[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-429716-105":59,"doc-detail-429716-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","eruptive-process-in-children-with-osteogenesis-imperfecta","Eruptive Process in Children with Osteogenesis Imperfecta","","Osteogenesis imperfecta (OI) is a hereditary disorder marked by bone fragility and skeletal abnormalities. In children with OI, bisphosphonates (BPs) increase bone density by inhibiting osteoclast-mediated resorption, potentially affecting eruptive processes. This study evaluates dental development of permanent teeth, resorption of primary teeth, and alveolar eruption of the first permanent molar, comparing 34 BP-medicated OI children and 367 healthy controls. Results show delayed dental development, delayed exfoliation and root resorption, and reduced timing of alveolar eruption, including greater delay with higher cumulative BP dose.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/eruptive-process-in-children-with-osteogenesis-imperfecta/429716/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/eruptive-process-in-children-with-osteogenesis-imperfecta/429716.png","ImageObject",300,407,{"name":92,"@type":93},"Asher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What dental aspects were evaluated in children with osteogenesis imperfecta treated with bisphosphonates?","Question",{"text":112,"@type":113},"The study assessed dental development of permanent dentition, resorption of temporary (primary) dentition, and alveolar eruption of the first permanent molar.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were comparisons between the study group and controls performed?",{"text":117,"@type":113},"A total of 34 panoramic radiographs from BP-medicated OI children were compared with 367 radiographs from healthy children. Statistical comparisons used the Mann–Whitney U test with p \u003C 0.05 as significance.",{"name":119,"@type":110,"acceptedAnswer":120},"What main delays were reported in the OI group receiving bisphosphonates?",{"text":121,"@type":113},"Delayed dental development, delayed exfoliation of primary teeth, delayed root resorption, and delayed alveolar eruption of the first permanent molar were reported. Greater alveolar-eruption delay was observed when cumulative bisphosphonate dose exceeded 2000.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},429716,1790741905,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},687197207639,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Calcified Tissue International (2025) 116:37  \n[https://doi.org/10.1007/s00223-025-01345-1](https://doi.org/10.1007/s00223-025-01345-1)  \nEruptive Process in Children with Osteogenesis Imperfecta  \nClara Sandibel Garcete Delvalle1 · M. Joaquín De Nova García1 · María Rosa Mourelle Martínez1  \nReceived: 3 November 2024 / Accepted: 13 January 2025 / Published online: 7 February 2025 © The Author(s) 2026  \nAbstract  \nOsteogenesis imperfecta (OI) is a hereditary disorder characterized by bone fragility and skeletal abnormalities. The administration of bisphosphonates (BPs) in children with OI increases bone density. This antiresorptive inhibits osteoclast action, thus altering physiological processes, in which osteoclasts play important roles, such as the eruptive process. The aim of this investigation was to study the eruptive process (dental development of permanent dentition, resorption of temporary dentition, and alveolar eruption of the first permanent molar) in children with OI medicated with BPs and to compare the results with those of a control group. In total, 34 panoramic radiographs of children with OI [mean chronological age of 8.43 (± 1.77)] who were medicated with BPs for a period of one year or more were studied and 367 panoramic radiographs of healthy children [mean chronological age of 9.19 (± 1.62)] were used as controls. The Demirjian method was used to study the dental development of the seven permanent teeth in the third quadrant. Alveolar eruption of the first permanent molar was considered when perforation of the alveolar bone was produced. The Haavikko method was used to study the root resorption of the five primary teeth in the third quadrant, and software (PixelStick®) was used to measure the lengths of themesial and distal roots of the primary molars. The cumulative dose of BPs was obtained by mathematically calculating the total dosage received (mg)/weight (kg) and multiplying the relative potency of the medication. The Mann‒Whitney U test was used for comparisons, and p \u003C 0.05 indicated statistical significance. A delay of 0.95 points in dental development and delayed exfoliation of primary dentition between 1.31 and 1.66 years were described in the study group. A root resorption delay of 11.8% was described among the 5 primary teeth of 23.3% among the single-rooted teeth and of 5.6% among the two-rooted teeth in children with OI medicated with BFs (p \u003C 0.05). Delayed alveolar eruption of the first permanent molar at 0.31 years of age was found in children with OI medicated with BFs. We detected delayed tooth development at one stage of maturation in the study group, which was clinically imperceptible. The dental age (≤ 0.55 years) was greater than the chronological age in both groups. We also reported delayed exfoliation of the primary dentition (from 1.31 to 1.66 years), delayed root resorption of the primary dentition (11.8%), and delayed (from 1 mm to 1.25 mm) root resorption of the primary molars in the study group. Although the degree of dental development of the first permanent molar was similar between the two groups, we found delayed (0.31 years) alveolar eruption in the study group and a greater delay (0.44 years) in children whose cumulative dose ofbisphosphonates exceeded 2000.  \nKeywords Alveolar eruption · Osteogenesis Imperfecta · Bisphosphonates · Root resorption · Dental exfoliation · Dental development · Permanent dentition · Primary dentition · Panoramic radiograph  \nAbbreviations  \nOI Osteogenesis Imperfecta  \nBPs Bisphosphonates  \nRR Root Resorption  \nDD Dental Development  \n* Clara Sandibel Garcete Delvalle[cgarcete@ucm.es](cgarcete@ucm.es)  \n1 Faculty of Dentistry, Complutense University of Madrid, Madrid, Spain  \nCDBPs Cumulate dose ofbiphosphonates  \nDI Dentinogenesis Imperfecta  \nIntroduction  \nOsteogenesis imperfecta (OI), or brittle bone disease, is a group of heterogeneous disorders characterized by bone fragility, multiple fractures, skeletal deformity, short stature, low ","cbCaisrijtF4AeCS","https://ap.wps.com/l/cbCaisrijtF4AeCS","pdf",540590,"English","# Abstract\n# Introduction\n## Background on osteogenesis imperfecta (OI)\n## Orofacial alterations and eruptive delays\n## Role of bisphosphonates and osteoclasts in the eruptive process","[{\"question\":\"What dental aspects were evaluated in children with osteogenesis imperfecta treated with bisphosphonates?\",\"answer\":\"The study assessed dental development of permanent dentition, resorption of temporary (primary) dentition, and alveolar eruption of the first permanent molar.\"},{\"question\":\"How were comparisons between the study group and controls performed?\",\"answer\":\"A total of 34 panoramic radiographs from BP-medicated OI children were compared with 367 radiographs from healthy children. Statistical comparisons used the Mann–Whitney U test with p \\u003c 0.05 as significance.\"},{\"question\":\"What main delays were reported in the OI group receiving bisphosphonates?\",\"answer\":\"Delayed dental development, delayed exfoliation of primary teeth, delayed root resorption, and delayed alveolar eruption of the first permanent molar were reported. Greater alveolar-eruption delay was observed when cumulative bisphosphonate dose exceeded 2000.\"}]","Eruptive Process in Children with Osteogenesis Imperfecta | PDF",1790650931,23]