[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-373488-105":59,"doc-detail-373488-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","epigenetic-regulators-in-cancer-therapy-and-progression","Epigenetic regulators in cancer therapy and progression","","Epigenetic regulators shape cancer initiation and development by altering gene expression without changing the underlying DNA sequence. Key epigenetic modifications include DNA methylation and histone mark patterns, driven by dysregulated writers, readers, and erasers. The review connects shared epigenetic features across tumor types to phenotypic plasticity, tumor heterogeneity, metastasis, proliferation, and medication resistance. It also summarizes how chromatin remodeling, noncoding RNAs, and extracellular signaling influence both transient and persistent epigenetic states, and highlights therapeutic inhibitor strategies targeting epigenetic enzymes.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/epigenetic-regulators-in-cancer-therapy-and-progression/373488/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/epigenetic-regulators-in-cancer-therapy-and-progression/373488.png","ImageObject",300,407,{"name":92,"@type":93},"Aditya","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are epigenetic modifications and why do they matter in cancer?","Question",{"text":112,"@type":113},"Epigenetic modifications are heritable changes in gene activity that do not alter the DNA sequence. In cancer, they influence gene expression and help drive tumor initiation, progression, and treatment-related traits.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which epigenetic processes are described as main drivers?",{"text":117,"@type":113},"DNA methylation changes and histone mark pattern alterations are presented as the main drivers. These include enzyme-mediated methylation and histone modification events.",{"name":119,"@type":110,"acceptedAnswer":120},"How can targeting epigenetic regulators support cancer therapy?",{"text":121,"@type":113},"The review highlights inhibitors aimed at epigenetic enzymes because epigenetic regulation is intrinsically reversible, unlike irreversible genetic mutations. This makes epigenetic machinery a viable therapeutic intervention point.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},373488,1790324996,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962085564549,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","npj | precision oncology Review  \nPublished in partnership with The Hormel Institute, University of Minnesota  \n[https://doi.org/10.1038/s41698-025-01003-7](https://doi.org/10.1038/s41698-025-01003-7)  \nEpigenetic regulators in cancer therapy and progression  \n Check for updates  \nAt the forefront of  \n\n| Hany E. Marei  |  |\n| --- | --- |\n| Heritable gene activity variations that do not alter the underlying DNA sequence are known as epigenetic modifications. Mutations that disrupt genome structure and function are key drivers of oncogenesis. In addition to genetic mutations that cause direct disruptions in the DNA sequence, epigenetic changes can affect gene expression, which helps the development of cancerous traits. Changes in DNA methylation and histone mark patterns are the main drivers of these epigenetic modifications, as they encourage the growth and spread of tumors. In this review, we explore the substantial implications of epigenetic control on tumor genesis, metastatic behaviour, metabolic pathways, and the tumor microenvironment, delving into the intricacies of this intricate regulation. We pay special attention to the dysregulation at every stage of epigenetic modulation, which includes, but isnot limited to, abnormalities in the enzymes that modify histones and methylate DNA, subunit loss or fusions in chromatin remodeling complexes, and disruptions in higher-order chromatin structure. We also highlight the development of inhibitors of medications targeted at epigenetic enzymes and summarize the abnormal roles of enzymes in DNA methylation, histone acetylation, and histone methylation during tumour progression. |  |\n| The notion that changes in cellular phenotype are passed across generations, regardless ofchanges in DNA sequence, was named epigenetics when it was first described1. Conrad Waddington coined the word “epigenetics” in 1942 to explain the relationship between genotype and phenotype2. Classical genetics has long held that DNA sequences of DNA determine cell phenotypes, a belief that dates back to the discovery of DNA and the double helix structure. In cells, DNA is bundled into chromatin, with nucleosomes serving as the basic repeating unit. An octamer of four core histones (H2A, H2B, H3, and H4) is encircled by a 147 base-pair (bp) length of DNA. The usual description of cancer is that it is a collection of several diseases, each caused by a different mutational mechanism and requiring a different course of treatment. There are similarities in the epigenetic makeup of cancer types, especiallywith relation to tumor heterogeneity and medication resistance, eventhough the cancer types differ in terms ofthe tissue oforigin and related mutation spectrum3. This common epigenetic environment plays a significant role in phenotypic plasticity, which is essential for intricate changes like increased metastasis and cell proliferation4. It has long been known that the diversity and adaptability of cells are essential components driving the development of cancer. Coordinated gene expression programs in these cells often result in complex and diverse behaviors. These programs showa clear divergence from those that defined the initial tissue phenotypes, indicating a more intricate level of cancer biology. Therefore, whereas | genetic changes may predispose cells to novel phenotypic states, they do not solely control the establishment of these states or their development5. The elements involved in different modification patterns can be divided into three roles: “writer,”“reader,” and “eraser.” The “writers” and “erasers” refer to enzymes that transfer or remove chemical groups to or from DNA or histones, respectively.“Readers” are proteins that can recognize the modified DNA or histones. Generally speaking, epigenetic events involve DNA methylation, histone modification, the readout of these modifications, chromatin remodeling, and the effects of noncoding RNA. Highthroughput technologies have significantly improved and expan","cbCaimJFQ2ZeyefM","https://ap.wps.com/l/cbCaimJFQ2ZeyefM","pdf",1845331,18,"English","# Epigenetic modifications and cancer overview\n## DNA methylation and histone mark dysregulation\n## Writers, readers, and erasers\n## Chromatin remodeling, noncoding RNA, and signaling\n## Therapeutic targeting of epigenetic enzymes","[{\"question\":\"What are epigenetic modifications and why do they matter in cancer?\",\"answer\":\"Epigenetic modifications are heritable changes in gene activity that do not alter the DNA sequence. In cancer, they influence gene expression and help drive tumor initiation, progression, and treatment-related traits.\"},{\"question\":\"Which epigenetic processes are described as main drivers?\",\"answer\":\"DNA methylation changes and histone mark pattern alterations are presented as the main drivers. These include enzyme-mediated methylation and histone modification events.\"},{\"question\":\"How can targeting epigenetic regulators support cancer therapy?\",\"answer\":\"The review highlights inhibitors aimed at epigenetic enzymes because epigenetic regulation is intrinsically reversible, unlike irreversible genetic mutations. This makes epigenetic machinery a viable therapeutic intervention point.\"}]","Epigenetic regulators in cancer therapy and progression | PDF",1790199703,45]