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Evidence from recent decades shows it modulates cancer cell fate by coordinating cell-cycle control, survival, and regulated cell death pathways. Mechanistic reports highlight reshaping of oncogenic signaling networks, including PI3K/Akt/mTOR, leading to reduced proliferation and altered resistance. Findings also describe checkpoint cell-cycle arrest and apoptosis via mitochondrial and death-receptor routes through BCL-2 balance, caspase activation, and mitochondrial disruption, plus dose-dependent redox and ferroptosis and inflammation-related tumor progression effects. Nanocarrier delivery and combination strategies support translational potential despite solubility and bioavailability challenges.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/eriodictyol-in-cancer-therapy-reviewing-mechanistic-insightsand-translational-opportunities/355478/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/eriodictyol-in-cancer-therapy-reviewing-mechanistic-insightsand-translational-opportunities/355478.png","ImageObject",300,407,{"name":92,"@type":93},"Aria Callaghan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does eriodictyol influence cancer cell fate according to the review?","Question",{"text":112,"@type":113},"It coordinates modulation of cell-cycle control, survival, and regulated cell death pathways, reshaping oncogenic signaling networks such as PI3K/Akt/mTOR to restrict proliferation and affect resistance.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What apoptotic mechanisms are reported for eriodictyol?",{"text":117,"@type":113},"The review reports cell-cycle arrest at key checkpoints and activation of mitochondrial- and death-receptor-mediated apoptotic pathways, linked to disruption of BCL-2 family balance, caspase engagement, and mitochondrial destabilization.",{"name":119,"@type":110,"acceptedAnswer":120},"What translational approaches are discussed to address eriodictyol’s limitations?",{"text":121,"@type":113},"The review highlights nanocarrier-based delivery and balanced combination strategies aimed at overcoming solubility and bioavailability challenges while enabling precise therapeutic applications.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},355478,1791175952,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962084926284,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Review  \nEriodictyol in Cancer Therapy: Reviewing Mechanistic Insightsand Translational Opportunities  \nSohail Mumtaz 1, *, Juie Nahushkumar Rana 2 and Kainat Gul 3  \nAcademic Editors: Bernhard Biersack and Alessandro Canella  \nReceived: 19 January 2026  \nRevised: 17 February 2026  \nAccepted: 4 March 2026  \nPublished: 24 March 2026  \nCopyright: © 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Department of Chemical and Biological Engineering, Gachon University, 1342 Seongnamdaero, Sujeong-gu, Seongnam-si 13120, Republic of Korea  \n2 Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA  \n3 Department of Botany, Hazara University, Mansehra 21300, Pakistan  \n* Correspondence: [sohail38@gachon.ac.kr](sohail38@gachon.ac.kr); Tel.: +82-010-6559-6861; Fax: +82-2-940-5664  \nAbstract  \nEriodictyol, a naturally occurring flavanone, has appeared as a biologically versatile compound with increasing relevance in biomedical research, especially in cancers. Evidence over the past few decades indicates that eriodictyol influences cancer cell fate through coordinated modulation of cell-cycle control, survival, and regulated cell death pathways. Eriodictyol appears to reshape oncogenic signaling networks, including PI3K/Akt/mTOR and associated kinase cascades, thereby restricting proliferative capacity and lowering resistance thresholds. Studies consistently report cell-cycle arrest at critical checkpoints, accompanied by activation of both mitochondrial-and death-receptor-mediated apoptotic pathways through disruption of BCL-2 family balance, caspase engagement, and mitochondrial destabilization. Furthermore, eriodictyol alters intracellular redox dynamics ina dose-dependent manner, selectively sensitizing cancer cells to oxidative and metabolic stress. More recent findings extend its significance to inflammation-driven tumor progression and to the regulation of ferroptosis. Beyond intrinsic pharmacological activity, advances in nanocarrier-based delivery and balanced combination strategies have started to address critical challenges and limitations regarding solubility and bioavailability, while allowing precise therapeutic applications. In this review, we have discussed the plausible mechanisms, experimental evidence, and translational insights of eriodictyol as a systems-level modulator of cancer biology. We also outlined research priorities essential for progressing its clinical relevance as future perspectives.  \nKeywords: eriodictyol; cancer signaling pathways; nanomedicine and drug delivery; apoptosis and ferroptosis; combination therapy  \n1. Introduction  \nNatural products derived from plants have long been recognized as an important source of bioactive molecules investigated for their broad medical relevance across human diseases [1–4] . Owing to their chemical diversity and biological versatility, plant-derived compounds have been explored in multiple disease areas, including cancer, metabolic disorders, inflammatory conditions, and neurological diseases [5–8] . Recent advancesin experimental biology and computational methodologies have further enabled the systematic investigation of natural compounds within complex disease-associated biological networks [4] . In parallel, continuous progress in biomedical research technologies—such as molecular profiling and spectroscopic approaches—has contributed to improved disease  \ncharacterization and diagnostic exploration [9,10], while genomic analyses have enhanced understanding of disease-associated genetic alterations [11,12] . Moreover, growing insights into tumor heterogeneity, immune microenvironment interactions, and immunotherapyrelated strategies have highlighted the importance of immune regulation in cancer research [13,14] . In addition to pharmacological agent","cbCailAORIyKMQlm","https://ap.wps.com/l/cbCailAORIyKMQlm","pdf",8821178,34,"English","# Abstract\n# Keywords\n# Introduction","[{\"question\":\"How does eriodictyol influence cancer cell fate according to the review?\",\"answer\":\"It coordinates modulation of cell-cycle control, survival, and regulated cell death pathways, reshaping oncogenic signaling networks such as PI3K/Akt/mTOR to restrict proliferation and affect resistance.\"},{\"question\":\"What apoptotic mechanisms are reported for eriodictyol?\",\"answer\":\"The review reports cell-cycle arrest at key checkpoints and activation of mitochondrial- and death-receptor-mediated apoptotic pathways, linked to disruption of BCL-2 family balance, caspase engagement, and mitochondrial destabilization.\"},{\"question\":\"What translational approaches are discussed to address eriodictyol’s limitations?\",\"answer\":\"The review highlights nanocarrier-based delivery and balanced combination strategies aimed at overcoming solubility and bioavailability challenges while enabling precise therapeutic applications.\"}]","Eriodictyol in Cancer Therapy - Reviewing Mechanistic Insightsand Translational Opportunities | PDF",1790119274,86]