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Findings summarize observed sex and age tendencies, most common anatomic sites, and the frequency of key entities such as pleomorphic adenoma and mucoepidermoid carcinoma, emphasizing treatment and prognosis implications for pediatric 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is the main focus of this review?","Question",{"text":63,"@type":64},"The review provides a comprehensive overview of primary epithelial salivary gland neoplasms in pediatric patients, emphasizing demographic, clinical, and histopathological characteristics and their treatment implications.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which tumors and sites are most commonly reported in pediatric patients?",{"text":68,"@type":64},"The parotid gland is the most commonly affected site, and pleomorphic adenoma and mucoepidermoid carcinoma are the most frequently observed entities.",{"name":70,"@type":61,"acceptedAnswer":71},"How do pediatric salivary gland tumor outcomes generally compare with adults?",{"text":72,"@type":64},"The review highlights distinct clinical features and prognostic outcomes in pediatric patients compared with adults, noting that although tumors are rare, overall prognosis is generally favorable and clinicians should remain vigilant when evaluating nodular 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Salivary gland tumors in pediatric patients  \nJournal section: Oral Medicine and Pathology doi:10.4317/medoral.26983  \nPublication Types: Review  \nEpithelial salivary gland neoplasms in pediatric patients: A comprehensive review  \nMaria Eduarda Pérez-de-Oliveira 1, Sebastião Silvério de Sousa-Neto 2, Pablo Agustin Vargas 3  \n1 DDS, MSc, PhD, Department of Clinical and Preventive Dentistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil 2 DDS, MSc, Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas, Piracicaba, São Paulo, Brazil 3 DDS, PhD, FRCPath, Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas, Piracicaba, São Paulo, Brazil  \nCorrespondence:  \nDepartamento de Diagnóstico Oral Área de Patologia Oral  \nFaculdade de Odontologia de Piracicaba Universidade Estadual de Campinas Av. Limeira, 901, Postal code: 13.414-903 Piracicaba, São Paulo (SP), Brasil [pavargas@unicamp.br](pavargas@unicamp.br)  \n[Received: 14/10/2024](Received: 14/10/2024)  \n[Accepted: 17/03/2025](Accepted: 17/03/2025)  \nMaria Eduarda Pérez-de-Oliveira, Sebastião Silvério de Sousa-Neto, Pablo Agustin Vargas. Epithelial salivary gland neoplasms in pediatric patients: A comprehensive review. Med Oral Patol Oral Cir Bucal. 2025 May 1;30 (3):e440-5.  \nArticle Number:26983 [http://www.medicinaoral.com/](http://www.medicinaoral.com/)  \n© Medicina Oral S. L. C.I.F. B 96689336-pISSN 1698-4447-eISSN: 1698-6946  \neMail: [medicina@medicinaoral.com](medicina@medicinaoral.com)  \nIndexed in:  \nScience Citation Index Expanded  \nJournal Citation Reports  \nIndex Medicus, MEDLINE, PubMed Scopus, Embase and Emcare Indice Médico Español  \nAbstract  \nBackground: Salivary gland tumors (SGTs) are a rare group of neoplasms in pediatric patients, characterized by diverse histological subtypes and distinct biological behaviors. This manuscript aims to provide a comprehensive overview of the demographic, clinical, and histopathological characteristics of SGTs in this population, with the goal of enhancing understanding of their presentation and implications for treatment.  \nMaterial and Methods: An updated descriptive literature review was performed to identify studies reporting the clinicopathological features of epithelial SGTs in pediatric patients.  \nResults: SGTs in pediatric patients are slightly more prevalent in females and typically arise during the second decade of life. The parotid gland is the most commonly affected site for both benign and malignant tumors, which usually present as an asymptomatic mass. Pleomorphic adenoma and mucoepidermoid carcinoma are the most frequently observed entities. Surgical intervention remains the primary treatment modality, and the overall prognosis is generally favorable.  \nConclusions: This review highlights that SGTs in pediatric patients present distinct clinical features and prognostic outcomes compared to adults. Although they are rare in this age group, clinicians should remain vigilant to these neoplasms when assessing nodular masses in both major and minor salivary glands.  \nKey words: Salivary gland tumors, pediatric, mucoepidermoid carcinoma, pleomorphic adenoma.  \nIntroduction  \nSalivary gland tumors (SGTs) are a group of lesions with a wide range of histological subtypes and distinct biological behaviors representing a diagnostic and therapeutic challenges for both pathologists and surgeons (1). The incidence of SGTs varies by country, but they are generally rare, with an annual incidence of approxi-  \nmately 2.5 to 3.0 per 100,000 people (2). Malignant SGTs comprise 2-6% of all head and neck cancers with an annual worldwide incidence of 0.07% corresponding to 54,799 cases per year (3).  \nOverall, SGTs have a slight female predilection with a peak of incidence between the fourth to seventh decades of life. Parotid gland is generally the most affected site,  \nfollowed by minor salivary glands,","cbCaiq3Pxzy6s2zO","https://ap.wps.com/l/cbCaiq3Pxzy6s2zO","pdf",1935902,"English","# Abstract\n## Background\n## Material and Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What is the main focus of this review?\",\"answer\":\"The review provides a comprehensive overview of primary epithelial salivary gland neoplasms in pediatric patients, emphasizing demographic, clinical, and histopathological characteristics and their treatment implications.\"},{\"question\":\"Which tumors and sites are most commonly reported in pediatric patients?\",\"answer\":\"The parotid gland is the most commonly affected site, and pleomorphic adenoma and mucoepidermoid carcinoma are the most frequently observed entities.\"},{\"question\":\"How do pediatric salivary gland tumor outcomes generally compare with adults?\",\"answer\":\"The review highlights distinct clinical features and prognostic outcomes in pediatric patients compared with adults, noting that although tumors are rare, overall prognosis is generally favorable and clinicians should remain vigilant when evaluating nodular masses.\"}]","Epithelial salivary gland neoplasms in pediatric patients - A comprehensive review | PDF",1790197713,15]