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Patients with MEC were older and had lower cTNM stage, with many showing Barrett’s esophagus, hiatus hernia, esophagitis, or ulceration; cautious follow-up is suggested.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/esophageal-cancers-missed-at-upper-endoscopy-in-central-norway-2004-to-2021-a-population-based-study/332351/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/esophageal-cancers-missed-at-upper-endoscopy-in-central-norway-2004-to-2021-a-population-based-study/332351.png","ImageObject",300,407,{"name":42,"@type":43},"Ezra","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How were missed esophageal cancers (MEC) defined in the study?","Question",{"text":63,"@type":64},"MEC were defined as esophageal cancers diagnosed 6–36 months after a nondiagnostic upper endoscopy.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Did the MEC rate change over the study period?",{"text":68,"@type":64},"Annual numbers of both esophageal cancer and MEC increased, while the MEC rate did not change significantly.",{"name":70,"@type":61,"acceptedAnswer":71},"What endoscopic findings were common among patients with MEC?",{"text":72,"@type":64},"High proportions of MEC patients had Barrett’s esophagus, hiatus hernia, esophagitis, and ulceration.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332351,1790013688,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":123,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Straum etal. BMCGastroenterology (2024) 24:279  \n[https://doi.org/10.1186/s12876-024-03371-z](https://doi.org/10.1186/s12876-024-03371-z)  \nBMC Gastroenterology  \nRESEARCH Open Access  \nEsophageal cancers missed at upper   \nendoscopy in Central Norway 2004 to 2021 – A population-based study  \nSynne Straum 1†, Karoline Wol lan 1†, Lars Cato Rekstad2 and Reidar Fossmark 1,3*  \nAbstract  \nIntroduction The incidence of esophageal cancers is increasing in many Western countries and the rate of missed esophageal cancers (MEC) at upper endoscopy is of concern. We aimed to calculate the MEC rate and identify factors associated with MEC.  \nMethods This was a retrospective population-based cohort study including 613 patients diagnosed with esophageal cancer in Central Norway 2004–2021. MEC was defined as esophageal cancer diagnosed 6–36 months after a nondiagnostic upper endoscopy. Patient characteristics, tumor localization, histological type and cTNM stage were recorded. Symptoms, endoscopic findings, use of sedation and endoscopists experience at the endoscopy prior to esophageal cancer diagnosis and at the time of diagnosis were recorded. The association between these factors and MEC was assessed.  \nResults Forty-nine (8 . 0%) of 613 cancers were MEC. There was a significant increase in annual numbers of esophageal cancer (p \u003C 0. 001) as well as of MEC (p = 0 . 009), but MEC rate did not change significantly (p = 0 . 382) . The median time from prior upper endoscopy to MEC diagnosis was 22.9 (12 .1–28. 6) months. MEC patients were older and were diagnosed with disease with a lower cTNM stage and cT category than non-missed cancers, whereas tumor localization and histological type were similar between the groups. The use of sedation or endoscopist experience did not differ between the endoscopy prior to esophageal cancer diagnosis and at the time of diagnosis. High proportions of MEC patients had Barrett’s esophagus (n = 25, 51 . 0%), hiatus hernia (n = 26, 53 . 1%), esophagitis (n = 10, 20.4%) or ulceration (n = 4, 8 . 2%) . Significant proportions of MECs were diagnosed after inappropriate follow-up of endoscopic Barrett’s esophagus, histological dysplasia or ulcerations.  \nConclusions The annual number of MEC increased during the study period, while the MEC rate remained unchanged. Endoscopic findings related to gastroesophageal reflux disease such as esophagitis and Barrett’s esophagus were identified in a high proportion of patients with subsequent MECs. Cautious follow-up of these patients could potentially reduce MEC-rate.  \nKeywords Esophageal cancer, Quality in endoscopy, Epidemiology, Barrett’s esophagus  \n†Synne Straum and Karoline Wol lan contributed equally to this work.  \n*Correspondence:  \nReidar Fossmark [reidar.fossmark@ntnu. no](reidar.fossmark@ntnu. no)  \n1Department of Clinical and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU, Trondheim, Norway  \n2Department of Gastrointestinal Surgery, St Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway  \n3Department of Gastroenterology, St Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, v","cbCaihmRTzVgL52E","https://ap.wps.com/l/cbCaihmRTzVgL52E","pdf",1235645,"English","# Abstract\n# Introduction\n# Methods\n# Results\n# Conclusions","[{\"question\":\"How were missed esophageal cancers (MEC) defined in the study?\",\"answer\":\"MEC were defined as esophageal cancers diagnosed 6–36 months after a nondiagnostic upper endoscopy.\"},{\"question\":\"Did the MEC rate change over the study period?\",\"answer\":\"Annual numbers of both esophageal cancer and MEC increased, while the MEC rate did not change significantly.\"},{\"question\":\"What endoscopic findings were common among patients with MEC?\",\"answer\":\"High proportions of MEC patients had Barrett’s esophagus, hiatus hernia, esophagitis, and ulceration.\"}]","Esophageal cancers missed at upper endoscopy in Central Norway 2004 to 2021 - A population-based study | PDF",1789997817,25]