[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-384289-105":59,"doc-detail-384289-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","epigenome-driven-strategies-for-personalized-cancer-immunotherapy-review","Epigenome-Driven Strategies for Personalized Cancer Immunotherapy - review","","Fighting cancer remains a defining scientific challenge in the 21st century, and immunotherapy advances have transformed treatment, remission, and cure. This review explains how epigenetic phenomena and epigenomic changes shape tumor biology and enable epigenetic modulation of immune responses. It covers mechanisms such as DNA methylation, histone modifications, and non-coding RNA regulation, highlighting biomarkers like PD-1 and PD-L1 and emerging epigenetic drug targets, while emphasizing future personalized immunotherapy.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/epigenome-driven-strategies-for-personalized-cancer-immunotherapy-review/384289/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/epigenome-driven-strategies-for-personalized-cancer-immunotherapy-review/384289.png","ImageObject",300,407,{"name":92,"@type":93},"Blitz","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-25","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",16,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How does epigenetics influence cancer development?","Question",{"text":113,"@type":114},"Epigenetics changes gene expression without altering DNA sequence. It includes processes such as DNA methylation that can silence tumor suppressor genes, enabling uncontrolled cell division.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What epigenomic mechanisms are discussed in relation to immunotherapy?",{"text":118,"@type":114},"The review describes epigenomic alterations including DNA methylation, histone modifications, and non-coding RNA regulation. These mechanisms can influence cellular function and immune response regulation.",{"name":120,"@type":111,"acceptedAnswer":121},"Why are PD-1 and PD-L1 important in this context?",{"text":122,"@type":114},"PD-1 and PD-L1 are biomarkers that regulate immune responses to cancer cells. The review notes that epigenetic modifications may affect their expression, potentially impacting immunotherapy efficacy.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},384289,1790618845,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},24464137899374,"https://us-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Cancer Management and Research Dovepress  \nopen access to scientific and medical research  \n Open Access Full Text Article REVIEW  \nEpigenome-Driven Strategies for Personalized Cancer Immunotherapy  \nGabriel Iudy Yamaguchi Rocha 1 , Jonathas Eduardo Miranda Gomes 1 , Michel Lopes Leite 1 , 2 , Nicolau B da Cunha 1 , 3 ,4 , Fabricio F Costa 1 , 5 , 6  \n1Genomic Sciences and Biotechnology Program, Catholic University of Brasilia, Brasília, DF, Brazil; 2Department of Cell Biology, Institute of Biological Sciences, Campus Darcy Ribeiro, University of Brasilia (UnB), Brasília, DF, Brazil; 3Faculty of Agronomy and Veterinary Medicine (FAV), Campus Darcy Ribeiro, University of Brasilia (UnB), Brasília, DF, Brazil; 4Graduate Program in Agronomy, Campus Darcy Ribeiro, University of Brasilia (UnB), Brasília, DF, Brazil; 5Cancer Biology and Epigenomics Program, Northwestern University’s Feinberg School of Medicine, Chicago, IL, USA; 6Genomic Enterprise, San Francisco CA, USA  \nCorrespondence: Fabricio F Costa, Genomic Sciences and Biotechnology Program, UCB SGAN 916 Modulo B, Bloco C, Brasília, DF, 70790-160, Brazil, Email [fcosta@genomicenterprise.com](fcosta@genomicenterprise.com); Nicolau B da Cunha, Faculty of Agronomy and Veterinary Medicine (FAV), University of Brasília (UnB), Campus Darcy Ribeiro, Brasília, DF, 70910-900, Brazil, Email [nicolau.cunha@unb.br](nicolau.cunha@unb.br)  \n\n| Abstract: Fighting cancer remains one of the greatest challenges for science in the 21st century. Advances in immunotherapy against different types of cancer have greatly contributed to the treatment, remission, and cure of patients. In this context, knowledge of epigenetic phenomena, their relationship with tumor cells and how the immune system can be epigenetically modulated represent some of the greatest advances in the development of anticancer therapies. Epigenetics is a rapidly growing field that studies how environmental factors can affect gene expression without altering DNA sequence. Epigenomic changes include DNA methylation, histone modifications, and non-coding RNA regulation, which impact cellular function. Epigenetics has shown promise in developing cancer therapies, such as immunotherapy, which aims to stimulate the immune system to attack cancer cells. For example, PD-1 and PD-L1 are biomarkers that regulate the immune response to cancer cells and recent studies have shown that epigenetic modifications can affect their expression, potentially influencing the efficacy of immunotherapy. New therapies targeting epigenetic modifications, such as histone deacetylases and DNA methyltransferases, are being developed for cancer treatment, and some have shown promise in preclinical studies and clinical trials. With growing understanding of epigenetic regulation, we can expect more personalized and effective cancer immunotherapies in the future. This review highlights key advances in the use of epigenetic and epigenomic tools and modern immuno-oncology strategies to treat several types of tumors.\u003Cbr>Keywords: epigenetics, epigenomics, PD-1, PD-L1, epigenetic biomarkers, oncology, immunotherapy |\n| --- |\n| Introduction\u003Cbr>Epigenetics is the study of changes in the expression of genes that occur without changes to the underlying DNA sequence.1 These changes can be caused by a variety of factors, including environmental exposures, aging, and disease.2 Oncology is the branch of medicine that deals with the study and treatment of cancer.2 In recent years, there has been increasing interest in the intersection of these two fields, as epigenetic changes have been found to play a role in the development and progression of many types of cancer.3\u003Cbr>One way in which epigenetics contributes to cancer is through changes in the way that genes are expressed. For example, certain genes known as tumor suppressors are responsible for keeping cell growth in check.1 These genes can be turned offor“silenced” through a process known as methylation, which involves t","cbCaicWhDLTqsvZs","https://ap.wps.com/l/cbCaicWhDLTqsvZs","pdf",4209048,17,"English","# Introduction\n## Epigenetics and gene expression changes\n## Epigenetic control of tumor suppressors\n## Chromatin structure and histone modifications\n## Epigenetic links to drug resistance","[{\"question\":\"How does epigenetics influence cancer development?\",\"answer\":\"Epigenetics changes gene expression without altering DNA sequence. It includes processes such as DNA methylation that can silence tumor suppressor genes, enabling uncontrolled cell division.\"},{\"question\":\"What epigenomic mechanisms are discussed in relation to immunotherapy?\",\"answer\":\"The review describes epigenomic alterations including DNA methylation, histone modifications, and non-coding RNA regulation. These mechanisms can influence cellular function and immune response regulation.\"},{\"question\":\"Why are PD-1 and PD-L1 important in this context?\",\"answer\":\"PD-1 and PD-L1 are biomarkers that regulate immune responses to cancer cells. The review notes that epigenetic modifications may affect their expression, potentially impacting immunotherapy efficacy.\"}]","Epigenome-Driven Strategies for Personalized Cancer Immunotherapy - review | PDF",1790262051,43]