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This cross-sectional study compared esophagogastroduodenal findings in 340 IPMN patients with age- and gender-matched controls without known IPMNs who underwent esophagogastroduodenoscopies (EGDs) for similar reasons. Gastric and esophageal cancer, Barrett's esophagus, neuroendocrine tumors, GISTs, gastric adenomas, and ampullary tumors were assessed. IPMN patients showed a higher-than-expected gastric cancer incidence and a similar overall rate of other EGD findings.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/esophagogastroduodenal-findings-in-patients-with-intraductal-papillary-mucinous-neoplasms-study-results/380110/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/esophagogastroduodenal-findings-in-patients-with-intraductal-papillary-mucinous-neoplasms-study-results/380110.png","ImageObject",300,407,{"name":92,"@type":93},"Mia  ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the study design and main comparison in this research?","Question",{"text":113,"@type":114},"A cross-sectional study compared esophagogastroduodenal findings from 340 IPMN patients with findings from age- and gender-matched controls without known IPMNs, based on EGD results for similar clinical reasons.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which specific conditions were evaluated during EGD?",{"text":118,"@type":114},"The study assessed gastric and esophageal cancer, Barrett's esophagus, neuroendocrine tumors, gastrointestinal stromal tumors, gastric adenomas, and ampullary tumors.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the key findings about gastric and esophageal cancer?",{"text":122,"@type":114},"Among IPMN patients, gastric cancer occurred in 4/340 (1.2%) and esophageal cancer in 1/340 (0.3%). 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Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms. Diagnostics 2023, 13, 2127. [https://doi.org//](https://doi.org//)[ ](https://doi.org//)[10.3390diagnostics13122127](10.3390diagnostics13122127)  \n1 The Kamila Gonczarowski Institute of Gastroenterology and Liver Diseases, Shamir (Assaf Harofeh) Medical Center, Zerifin 703000, Israel; [danazelnik@gmail.com](danazelnik@gmail.com)  \n2 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, Israel  \n3 Department of Gastroenterology, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel  \n4 Department of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel  \n* [Correspondence: benamidana@gmail.com](Correspondence: benamidana@gmail.com); Tel.: +972-544305007  \nAbstract: The association between intraductal papillary mucinous neoplasms (IPMNs) and extrapancreatic malignancies is controversial. This cross-sectional study compared esophagogastroduodenal findings in 340 IPMN patients to those of age-and gender-matched controls without known IPMNs who underwent esophagogastroduodenoscopies (EGDs) for similar clinical reasons. The presence of gastric and esophageal cancer, Barrett's esophagus, neuroendocrine tumors (NETs), gastrointestinal stromal tumors (GISTs), gastric adenomas, and ampullary tumors was assessed. The results showed that 4/340 (1.2%) of the IPMN patients had gastric cancer and 1/340 (0.3%) had esophageal cancer. The matched control group had a similar incidence of gastric cancer (5/340) (1.5%), with no esophageal cancer cases (p > 0.999) . The overall incidence of other esophagogastroduodenal conditions did not significantly differ between the IPMN patients and the controls. However, the incidence of gastric cancer in the IPMN patients was higher than expected based on national cancer registry data (standardized incidence ratio of 31.39; p \u003C 0.001; CI 8.38–78.76) . In conclusion, IPMN patients have a significantly higher incidence of gastric cancer compared to the general population. However, the incidence of esophagogastroduodenal findings, including gastric and esophageal cancer, is similar between IPMN patients and those who undergo an EGD for similar clinical indications. Further research is needed to determine optimal surveillance strategies for IPMN patients regarding their risk of developing gastric cancer.  \nKeywords: intraductal papillary mucinous neoplasms (IPMNs); gastric cancer; esophageal cancer  \n1. Introduction  \nAcademic Editor: Ervin Toth  \nReceived: 24 May 2023  \nRevised: 16 June 2023  \nAccepted: 19 June 2023  \nPublished: 20 June 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nCystic lesions of the pancreas are a common incidental finding in abdominal imaging. In recent years, their prevalence among asymptomatic patients has been on the rise, mainly due to improvements in imaging techniques. Studies have estimated that cystic lesions of the pancreas are present in approximately 2.4% to 13.5% of asymptomatic populations [1] . It is important to note that the most common pancreatic cysts encountered are intraductal papillary mucinous neoplasms (IPMNs) [1] . IPMNs are characterized by the intraductal growth of mucin-producing cells, and they can be classified into main duct, side duct (branch duct), or mixe","cbCaibncHSEO9paJ","https://ap.wps.com/l/cbCaibncHSEO9paJ","pdf",2891624,"English","# Abstract\n# Introduction","[{\"question\":\"What was the study design and main comparison in this research?\",\"answer\":\"A cross-sectional study compared esophagogastroduodenal findings from 340 IPMN patients with findings from age- and gender-matched controls without known IPMNs, based on EGD results for similar clinical reasons.\"},{\"question\":\"Which specific conditions were evaluated during EGD?\",\"answer\":\"The study assessed gastric and esophageal cancer, Barrett's esophagus, neuroendocrine tumors, gastrointestinal stromal tumors, gastric adenomas, and ampullary tumors.\"},{\"question\":\"What were the key findings about gastric and esophageal cancer?\",\"answer\":\"Among IPMN patients, gastric cancer occurred in 4/340 (1.2%) and esophageal cancer in 1/340 (0.3%). Controls had a similar gastric cancer incidence (5/340, 1.5%) with no esophageal cancer cases, but the gastric cancer rate in IPMN patients was higher than expected versus national registry data.\"}]","Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms - Study Results | PDF",1790238778,28]