The following prognostic tools were calculated: APACHE II, ICH-GS, ICHFUNC, and ICH score. The discrimination power of every score was determined by ROC-analysis. Primary outcome parameters regarding the benefit of fibrinolytic therapy were the in-hospital mortality and a poor outcome defined as modified Rankin scale (mRS) > 4.\u003Cbr>Results: A total of 280 patients with a median age of 72 years were included. The mortality rates according to the ICH score were ICH-0 = 0 %(0/0), ICH-1 = 0 %(0/22), ICH-2 = 7.1 %(5/70), ICH-3 = 17.3 %(19/110), ICH-4 = 67.2 %(45/67), ICH-5 = 100 %(11/11). The APACHE II showed the best discrimination power for in-hospital mortality (AUC = 0.87, p \u003C 0.0001) and for poor outcome (AUC = 0.79, p \u003C 0.0001). In the subgroup with ICH- 4, APACHE II with a cut-off of 24.5 showed a good discriminating power for in-hospital mortality (AUC = 0.83, p \u003C 0.001) and for poor outcome (AUC = 0.87, p \u003C 0.001).\u003Cbr>Conclusions: An additional application of APACHE II score increases the discriminating power of ICH score 4 enabling a more precise appraisal of in-hospital mortality and of functional outcome, which could support the patient selection for fibrinolytic therapy. |\n\nIntroduction  \nSpontaneous intracerebral hemorrhage (ICH) is","cbCaiohhNXgjK1Tx","https://ap.wps.com/l/cbCaiohhNXgjK1Tx","pdf",1899327,"English","# Introduction\n## Objectives and rationale\n# Materials and Methods\n## Prognostic tools and outcomes\n# Results\n## Mortality and discrimination performance\n# Conclusions","[{\"question\":\"Why is patient selection important for fibrinolytic therapy in intracerebral haemorrhage?\",\"answer\":\"Not every ICH patient benefits from fibrinolytic therapy, so meticulous selection is required to avoid ineffective treatment.\"},{\"question\":\"Which prognostic tools were evaluated in this study?\",\"answer\":\"The study calculated APACHE II, ICH-GS, ICHFUNC, and the ICH score for each patient and compared their discrimination using ROC-analysis.\"},{\"question\":\"What was the main finding about the APACHE II score?\",\"answer\":\"APACHE II added to the ICH score 4 increased discrimination for in-hospital mortality and functional outcome, supporting more precise patient selection.\"}]","Establishing reliable selection criteria for performing fibrinolytic therapy in patients with intracerebral haemorrhage based on prognostic tools - Article | PDF",1791165163]